Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Shinji Go"'
Autor:
Jin-ichi Inokuchi, Shinji Go, Akemi Suzuki, Osamu Nakagawasai, Takayo Odaira-Satoh, Lucas Veillon, Takahiro Nitta, Paul McJarrow, Hirotaka Kanoh, Kei-ichiro Inamori, Koichi Tan-No, Michael Collett
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GM3SD) causes an absence of GM3 and all downstream biosynthetic derivatives, including all the a-, b-, c-series gangliosides, commonly fou
Externí odkaz:
https://doaj.org/article/caa20b818c9a4c83b5ef00dcc0053041
Autor:
Takashi Watanabe, Akemi Suzuki, Shin Ohira, Shinji Go, Yuta Ishizuka, Takuya Moriya, Yoshiyuki Miyaji, Tota Nakatsuka, Keita Hirata, Atsushi Nagai, Junko Matsuda
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 12, Pp 100303- (2022)
Glycosphingolipids (GSLs) are composed of a polar glycan chain and a hydrophobic tail known as ceramide. Together with variation in the glycan chain, ceramides exhibit tissue-specific structural variation in the long-chain base (LCB) and N-acyl chain
Externí odkaz:
https://doaj.org/article/147c5259c428431f998dd5ba707b2309
Autor:
Naoko Inamura, Momoko Kito, Shinji Go, Soichiro Kishi, Masanori Hosokawa, Kiyofumi Asai, Nobuyuki Takakura, Hirohide Takebayashi, Junko Matsuda, Yasushi Enokido
Publikováno v:
Neurobiology of Disease, Vol 120, Iss , Pp 51-62 (2018)
Krabbe disease (KD), or globoid cell leukodystrophy, is an inherited lysosomal storage disease with leukodystrophy caused by a mutation in the galactosylceramidase (GALC) gene. The majority of patients show the early onset form of KD dominated by cer
Externí odkaz:
https://doaj.org/article/d5dde1e035be4af9829f6c011d3604e3
Autor:
Lucas Veillon, Shinji Go, Wakana Matsuyama, Akemi Suzuki, Mika Nagasaki, Yutaka Yatomi, Jin-Ichi Inokuchi
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129645 (2015)
Serum GM3 molecular species were quantified in 125 Japanese residents using tandem mass spectrometry multiple reaction monitoring. Individuals were categorized by the presence or absence of metabolic disease risk factors including visceral fat accumu
Externí odkaz:
https://doaj.org/article/450500bd740342e9ab8b91fc0374c43e
Publikováno v:
Glycoconjugate Journal. 39:619-631
A transition of sialic acid (Sia) species on GM3 ganglioside from N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic acid (Neu5Gc) takes place in mouse C2C12 myoblast cells during their differentiation into myotube cells. However, the meaning o
Publikováno v:
Advances in Neurobiology ISBN: 9783031123894
Advances in Neurobiology ISBN: 9781493911530
Advances in Neurobiology ISBN: 9781493911530
Glycoproteins carrying O-linked N-acetylgalactosamine, N-acetylgluco-samine, mannose, fucose, glucose, and xylose are found in the nervous system. Lipids can be glycosylated as well. Membrane lipid, ceramide, is modified by the addition of either glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5445cf65a84b579501d03865ee30d258
https://doi.org/10.1007/978-3-031-12390-0_4
https://doi.org/10.1007/978-3-031-12390-0_4
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Replication stress is a major contributor to tumorigenesis because it provides a source of chromosomal rearrangements via recombination events. PARK2, which encodes parkin, a regulator of mitochondrial homeostasis, is located on one of the c
Externí odkaz:
https://doaj.org/article/5f37204c6fe149ec973d154bf659e491
Autor:
Yasuo Okamoto, Tatsuya Tai, Yasuhiro Takenouchi, Hitoshi Houchi, Keisuke Kitakaze, Junko Matsuda, Kazuhito Tsuboi, Akira Tokumura, Takashi Watanabe, Tamotsu Tanaka, Hanif Ali, Natsuo Ueda, Yoko Okamoto, Ryouhei Yamashita, Iffat Ara Sonia Rahman, Shinji Go, Toru Uyama
Publikováno v:
The FASEB Journal. 35
Autor:
Akira Abe, Miki Hiraoka, Shinji Go, Masaki Murata, Hiroshi Ohguro, Jin-ichi Inokuchi, Ei Ohkawa
Publikováno v:
Current Eye Research. 44:664-670
Purpose: Most complex gangliosides in vertebrates are formed from ganglioside GM3. GM3 deficiency in humans can result in epilepsy and visual impairment. To investigate whether a deficiency of GM3 is involved in visual function, ST3GAL5-/- mice with
Autor:
Shinji Go, Takashi Watanabe, Atsuo Nakayama, Junko Matsuda, Yasushi Enokido, Hiroshi Takase, Hirohide Takebayashi, Nobuyuki Takakura, Naoko Inamura
Publikováno v:
Brain Pathology
Krabbe disease (KD), also known as globoid cell leukodystrophy, is an inherited demyelinating disease caused by the deficiency of lysosomal galactosylceramidase (GALC) activity. Most of the patients are characterized by early‐onset cerebral demyeli