Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shinichi Katakura"'
Autor:
Nobutaka Fujii, Atsuko Inouye, T. Segawa, Shinichi Katakura, Yoshio Hayashi, Haruaki Yajima, Kenichi Akaji
Publikováno v:
International Journal of Peptide and Protein Research. 26:121-129
A decapeptide corresponding to the entire amino acid sequence of neurokinin A, a porcine spinal cord peptide, was synthesized in a conventional manner using protecting groups removable by 1 M TFMSA-thioanisole in TFA. The HS-CH2CH2CO group was introd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd2c7aed065a9f872a46ff323b1a6da
https://doi.org/10.1111/j.1399-3011.1985.tb03189.x
https://doi.org/10.1111/j.1399-3011.1985.tb03189.x
Autor:
Ken Osanai, Minoru Iino, Hideyuki Kanno, Yoshifumi Watanabe, Shinichi Katakura, Taketoshi Furugohri, Tatsuya Nishi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1487-1490
A series of 2-(biphenylmethyl)glutaric acid amide derivatives were synthesized and evaluated for NEP inhibitory activity. The mode of inhibitor-enzyme interactions of the most potent compound 3a, with a thiazolylacetic acid group at the P2' position,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6064437e4f45b9957b60d6edba572e91
https://doi.org/10.1016/s0960-894x(96)00255-7
https://doi.org/10.1016/s0960-894x(96)00255-7
Publikováno v:
European Journal of Medicinal Chemistry. 30:387-394
Summary Molecular modeling of a complex between factor Xa (FXa) and DX-9065a, a novel FXa inhibitor, has demonstrated a salt-bridge interaction of the amidinonaphthalene moiety of the inhibitor to the S1 site pocket of the enzyme and a crucial carbox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ad0362a7376e9a4d576e4c5ec55d2d
https://doi.org/10.1016/0223-5234(96)88248-1
https://doi.org/10.1016/0223-5234(96)88248-1
Autor:
Takayasu Nagahara, K. Yamada, Makoto Tanaka, Shinichi Katakura, Hideyuki Kanno, Masayuki Kitagawa, Kenjiro Yamamoto
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f6c821341e7cd298198f960ac3b8b90
https://doi.org/10.1002/chin.199219193
https://doi.org/10.1002/chin.199219193
Autor:
Kazue Inamura, Masahiro Iwamoto, Satoshi Komoriya, Hitoshi Yamaguchi, Yukio Yokoyama, Tsuyoshi Hara, Takayasu Nagahara, Shinichi Katakura
Publikováno v:
ChemInform. 25
Since activated factor X (FXa) is a coagulant enzyme that generates thrombin and participates in both intrinsic and extrinsic coagulation pathways, inhibition of FXa may be more effective than inactivation of thrombin for interrupting blood coagulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f1642398501f7c1d20dad4f818b8144
https://doi.org/10.1002/chin.199433154
https://doi.org/10.1002/chin.199433154
Autor:
T. Furugohri, Ken Osanai, Kannoh. Kannoh., T. Nishi, Shinichi Katakura, M. Iino, Yoshifumi Watanabe
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::682f096ba525bb29cd6238a074eecbc5
https://doi.org/10.1002/chin.199647282
https://doi.org/10.1002/chin.199647282
Autor:
Junko Yasuda, Isao Yasumatsu, Tetsunori Fujisawa, Yasuo Morita, Shinichi Katakura, Tadanori Morikawa, Shinjiro Odake
Publikováno v:
ChemInform. 33
A series of carboxylate compounds were prepared from N(alpha)-substituted 2,3-diaminopropionic acid and were tested for efficacy as matrix metalloproteinase (MMP) inhibitors. During modeling of the initial compound 10a, we utilized three-dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e6dd3289ef432e633e28cc5de2c5ce1
https://doi.org/10.1002/chin.200212229
https://doi.org/10.1002/chin.200212229
Autor:
Takayasu Nagahara, Tsuyoshi Hara, Satoshi Komoriya, Naoaki Kanaya, Shinichi Katakura, Asako Yokoyama, Yukio Yokoyama, Kazue Inamura
Publikováno v:
Bioorganicmedicinal chemistry. 12(9)
Since factor Xa (fXa) plays a pivotal role in the blood coagulation cascade, inhibition of fXa is thought to be an effective treatment for a variety of thrombotic events. (2S)-2-[4-[[(3S)-1-Acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2-naphth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec041b322cd714e844e7c37d52405a7
https://pubmed.ncbi.nlm.nih.gov/15080912
https://pubmed.ncbi.nlm.nih.gov/15080912
Autor:
Shinjiro Odake, Yasuo Morita, Shinichi Katakura, Isao Yasumatsu, Tetsunori Fujisawa, Tadanori Morikawa, Junko Yasuda
Publikováno v:
Chemicalpharmaceutical bulletin. 49(10)
A series of carboxylate compounds were prepared from N(alpha)-substituted 2,3-diaminopropionic acid and were tested for efficacy as matrix metalloproteinase (MMP) inhibitors. During modeling of the initial compound 10a, we utilized three-dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9acdd9a3f5b2926a24c88bf0afcd2a
https://pubmed.ncbi.nlm.nih.gov/11605653
https://pubmed.ncbi.nlm.nih.gov/11605653
Autor:
Irwin D. Kuntz, Connie M. Oshiro, Robert J. Fletterick, Solomon Mpoke, A. Geoffrey SkillmanJr., Ronald M. A. Knegtel, Ching C. Wang, Shinichi Katakura, John R. Somoza, Narsimha R. Munagala
Publikováno v:
Molecular Modeling and Prediction of Bioactivity ISBN: 9781461368571
Most protozoan parasites, such as Leishmania, Plasmodium, Toxoplasma and Trypanosoma, rely on a salvage pathway for their supply of purine ribonucleotides (Wang, 1984). Inhibition of this pathway therefore presents an interesting approach in the figh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71ca296113e4619b0ae3f7dae4560421
https://doi.org/10.1007/978-1-4615-4141-7_86
https://doi.org/10.1007/978-1-4615-4141-7_86
