Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Shinji Kamada"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Cellular senescence is defined as irreversible growth arrest induced by various stress, such as DNA damage and oxidative stress. Senescent cells exhibit various characteristic morphological changes including enlarged morphology. In our recen
Externí odkaz:
https://doaj.org/article/29318c9ac0144953bd14b72dff83a2a5
Publikováno v:
Biology Open, Vol 3, Iss 6, Pp 542-552 (2014)
The Tsc1–Tsc2 complex homologous to human tuberous sclerosis complex proteins governs amino acid uptake by regulating the expression and intracellular distribution of amino acid transporters in Schizosaccharomyces pombe. Here, we performed a geneti
Externí odkaz:
https://doaj.org/article/25d65b306dcc47bcbf7f1231c3b2dc30
Autor:
Masayuki Nakano, Akio Nakashima, Taiki Nagano, Shintaro Ishikawa, Ushio Kikkawa, Shinji Kamada
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80411 (2013)
Branched-chain amino acids (BCAAs) have been applied as an oral supplementation to patients with liver cirrhosis. BCAAs not only improve nutritional status of patients but also decrease the incidence of liver cancer. Mammalian target of rapamycin (mT
Externí odkaz:
https://doaj.org/article/e42ff7eee4094d95bab0ee587934ecc2
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18449 (2011)
Caspases have been suggested to contribute to not only apoptosis regulation but also non-apoptotic cellular phenomena. Recently, we have reported the involvement of caspase-7 to the cell cycle progression at mitotic phase by knockdown of caspase-7 us
Externí odkaz:
https://doaj.org/article/c72b71b4789642a89ae725b79085a757
Autor:
Shinji Kamada1, Yoshiki Nakajima2 yoshi-n@okayama-u.ac.jp, Jian-Ren Shen2 shen@cc.okayama-u.ac.jp
Publikováno v:
Journal of Biological Chemistry. Jul2023, Vol. 299 Issue 7, p1-11. 11p.
Autor:
Taiki Nagano, Shinji Kamada, Tetsushi Iwasaki, Shione Kuwaba, Kentaro Mio, Taiichi Osumi, Yuto Awai
Publikováno v:
Molecular Biology of the Cell
Cellular senescence is a state of permanent proliferative arrest induced by a variety of stresses, such as DNA damage. The transcriptional activity of p53 has been known to be essential for senescence induction. It remains unknown, however, whether a
Autor:
Yuto Awai, Akio Nakashima, Shinji Kamada, Anju Terachi, Shione Kuwaba, Kengo Onishi, Shota Asano, Kiyoko Nagai, Tetsushi Iwasaki, Ushio Kikkawa, Ryoko Katasho, Taiki Nagano
Publikováno v:
The Journal of Biological Chemistry
Although senescent cells display various morphological changes including vacuole formation, it is still unclear how these processes are regulated. We have recently identified the gene, lymphocyte antigen 6 complex, locus D (LY6D), to be upregulated s
Autor:
Kosuke Kawai, Shinji Kamada, Mizuki Kinugasa, Akio Nakashima, Tetsushi Iwasaki, Yuto Awai, Ushio Kikkawa, Taiki Nagano, Kengo Onishi
Publikováno v:
Journal of Cell Science.
Cellular senescence is a complex stress response characterized by permanent loss of proliferative capacity and is implicated in age-related disorders. Although the transcriptional activity of p53 (encoded by TP53) is known to be vital for senescence
Publikováno v:
The International journal of developmental biology. 60(7-8-9)
Differentiated somatic cells and nuclei can be reprogrammed to a pluripotent undifferentiated state in the cytoplasm of oocytes and eggs. The ability of the gamete cells to induce reprogramming is not species-specific, so the extracts prepared from t
Autor:
Anju Terachi, Shinji Kamada, Akio Nakashima, Tetsushi Iwasaki, Shunsuke Yamao, Ryoko Katasho, Ushio Kikkawa, Kosuke Kawai, Haruki Itoh, Hidetora Yarimizu, Taiki Nagano
Publikováno v:
Life Science Alliance
This study reveals a novel role of d-amino acid oxidase in promoting cellular senescence induced by genotoxic stresses via enzymatic generation of reactive oxygen species.
d-amino acid oxidase (DAO) is a flavin adenine dinucleotide (FAD)–depen
d-amino acid oxidase (DAO) is a flavin adenine dinucleotide (FAD)–depen