Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Shinji, Kobuchi"'
Publikováno v:
Anticancer Research. 43:1121-1130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09820190f7bac8ffe4dac441467f64ed
https://doi.org/10.21873/anticanres.16257
https://doi.org/10.21873/anticanres.16257
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 203 (2022)
This study was conducted to evaluate the long-term plasma concentration profiles of dapagliflozin and its effects on the glycated hemoglobin (HbA1c) level, body weight, and estimated glomerular filtration rate (eGFR) in 72 Japanese outpatients with t
Externí odkaz:
https://doaj.org/article/ee53ec6d8c4d4daf96507c309f1d0539
Publikováno v:
Xenobiotica. 52:697-706
Myelosuppression is a dose-limiting toxicity of uracil-tegafur (UFT), which contains uracil and the 5‑fluorouracil prodrug tegafur, and inhibits the continuation of chemotherapy, causing treatment failure. A proper dosing strategy to avoid severe m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e69822fc7f2474841d1effbf198f09a
https://doi.org/10.1080/00498254.2022.2142696
https://doi.org/10.1080/00498254.2022.2142696
Autor:
Shinji Kobuchi, Naoya Kanda, Taichi Okumi, Yuma Kano, Himawari Tachi, Yukako Ito, Toshiyuki Sakaeda
Publikováno v:
Xenobiotica. 52:583-590
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::128a45f438cf15e0c2e24d88a04b4b6f
https://doi.org/10.1080/00498254.2022.2098201
https://doi.org/10.1080/00498254.2022.2098201
Publikováno v:
Journal of Pharmaceutical Sciences. 111:1522-1530
Capecitabine and irinotecan (CPT-11) combination regimen (XELIRI) is used for colorectal cancer treatment. Capecitabine is metabolized to 5-fluorouracil (5-FU) by three enzymes, including carboxylesterase (CES). CES can also convert CPT-11 to 7-ethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9d9661e2e6f6c7486d037808068958
https://doi.org/10.1016/j.xphs.2021.12.021
https://doi.org/10.1016/j.xphs.2021.12.021
Publikováno v:
Antibiotics, Vol 9, Iss 4, p 199 (2020)
Recent research has found higher levels and longer total exposure of azithromycin, a macrolide antibiotic agent, in the interstitial fluid of the skin than in the plasma. This unique distribution is expected to contribute to its antimicrobial activit
Externí odkaz:
https://doaj.org/article/8216a7bc1e354a78a3583f0cb2d15f00
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 125 (2020)
Oxaliplatin (L-OHP) is widely prescribed for treating gastroenterological cancer. L-OHP-induced peripheral neuropathy is a critical toxic effect that limits the dosage of L-OHP. An ideal chemotherapeutic strategy that does not result in severe periph
Externí odkaz:
https://doaj.org/article/2a3c6e6d51734a7ea9992e7d5bd67bb3
Autor:
Yukako Ito, Shinji Kobuchi, Kenji Sasaki, Yusuke Kita, Yukiko Hiramatsu, Tomoya Uno, Toshiyuki Sakaeda
Publikováno v:
Journal of Pharmaceutical Sciences. 110:898-904
The pathogenic bacterium Staphylococcus aureus can penetrate host cells. However, intracellular S. aureus is not considered during antimicrobial agent selection in clinical chemotherapy because of the lack of information about drug transportability i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c7733b0e21c399668bf437361219cc
https://doi.org/10.1016/j.xphs.2020.09.045
https://doi.org/10.1016/j.xphs.2020.09.045
Autor:
Yuzuru Ikehara, Mayumi Yoshimura, Yuki Matsui, Susumu Nakata, Yukako Ito, Kikuko Amagase, Hayao Nakanishi, Shinji Kobuchi, Chiami Moyama, Eriko Inoue
Publikováno v:
Anticancer Research. 40:6781-6789
Background/aim To examine the dynamics of circulating tumour cells (CTCs) in pancreatic cancer (PC), new mouse CTC models from human PC xenografts were developed. Materials and methods Orthotopic (pancreas) and heterotopic (subcutaneous) transplantat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff5daa42d7c2584b94333ce223bbf5aa
https://doi.org/10.21873/anticanres.14701
https://doi.org/10.21873/anticanres.14701
Autor:
Kimie Imai, Shun-ichi Isa, Shuhei Marutani, Toshiyuki Sakaeda, Shinji Atagi, Keiko Nakao, Kyoichi Okishio, Ayano Iwazaki, Akihiro Tamiya, Motohiro Tamiya, Masaki Kanazu, Shinji Kobuchi, Tomonori Hirashima
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
To investigate the exposure–safety relationships of afatinib in Japanese population, we performed population pharmacokinetics (PK) analysis of afatinib in Japanese advanced non-small cell lung cancer patients harboring epidermal growth factor recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a593668f42a3bf734d02f3a97985399
http://link.springer.com/article/10.1038/s41598-019-54804-9
http://link.springer.com/article/10.1038/s41598-019-54804-9