Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shinji Kagimoto"'
Autor:
Sachiko Honjo, Kinsuke Tsuda, Hiroyuki Koshiyama, Kyoko Hara, Yoshio Nakamura, S. Fujimoto, Tatsuro Ishida, Shinji Kagimoto, Ataru Taniguchi, Koichiro Nabe, Akira Fukuda, Taizo Yamamoto, Noriaki Kume, Yoshiyuki Hamamoto, Yoshio Fujioka, Akane Iwakura, Akira Kuroe, Hiroki Ikeda, Kiyoshi Tanaka, Michihiro Ohya, Ken-ichi Hirata
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 18:8-15
Aim: Pitavastatin significantly improved lipid profiles and reduced serum high-sensitivity C-reactive protein (hs-CRP) levels in a multi-center and prospective study. The aim of this study was to explore the effect of pitavastatin on serum levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d5df926c1e56308bbe5f62ae6c2300
https://doi.org/10.5551/jat.5942
https://doi.org/10.5551/jat.5942
Autor:
Yutaka Seino, Akari Inada, Shimpei Fujimoto, Yuichiro Yamada, Shinji Kagimoto, Toshio Iwakura, Akira Kubota, Yu Ihara, Yoshimichi Someya
Publikováno v:
Biochemical and Biophysical Research Communications. 271:422-428
Cytosolic Ca(2+) elevations are known to be involved in triggering apoptosis in many tissues, but the effect of sustained enhancement of Ca(2+) influx on apoptosis in beta cells remains unknown. We have found that the viability of RINm5F cells is dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee719b6dd2f64fed678e81da452f6d7
https://doi.org/10.1006/bbrc.2000.2616
https://doi.org/10.1006/bbrc.2000.2616
Autor:
Yuichiro Yamada, Tetsuya Adachi, Yutaka Seino, Rie Watanabe, Yasuhiro Sunaga, Toshio Iwakura, Nobuhiro Ban, Yoshimichi Someya, Akira Kuroe, Yu Ihara, Zhen-Ping Shen, Akira Kubota, Shinji Kagimoto, Kinsuke Tsuda, Kazumasa Miyawaki, Akari Inada
Publikováno v:
Biochemical and Biophysical Research Communications. 254:707-712
The biological responses of the transforming growth factor beta (TGF-beta) superfamily are induced by activation of a receptor complex and Smad proteins. We surveyed the TGF-beta superfamily receptors using the degenerate PCR strategy, and found acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455a5fe794cac082da7ffcf3614a7b15
https://doi.org/10.1006/bbrc.1998.0118
https://doi.org/10.1006/bbrc.1998.0118
Autor:
Tomohiko Taminato, Akira Kubota, Yuichiro Yamada, Kinsuke Tsuda, Yutaka Seino, Koichiro Yasuda, Shinji Kagimoto, Tadao Hayami, Yoshimichi Someya, Rie Watanabe, Yu Ihara
Publikováno v:
Diabetes. 45:1701-1705
Gastric inhibitory polypeptide (GIP) potently stimulates insulin secretion from pancreatic islets in the presence of glucose as an incretin. Because the insulinotropic effect of GIP is reduced in NIDDM, it should be clarified whether defects in the G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724d0830c38ffd4dbf94683434d86949
https://doi.org/10.2337/diabetes.45.12.1701
https://doi.org/10.2337/diabetes.45.12.1701
Autor:
Yutaka Seino, Yasuhiro Yamada, Yoshimasa Okamoto, T. Kozasa, Yoshimichi Someya, Yu Ihara, Susumu Seino, Akira Kubota, Kunio Yasuda, Shinji Kagimoto
Publikováno v:
Biochemical and Biophysical Research Communications. 204:176-186
The signal transduction pathways of a cloned human somatostatin receptor subtype, SSTR1, have been investigated in CHO cells stably expressing this receptor. In SSTR1-expressing CHO cells, somatostatin-14 inhibits forskolin-stimulated cAMP formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58109c7e5c0de965ffc76843d50114d
https://doi.org/10.1006/bbrc.1994.2442
https://doi.org/10.1006/bbrc.1994.2442
Autor:
Yutaka Seino, Akira Kubota, Susumu Seino, Tsuda K, Hiroo Imura, Yoshiji Yamada, Akira Shimatsu, M Imamura, Shinji Kagimoto
Publikováno v:
Journal of Clinical Investigation. 93:1321-1325
The presence of somatostatin receptors has been demonstrated in various endocrine tumors as well as in normal tissues. We recently have cloned five human somatostatin receptor subtypes (SSTR1-SSTR5). These mRNAs are expressed in a tissue-specific man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c704f0272376ef8cd2e5ce1e60fdf1
https://doi.org/10.1172/jci117090
https://doi.org/10.1172/jci117090
Autor:
Kazuhiro Masuda, Susumu Seino, Yutaka Seino, Kunio Yasuda, Akira Kubota, Yu Ihara, Qing Li, Hiroo Imura, Y. Yamada, Yoshimichi Someya, Shinji Kagimoto
Publikováno v:
Biochemical and Biophysical Research Communications. 195:844-852
Somatostatin exerts diverse effects in various tissues upon binding its specific membrane receptors. Recently, we have cloned three different somatostatin receptor subtypes. Here we report the sequence and functional expression of a fourth and a fift
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4423fe2628018c659bcae5e028838f8a
https://doi.org/10.1006/bbrc.1993.2122
https://doi.org/10.1006/bbrc.1993.2122
Autor:
Susumu Seino, T. Reisine, Yutaka Seino, M. Seino, Akira Kubota, Shinji Kagimoto, S. F. Law, Graeme I. Bell, Y. Yamada, Yu Ihara
Publikováno v:
Molecular Endocrinology. 6:2136-2142
We previously reported the cloning of two distinct somatostatin receptor (SSTR) subtypes, SSTR1 and SSTR2. Although both SSTR1 and SSTR2 bound somatostatin specifically and with high affinity, neither was coupled to adenylyl cyclase, a major cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752289f8ce7b8412abfb63afb431354b
https://doi.org/10.1210/mend.6.12.1337145
https://doi.org/10.1210/mend.6.12.1337145
Autor:
Kinsuke Tsuda, Yu Ihara, Shinji Kagimoto, Yoshimichi Someya, Akira Kubota, Yutaka Seino, Yuichiro Yamada, Akari Inada, Akira Kuroe, Koichiro Yasuda
Publikováno v:
Biochemical and biophysical research communications. 253(3)
To further clarify the mechanism of impaired insulin gene transcription in the diabetic state, we investigated the expression and function of the transcriptional repressor CREM (CRE modulator) in rat pancreatic islets. The CREM gene generates both tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11685aaa645a4c5b9d58cc0753d7666
https://pubmed.ncbi.nlm.nih.gov/9918792
https://pubmed.ncbi.nlm.nih.gov/9918792
Autor:
Yuichiro Yamada, Rie Watanabe, Shinji Kagimoto, Yoshimichi Someya, Koichiro Yasuda, Yu Ihara, Akira Kuroe, Hitoshi Ishida, Akira Kubota, Yutaka Seino
Publikováno v:
Biochemical and biophysical research communications. 235(1)
The signal transduction pathways of a cloned human gastric inhibitory polypeptide (GIP) receptor have been investigated in CHO cells stably expressing this receptor. Exposure of GIP receptor expressing cells to GIP significantly increased MAP kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c6a4c84c07131c02af65b56cf9efb5
https://pubmed.ncbi.nlm.nih.gov/9196057
https://pubmed.ncbi.nlm.nih.gov/9196057