Zobrazeno 1 - 10 of 89 pro vyhledávání: '"Shingo Yasuhara"'
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Akademický článek
Mito-kaede photoactivation and chase experiment for mitophagy: optimizing flux measurement via fluid exchange system
Autor: Hiroyuki Morinaga, Yoh Sugawara, Yoshinori Kitagawa, Jingyuan Chen, Nobuo Yasuda, Hiroki Ogata, Yoshihiro Yamaguchi, Masao Kaneki, Joseph A Jeevendra Martyn, Shingo Yasuhara
Publikováno v: BioTechniques, Vol 76, Iss 8, Pp 381-393 (2024)
Modulating autophagy and mitophagy, vital cellular quality control systems, offer therapeutic potential for critical illnesses. However, limited drug screening options hinder progress. We present a novel assay using the photoswitchable fluorescent re
Externí odkaz: https://doaj.org/article/e48551f8028541e2abe5ad1fc1c534fd
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2
Akademický článek
Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation
Autor: Harumasa Nakazawa, Kazuhiro Ikeda, Shohei Shinozaki, Masayuki Kobayashi, Yuichi Ikegami, Ming Fu, Tomoyuki Nakamura, Shingo Yasuhara, Yong-Ming Yu, J. A. Jeevendra Martyn, Ronald G. Tompkins, Kentaro Shimokado, Tomoko Yorozu, Hideki Ito, Satoshi Inoue, Masao Kaneki
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Metabolic derangements are a clinically significant complication of major trauma (e.g., burn injury) and include various aspects of metabolism, such as insulin resistance, muscle wasting, mitochondrial dysfunction and hyperlactatemia. Noneth
Externí odkaz: https://doaj.org/article/afe79a61568341ec8376c8fb9c5a6d31
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3
Akademický článek
iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53.
Autor: Harumasa Nakazawa, Kyungho Chang, Shohei Shinozaki, Takashi Yasukawa, Kazuhiro Ishimaru, Shingo Yasuhara, Yong-Ming Yu, J A Jeevendra Martyn, Ronald G Tompkins, Kentaro Shimokado, Masao Kaneki
Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170391 (2017)
Inflammation and apoptosis develop in skeletal muscle after major trauma, including burn injury, and play a pivotal role in insulin resistance and muscle wasting. We and others have shown that inducible nitric oxide synthase (iNOS), a major mediator
Externí odkaz: https://doaj.org/article/14c5f0c8233b4e7d8f0091f301afeab0
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6
104 Parkin-independent Pathway of Mitophagy as a Potential Target Mitochondrial Dysfunctions in Burns
Autor: Jingyuan Chen, Yoh Sugawara, Hiroyuki Morinaga, Jeevendra Martyn, Shingo Yasuhara
Publikováno v: Journal of Burn Care & Research. 43:S68-S69
Introduction In many critical illnesses including burn injury (BI), muscle wasting (MW) with mitochondrial dysfunction (MD) leads to poor prognosis. Disturbed mitochondria can normally be turned over by autophagic degradation of mitochondria (mitopha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da64199c26a8a0cb60365d756ac21c6f
https://doi.org/10.1093/jbcr/irac012.107
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7
Burn-Induced Microglia Activation is Associated With Motor Neuron Degeneration and Muscle Wasting in Mice
Autor: J. A. Jeevendra Martyn, Li Ma, Yinhui Zhou, Shingo Yasuhara, Mohammed A. S. Khan
Publikováno v: Shock. 51:569-579
Burn injury (BI) leads to both systemic and neuro-inflammation and is associated with muscle wasting and weakness, which increase morbidity and mortality. Disuse atrophy is concomitantly present in BI patients. Most studies have focused on muscle wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99beb04f14e797776512b7047f4ff73f
https://doi.org/10.1097/shk.0000000000001300
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8
Myostatin deficiency not only prevents muscle wasting but also improves survival in septic mice
Autor: Shingo Yasuhara, Shohei Shinozaki, Shingo Kasamatsu, Masao Kaneki, Masayuki Kobayashi
Publikováno v: Am J Physiol Endocrinol Metab
Sepsis remains a leading cause of mortality in critically ill patients. Muscle wasting is a major complication of sepsis and negatively affects clinical outcomes. Despite intense investigation for many years, the molecular mechanisms underlying sepsi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fb5369966b8fbb8875fa4c02b638fb
https://europepmc.org/articles/PMC8194407/
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9
Microtubule Defect Involved in ‘Mitophagy Resistance’ Under Subacute Oxidative Stress - Potential Mechanism for Cellular Inflammation
Autor: Shingo Yasuhara, N Yasuda, Aki Kashiwagi, T Shakuo, J. A. Jeevendra Martyn, Takahiko Tamura, Masataka Yokoyama
IntroductionOxidative stress is considered an essential mechanism in ICU-acquired weakness. The roles of oxidative stress in autophagy/mitophagy dysfunction remains elusive. Microtubule serves as an essential guide rail for auto/mitophagosome traffic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a87b9f6689a49a69790cbdf4363728
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10
99 Feasibility of Deep Learning-based Automatic Myofiber Size Measurement for Burn-induced Muscle Wasting and Its Reversal
Autor: Hiroyuki Morinaga, Yoh Sugawara, Jingyuan Chen, Jeevendra Martyn, Shingo Yasuhara
Publikováno v: Journal of Burn Care & Research. 43:S66-S66
Introduction Patients with major burn injury (BI) often develop muscle wasting (MW) and mitochondrial dysfunctions (MD), which affect their prognosis. We have recently shown that auto/mitophagy response is defective in BI model and can be mitigate by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cc04c89a8dc3512467f2d87c1c0f0dd
https://doi.org/10.1093/jbcr/irac012.102
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