Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Shinichiro Chuma"'
Autor:
Yuki Tanaka, Shin Kadota, Jian Zhao, Hideki Kobayashi, Satomi Okano, Masaki Izumi, Yusuke Honda, Hajime Ichimura, Naoko Shiba, Takeshi Uemura, Yuko Wada, Shinichiro Chuma, Tsutomu Nakada, Shugo Tohyama, Keiichi Fukuda, Mitsuhiko Yamada, Tatsuichiro Seto, Koichiro Kuwahara, Yuji Shiba
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) can be used to treat heart diseases; however, the optimal maturity of hiPSC-CMs for effective regenerative medicine remains unclear. We aimed to investigate th
Externí odkaz:
https://doaj.org/article/b753b6a2aa8c41179aa9cf4247289cee
Autor:
Naoko Shiba, Xiao Yang, Mitsuto Sato, Shin Kadota, Yota Suzuki, Masahiro Agata, Kohei Nagamine, Masaki Izumi, Yusuke Honda, Tomoya Koganehira, Hideki Kobayashi, Hajime Ichimura, Shinichiro Chuma, Junichi Nakai, Shugo Tohyama, Keiichi Fukuda, Daigo Miyazaki, Akinori Nakamura, Yuji Shiba
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102060- (2023)
Exon-skipping therapy is a promising treatment strategy for Duchenne muscular dystrophy (DMD), which is caused by loss-of-function mutations in the DMD gene encoding dystrophin, leading to progressive cardiomyopathy. In-frame deletion of exons 3–9
Externí odkaz:
https://doaj.org/article/feccee7ab1c242b9ad7ff132d76464c6
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Germline mutations underlie genetic diversity and species evolution. Previous studies have assessed the theoretical mutation rates and spectra in germ cells mostly by analyzing genetic markers and reporter genes in populations and pedigrees.
Externí odkaz:
https://doaj.org/article/b8dd418157e94e4c8b68cf453b792d45
Autor:
Kaori Yamauchi, Tatsuhiko Ikeda, Mihoko Hosokawa, Norio Nakatsuji, Eihachiro Kawase, Shinichiro Chuma, Kouichi Hasegawa, Hirofumi Suemori
Publikováno v:
Stem Cell Reports, Vol 14, Iss 3, Pp 506-519 (2020)
Summary: Naive and primed human pluripotent stem cells (hPSCs) have provided useful insights into the regulation of pluripotency. However, the molecular mechanisms regulating naive conversion remain elusive. Here, we report intermediate naive convers
Externí odkaz:
https://doaj.org/article/b3ec6887c22c452ca2844c839ea309ed
Autor:
Deepti Anand, Salma Al Saai, Sanjaya K. Shrestha, Carrie E. Barnum, Shinichiro Chuma, Salil A. Lachke
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mutations/deficiency of TDRD7, encoding a tudor domain protein involved in post-transcriptional gene expression control, causes early onset cataract in humans. While Tdrd7 is implicated in the control of key lens mRNAs, the impact of Tdrd7 deficiency
Externí odkaz:
https://doaj.org/article/28f9b12381de467dbd8330fd7a924be1
Autor:
Shinichiro Chuma, Ramesh S Pillai
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000770 (2009)
Externí odkaz:
https://doaj.org/article/b6f3fdf44184488caae7d57a6bfc19e3
Autor:
Hiroko Morimoto, Mito Kanatsu-Shinohara, Seiji Takashima, Shinichiro Chuma, Norio Nakatsuji, Masanori Takehashi, Takashi Shinohara
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7909 (2009)
BACKGROUND:Spermatogonial stem cells (SSCs) continuously undergo self-renewal division to support spermatogenesis. SSCs are thought to have a fixed phenotype, and development of a germ cell transplantation technique facilitated their characterization
Externí odkaz:
https://doaj.org/article/ccd5b97fa6e34a6e99bd3802ff0724c9
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5338 (2009)
BACKGROUND: Mouse embryonic stem (ES) cells can differentiate into female and male germ cells in vitro. Primate ES cells can also differentiate into immature germ cells in vitro. However, little is known about the differentiation markers and culture
Externí odkaz:
https://doaj.org/article/45dcdb6618ad45c8bbcf20f286313113
Autor:
Toru Nishimura, Tatsuhiko Arakawa, Toru Nakano, Satomi Kuramochi-Miyagawa, Taro Tachibana, Masahito Ikawa, Hidetoshi Hasuwa, Ippei Nagamori, Yusuke Shiromoto, Shinichiro Chuma
Publikováno v:
Biology of Reproduction. 101:248-256
PIWI-interacting RNAs (piRNAs), a subclass of germ cell-specific noncoding small RNAs, are essential for de novo DNA methylation of retrotransposon genes in embryonic testes. PIWIL2/MILI, one of three mouse PIWI family members, is indispensable for p
Autor:
Deepti Anand, Salma Al Saai, Sanjaya K. Shrestha, Carrie E. Barnum, Shinichiro Chuma, Salil A. Lachke
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mutations/deficiency of TDRD7, encoding a tudor domain protein involved in post-transcriptional gene expression control, causes early onset cataract in humans. While Tdrd7 is implicated in the control of key lens mRNAs, the impact of Tdrd7 deficiency