Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Shingo Hotta"'
Autor:
Issei Nakade, Yuto Tamura, Fuyu Hashimoto, Yuko Ariza, Shingo Hotta, Hirofumi Fujigaya, Suishin Arai, Mai Taniguchi, Hodaka Ogawa, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Akihiro Ishizu
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background Bruton’s tyrosine kinase (Btk) is an enzyme expressed in leukocytes other than T lymphocytes and plasma cells and involved in B-cell receptor- and Fcγ receptor (FcγR)-mediated signal transduction. Btk inhibitors potentially su
Externí odkaz:
https://doaj.org/article/060a526975d94c7b99f7ab3eb6855475
Autor:
Ryohei Kozaki, Tomoko Yasuhiro, Hikaru Kato, Jun Murai, Shingo Hotta, Yuko Ariza, Shunsuke Sakai, Ryu Fujikawa, Takao Yoshida
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282166 (2023)
Tirabrutinib is a highly selective Bruton's tyrosine kinase (BTK) inhibitor used to treat hematological malignancies. We analyzed the anti-tumor mechanism of tirabrutinib using phosphoproteomic and transcriptomic methods. It is important to check the
Externí odkaz:
https://doaj.org/article/ce0a04b154294e48a34fb37c7e65fd46
Autor:
Hidemichi Murata, Shingo Hotta, Eiji Sawada, Hisao Yamamura, Susumu Ohya, Satomi Kita, Takahiro Iwamoto, Yuji Imaizumi
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 3, Pp 373-377 (2010)
The rise of Ca2+ concentration ([Ca2+] i ) by reducing external Na+ in urinary bladder smooth muscle cells (UBSMCs) from transgenic mice overexpressing Na+/Ca2+ exchanger type-1.3 (NCX1.3tg/tg) was about 4 times as large as that in the wild-type (WT)
Externí odkaz:
https://doaj.org/article/41fc779db1834e11b91c2d9660871238
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 1, Pp 121-126 (2007)
We examined the effects of methyl-β-cyclodextrin (MβCD) on Ca2+-induced Ca2+ release (CICR) in smooth muscle cells (SMCs) of mouse urinary bladder (UB). Short depolarization of UBSMCs under voltage-clamp elicited several local Ca2+ transients (Ca2+
Externí odkaz:
https://doaj.org/article/f2c1f676ee514715914b4bbc7f1fdcb7
Autor:
Shingo, HOTTA
Publikováno v:
IPSS Working Paper Series = IPSS Working Paper Series. 63:1-17
Autor:
Arisu Uchida, Yusuke Kawano, Genma Kubota, Rintaro Fujii, Masaki Ihara, Shingo Hotta, Midori Sekine, Kai Kudoh
Publikováno v:
Journal of Bioscience and Bioengineering. 123:590-596
1-Deoxy-d-xylulose 5-phosphate synthase (DXS) is a rate-limiting enzyme in the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway, which is responsible for the production of precursors of all isoprenoids. In a previous study, we had examined the overe
Publikováno v:
Journal of Bioscience and Bioengineering. 118:20-28
Cyanobacteria have recently been receiving considerable attention owing to their potential as photosynthetic producers of biofuels and biomaterials. Here, we focused on the production of isoprenoids by cyanobacteria, and aimed to provide insight into
Autor:
Yuji Imaizumi, William C. Cole, Shingo Hotta, Satomi Kita, Takahiro Iwamoto, Hisao Yamamura, Yoshiaki Suzuki, Susumu Ohya, Hidemichi Murata
Publikováno v:
American Journal of Physiology-Cell Physiology. 305:C299-C308
The Na+/Ca2+exchanger (NCX) is thought to be a key molecule in the regulation of cytosolic Ca2+dynamics. The relative importance of the two Ca2+transport modes of NCX activity leading to Ca2+efflux (forward) and influx (reverse) in smooth muscle, how
Autor:
Tomoko, Yasuhiro, Wako, Sawada, Christian, Klein, Ryohei, Kozaki, Shingo, Hotta, Toshio, Yoshizawa
Publikováno v:
Leukemialymphoma. 58(3)
The activated B-cell diffuse large B-cell-like lymphoma (ABC-DLBCL) correlates with poor prognosis. The B-cell receptor signaling pathway is known to be dysregulated in NHL/CLL and given BTK is a downstream mediator of BCR signaling, BTK constitutes
Autor:
Eiji Sawada, Susumu Ohya, Yuji Imaizumi, Hidemichi Murata, Shingo Hotta, Hisao Yamamura, Takahiro Iwamoto, Satomi Kita
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 3, Pp 373-377 (2010)
The rise of Ca2+ concentration ([Ca2+] i ) by reducing external Na+ in urinary bladder smooth muscle cells (UBSMCs) from transgenic mice overexpressing Na+/Ca2+ exchanger type-1.3 (NCX1.3tg/tg) was about 4 times as large as that in the wild-type (WT)