Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Shingo Soya"'
Autor:
Khaled Ghandour, Noriaki Ohkawa, Chi Chung Alan Fung, Hirotaka Asai, Yoshito Saitoh, Takashi Takekawa, Reiko Okubo-Suzuki, Shingo Soya, Hirofumi Nishizono, Mina Matsuo, Makoto Osanai, Masaaki Sato, Masamichi Ohkura, Junichi Nakai, Yasunori Hayashi, Takeshi Sakurai, Takashi Kitamura, Tomoki Fukai, Kaoru Inokuchi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The brain stores memories through a set of neurons known as engram cells. Here, the authors show that engram cells in the mouse hippocampus are organized into sub-ensembles representing distinct pieces of information, which are then orchestrated to c
Externí odkaz:
https://doaj.org/article/d96ece91fcd34bc6904590181d831291
Autor:
Shingo Soya, Takeshi Sakurai
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR). They are multitasking peptides involved in many physiological functions, includ
Externí odkaz:
https://doaj.org/article/ec6746ba9a744f48ae20fa737a4fb618
Autor:
Yibing Wang, Liqin Cao, Chia-Ying Lee, Tomohiko Matsuo, Kejia Wu, Greg Asher, Lijun Tang, Tsuyoshi Saitoh, Jamie Russell, Daniela Klewe-Nebenius, Li Wang, Shingo Soya, Emi Hasegawa, Yoan Chérasse, Jiamin Zhou, Yuwenbin Li, Tao Wang, Xiaowei Zhan, Chika Miyoshi, Yoko Irukayama, Jie Cao, Julian P. Meeks, Laurent Gautron, Zhiqiang Wang, Katsuyasu Sakurai, Hiromasa Funato, Takeshi Sakurai, Masashi Yanagisawa, Hiroshi Nagase, Reiko Kobayakawa, Ko Kobayakawa, Bruce Beutler, Qinghua Liu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
TMT is a chemical that evokes innate defensive behaviors yet the molecular mechanisms are not well understood. Here the authors perform a large-scale forward genetics screen in mice and identify Trpa1, a pungency/irritancy receptor, as a chemosensor
Externí odkaz:
https://doaj.org/article/8f55e531aa4244bb85f1b7f3abfc81f3
Autor:
Shingo Soya, Tohru M. Takahashi, Thomas J. McHugh, Takashi Maejima, Stefan Herlitze, Manabu Abe, Kenji Sakimura, Takeshi Sakurai
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Vigilance involves the activation of orexinergic neurons in the lateral hypothalamus (LH-ox). Here the authors report the functional role of a monosynaptically connected circuit with orexinergic neurons connected to noradrenergic neurons in the locus
Externí odkaz:
https://doaj.org/article/b6b7b0ef9da64f028089ee1720edac0e
Autor:
Kitaro Okamoto, Miwako Yamasaki, Keizo Takao, Shingo Soya, Monica Iwasaki, Koh Sasaki, Kenta Magoori, Iori Sakakibara, Tsuyoshi Miyakawa, Michihiro Mieda, Masahiko Watanabe, Juro Sakai, Masashi Yanagisawa, Takeshi Sakurai
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0164716 (2016)
How the hypothalamus transmits hunger information to other brain regions to govern whole brain function to orchestrate feeding behavior has remained largely unknown. Our present study suggests the importance of a recently found lateral hypothalamic n
Externí odkaz:
https://doaj.org/article/0ae5f649d64044d39ed5fb80f2473fa8
Autor:
Shingo Soya
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 157(6)
Central nucleus of the amygdala (CeA) has been known as an output region of emotional processing, such as fear emotion. However, recent development of technology allows us to dissect CeA neurons to find the additional role of CeA in feeding behavior,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b05e63eb9d7fc8062a2dd7aff0ed15
https://pubmed.ncbi.nlm.nih.gov/36328557
https://pubmed.ncbi.nlm.nih.gov/36328557
Autor:
Emi Hasegawa, Tohru M. Takahashi, Masayo Takahashi, Manabu Abe, Takeshi Sakurai, Hiroshi Hama, Atsushi Miyawaki, Shingo Soya, Masashi Yanagisawa, Katsuyasu Sakurai, Kiyomi Ishikawa, Genshiro A. Sunagawa, Kenji Sakimura
Publikováno v:
Nature. 583:109-114
Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity1. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits2,3. Here we show that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcdd7df4e8e4dd6adaa3d5e1f0db3452
https://doi.org/10.1038/s41586-020-2163-6
https://doi.org/10.1038/s41586-020-2163-6
Autor:
Shuntaro Uchida, Makoto Tsuda, Takeshi Sakurai, Keisuke Koga, Manabu Abe, Arisa Hirano, Shingo Soya, Yuki Saito, Kenji Sakimura
Publikováno v:
J Neurosci
During rapid eye movement (REM) sleep, anti-gravity muscle tone and bodily movements are mostly absent, because somatic motoneurons are inhibited by descending inhibitory pathways. Recent studies showed that glycine/GABA neurons in the ventromedial m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4710fcc48ec5e8872f09f16ca4540d
https://pubmed.ncbi.nlm.nih.gov/33372061
https://pubmed.ncbi.nlm.nih.gov/33372061
Publikováno v:
The Journal of Neuroscience. 37:7164-7176
Emotionally salient situations usually trigger arousal along with autonomic and neuroendocrine reactions. To determine whether the extended amygdala plays a role in sleep–wakefulness regulation, we examined the effects of optogenetic and pharmacoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4275335d23853673240953bc296fc427
https://doi.org/10.1523/jneurosci.0245-17.2017
https://doi.org/10.1523/jneurosci.0245-17.2017
Publikováno v:
Journal of Visualized Experiments.
In recent years, optogenetics has been widely used in many fields of neuroscientific research. In many cases, an opsin, such as channel rhodopsin 2 (ChR2), is expressed by a virus vector in a particular type of neuronal cells in various Cre-driver mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7462db83a5511e148845984d95e52472
https://doi.org/10.3791/58613
https://doi.org/10.3791/58613