Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Shingo Kajimura"'
Autor:
Matthew C. Sinton, Praveena R. G. Chandrasegaran, Paul Capewell, Anneli Cooper, Alex Girard, John Ogunsola, Georgia Perona-Wright, Dieudonné M Ngoyi, Nono Kuispond, Bruno Bucheton, Mamadou Camara, Shingo Kajimura, Cécile Bénézech, Neil A. Mabbott, Annette MacLeod, Juan F. Quintana
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue, and is proposed to be competent for forward transmission. The interaction between parasites, adipose tissue, and the local immune system is likely to drive the
Externí odkaz:
https://doaj.org/article/34a1cb8324534887a960552c5aa36b6f
Autor:
Matthew C. Sinton, Praveena R. G. Chandrasegaran, Paul Capewell, Anneli Cooper, Alex Girard, John Ogunsola, Georgia Perona-Wright, Dieudonné M Ngoyi, Nono Kuispond, Bruno Bucheton, Mamadou Camara, Shingo Kajimura, Cécile Bénézech, Neil A. Mabbott, Annette MacLeod, Juan F. Quintana
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/51277c3f39fe43e394b3a5b030e6202a
Autor:
Tatsuya Yoshizawa, Yoshifumi Sato, Shihab U. Sobuz, Tomoya Mizumoto, Tomonori Tsuyama, Md. Fazlul Karim, Keishi Miyata, Masayoshi Tasaki, Masaya Yamazaki, Yuichi Kariba, Norie Araki, Eiichi Araki, Shingo Kajimura, Yuichi Oike, Thomas Braun, Eva Bober, Johan Auwerx, Kazuya Yamagata
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Sirtuins have been reported to positively regulate brown adipose tissue thermogenesis. Here the authors report that brown adipocytic SIRT7 suppresses whole-body energy expenditure and thermogenesis in mice, potentially by attenuating batokine gene ex
Externí odkaz:
https://doaj.org/article/7b51c06d17574f72b35f0b3884a3c7fe
Autor:
Yohko Yoshida, Ippei Shimizu, Atsuhiro Shimada, Keita Nakahara, Sachiko Yanagisawa, Minoru Kubo, Shinji Fukuda, Chiharu Ishii, Hiromitsu Yamamoto, Takamasa Ishikawa, Kuniyuki Kano, Junken Aoki, Goro Katsuumi, Masayoshi Suda, Kazuyuki Ozaki, Yutaka Yoshida, Shujiro Okuda, Shigeo Ohta, Shiki Okamoto, Yasuhiko Minokoshi, Kanako Oda, Toshikuni Sasaoka, Manabu Abe, Kenji Sakimura, Yoshiaki Kubota, Norihiko Yoshimura, Shingo Kajimura, Maria Zuriaga, Kenneth Walsh, Tomoyoshi Soga, Tohru Minamino
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Low body temperature predicts a poor outcome in patients with heart failure, but the underlying pathological mechanisms and implications are largely unknown. Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and
Externí odkaz:
https://doaj.org/article/47e7cf28377a4d3a94aefb37d6721e18
Autor:
Bo Wang, Evangelia E. Tsakiridis, Shuman Zhang, Andrea Llanos, Eric M. Desjardins, Julian M. Yabut, Alexander E. Green, Emily A. Day, Brennan K. Smith, James S. V. Lally, Jianhan Wu, Amogelang R. Raphenya, Krishna A. Srinivasan, Andrew G. McArthur, Shingo Kajimura, Jagdish Suresh Patel, Michael G. Wade, Katherine M. Morrison, Alison C. Holloway, Gregory R. Steinberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Chlorpyrifos is a widely-used pesticide and a common residue on vegetables and fruits. Here the authors show that at non-neurotoxic doses, chlorpyrifos reduces energy expenditure, by inhibiting diet induced thermogenesis, and promotes obesity and ins
Externí odkaz:
https://doaj.org/article/17efe75eaf7346188e0d2025067371da
Autor:
Yuko Nabatame, Tetsuya Hosooka, Chikako Aoki, Yusei Hosokawa, Makoto Imamori, Yoshikazu Tamori, Yuko Okamatsu‐Ogura, Takeshi Yoneshiro, Shingo Kajimura, Masayuki Saito, Wataru Ogawa
Publikováno v:
Journal of Diabetes Investigation, Vol 12, Iss 7, Pp 1144-1151 (2021)
Abstract Aims/Introduction Brown adipose tissue (BAT) utilizes large amounts of fuel for thermogenesis, but the mechanism by which fuel substrates are switched in response to changes in energy status is poorly understood. We have now investigated the
Externí odkaz:
https://doaj.org/article/4065e77cfe1f45e498393d0a6745c114
Autor:
Jin-Seon Yook, Shingo Kajimura
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Brown adipose tissue (BAT) dissipates energy in the form of heat and functions as a metabolic sink for lipids, glucose, and branched-chain amino acids. Enhanced BAT thermogenesis is thought to tightly couple with beneficial energy metabolism. However
Externí odkaz:
https://doaj.org/article/03c6ebf2026843a2952fe79f4f476b6f
Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
Autor:
Jacquelyn M. Walejko, Bridgette A. Christopher, Scott B. Crown, Guo-Fang Zhang, Adrian Pickar-Oliver, Takeshi Yoneshiro, Matthew W. Foster, Stephani Page, Stephan van Vliet, Olga Ilkayeva, Michael J. Muehlbauer, Matthew W. Carson, Joseph T. Brozinick, Craig D. Hammond, Ruth E. Gimeno, M. Arthur Moseley, Shingo Kajimura, Charles A. Gersbach, Christopher B. Newgard, Phillip J. White, Robert W. McGarrah
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Systemic modulation of branched-chain keto acid (BCKA) metabolism alters cardiac health. Here, the authors define the major fates of BCKA in the heart and demonstrate that acute exposure to BCKA levels found in obesity activates cardiac protein synth
Externí odkaz:
https://doaj.org/article/13e6e6480fe7436f81d6416509424af3
Autor:
Naofumi Yoshida, Tomoya Yamashita, Tatsunori Osone, Tetsuya Hosooka, Masakazu Shinohara, Seiichi Kitahama, Kengo Sasaki, Daisuke Sasaki, Takeshi Yoneshiro, Tomohiro Suzuki, Takuo Emoto, Yoshihiro Saito, Genki Ozawa, Yushi Hirota, Yasuyuki Kitaura, Yoshiharu Shimomura, Yuko Okamatsu-Ogura, Masayuki Saito, Akihiko Kondo, Shingo Kajimura, Takeshi Inagaki, Wataru Ogawa, Takuji Yamada, Ken-ichi Hirata
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103342- (2021)
Summary: The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels of circulating branched-chain amino acids
Externí odkaz:
https://doaj.org/article/54ef087fe8ce4247835125bd4322e949
Autor:
Kazuki Tajima, Kenji Ikeda, Yuji Tanabe, Ella A. Thomson, Takeshi Yoneshiro, Yasuo Oguri, Marc D. Ferro, Ada S. Y. Poon, Shingo Kajimura
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Cardiovascular risks of cold exposure and the subsequent activation of the β3-AR pathway limit the application of beige fat thermogenesis for the treatment of obesity. Here, the authors show that optogenetics light-activated Ca2+ cycling in adipocyt
Externí odkaz:
https://doaj.org/article/c6fe438eef6244abb2103d07bbb951d4