Výsledky vyhledávání - "Shingo Okuno"

Akademický článek

Co-stimulation of CD28/CD40 signaling molecule potentiates CAR-T cell efficacy and stemness

Autor: Wannakorn Khopanlert, Pongsakorn Choochuen, Kajornkiat Maneechai, Nawaphat Jangphattananont, Socheatraksmey Ung, Shingo Okuno, Peter Steinberger, Judith Leitner, Surasak Sangkhathat, Pongtep Viboonjuntra, Seitaro Terakura, Jakrawadee Julamanee

Publikováno v: Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200837- (2024)

CD19 chimeric antigen receptor T (CD19CAR-T) cells have achieved promising outcomes in relapsed/refractory B cell malignancies. However, recurrences occur due to the loss of CAR-T cell persistence. We developed dual T/B cell co-stimulatory molecules

Externí odkaz: https://doaj.org/article/76b990e4569a498a8459de9bdd366199

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Akademický článek

Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity

Autor: Toshiyasu Sakai, Seitaro Terakura, Kotaro Miyao, Shingo Okuno, Yoshitaka Adachi, Koji Umemura, Jakrawadee Julamanee, Keisuke Watanabe, Hiroshi Hamana, Hiroyuki Kishi, Judith Leitner, Peter Steinberger, Tetsuya Nishida, Makoto Murata, Hitoshi Kiyoi

Publikováno v: Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 613-622 (2020)

An artificial T cell adaptor molecule (ATAM) was generated to improve persistence of T cell receptor (TCR) gene-transduced T (TCR-T) cells compared to such persistence in a preceding study. ATAMs are gene-modified CD3ζ with the intracellular domain

Externí odkaz: https://doaj.org/article/36662890f77a4d52a461678b98df3b75

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Akademický článek

High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype.

Autor: Daisuke Koyama, Makoto Murata, Ryo Hanajiri, Shingo Okuno, Sonoko Kamoshita, Jakrawadee Julamanee, Erina Takagi, Daiki Hirano, Kotaro Miyao, Reona Sakemura, Tatsunori Goto, Fumihiko Hayakawa, Aika Seto, Yukiyasu Ozawa, Koichi Miyamura, Seitaro Terakura, Tetsuya Nishida, Hitoshi Kiyoi

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0185213 (2017)

Regenerating islet-derived protein 3 alpha (REG3A) is a biomarker of lower gastrointestinal graft-versus-host disease (GVHD); however, the biological role of REG3A in the pathophysiology of GVHD is not understood. Here, we examined the association be

Externí odkaz: https://doaj.org/article/e238b7407fde42068b4d12ef57c9b8c6

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Data from Introduction of Genetically Modified CD3ζ Improves Proliferation and Persistence of Antigen-Specific CTLs

Autor: Hitoshi Kiyoi, Makoto Murata, Tetsuya Nishida, Tatsunori Goto, Daisuke Koyama, Reona Sakemura, Hiroyuki Kishi, Hiroshi Hamana, Keisuke Watanabe, Jakrawadee Julamanee, Shingo Okuno, Seitaro Terakura, Kotaro Miyao

The clinical efficacy of T-cell therapies based on T cells transduced with genes encoding tumor-specific T-cell receptors (TCR-T) is related to the in vivo persistence of the T cells. To improve persistence without modifying TCR affinity, we instead

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ce938229cd306a551f79a8e09cf90c
https://doi.org/10.1158/2326-6066.c.6549236.v1

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Composite CD79A/CD40 co-stimulatory endodomain enhances CD19CAR-T cell proliferation and survival

Autor: Judith Leitner, Ryo Hanajiri, Daisuke Koyama, Koji Umemura, Peter Steinberger, Tetsuya Nishida, Yoshitaka Adachi, Toshiyasu Sakai, Kotaro Miyao, Tatsunori Goto, Makoto Murata, Hitoshi Kiyoi, Michael Hudecek, Erina Takagi, Seitaro Terakura, Shingo Okuno, Jakrawadee Julamanee

Publikováno v: Mol Ther

Adoptively transferred CD19 chimeric antigen receptor (CAR) T cells have led to impressive clinical outcomes in B cell malignancies. Beyond induction of remission, the persistence of CAR-T cells is required to prevent relapse and provide long-term di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d17025c2ecc3cd680dfca7259ac4cf
https://doi.org/10.1016/j.ymthe.2021.04.038

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Spacer Length Modification Facilitates Discrimination between Normal and Neoplastic Cells and Provides Clinically Relevant CD37 CAR T Cells

Autor: Tetsuya Nishida, Yoshitaka Adachi, Makoto Murata, Koji Umemura, Kazuyuki Shimada, Jakrawadee Julamanee, Shingo Okuno, Atsushi Murase, Toshiyasu Sakai, Hitoshi Kiyoi, Tatsunori Goto, Kotaro Miyao, Seitaro Terakura

Publikováno v: The Journal of Immunology. 206:2862-2874

Despite the remarkable initial efficacy of CD19 chimeric Ag receptor T (CAR-T) cell therapy, a high incidence of relapse has been observed. To further increase treatment efficacy and reduce the rate of escape of Ag-negative cells, we need to develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::687847bdd315a5a09385b5c3ea8fbb0c
https://doi.org/10.4049/jimmunol.2000768

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Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity

Autor: Koji Umemura, Tetsuya Nishida, Hitoshi Kiyoi, Makoto Murata, Kotaro Miyao, Peter Steinberger, Jakrawadee Julamanee, Hiroshi Hamana, Hiroyuki Kishi, Judith Leitner, Yoshitaka Adachi, Shingo Okuno, Keisuke Watanabe, Toshiyasu Sakai, Seitaro Terakura

Publikováno v: Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 18, Iss, Pp 613-622 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25edc4a04ea75a8a6d59ec91f16e4dfa
http://europepmc.org/articles/PMC7509457

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