Výsledky vyhledávání - "Shingo, Toji"

Akademický článek

HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses

Autor: Vitaly Kochin, Takayuki Kanaseki, Serina Tokita, Sho Miyamoto, Yosuke Shionoya, Yasuhiro Kikuchi, Daichi Morooka, Yoshihiko Hirohashi, Tomohide Tsukahara, Kazue Watanabe, Shingo Toji, Yasuo Kokai, Noriyuki Sato, Toshihiko Torigoe

Publikováno v: OncoImmunology, Vol 6, Iss 4 (2017)

This study focused on HLA-A24 and comprehensively analyzed the ligandome of colon and lung cancer cells without the use of MHC-binding in silico prediction algorithms. Affinity purification using the antibody specific to HLA-A24 followed by LC–MS/M

Externí odkaz: https://doaj.org/article/7afea113c05647e4a474bb5700a217f7

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Akademický článek

Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy.

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0171460 (2017)

Lung cancer is one of the most common malignancies with a high rate of mortality. Lung cancer stem-like cells (CSCs)/ cancer-initiating cells (CICs) play major role in resistance to treatments, recurrence and distant metastasis and eradication of CSC

Externí odkaz: https://doaj.org/article/5f0074ef43564f9492250157d1806934

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Development of a T-cell receptor multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells

Autor: Takeshi Terui, Yoshihiko Hirohashi, Shogo Saitoh, Terufumi Kubo, Munehide Nakatsugawa, Toshihiko Torigoe, Takayuki Kanaseki, Shingo Toji, Noriyuki Sato, Kazue Watanabe, Hidekazu Kameshima, Tomohide Tsukahara

Publikováno v: Cancer Science

For efficacy of peptide vaccination immunotherapy for patients with cancer, endogenous expression of the target peptide/human leukocyte antigen (HLA) on cancer cells is required. However, it is difficult to evaluate the expression status of a peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44062df0a4fe69df84891f6021e2d8e3
https://doi.org/10.1111/cas.13854

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HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses

Autor: Yasuo Kokai, Yasuhiro Kikuchi, Serina Tokita, Vitaly Kochin, Takayuki Kanaseki, Yosuke Shionoya, Noriyuki Sato, Toshihiko Torigoe, Yoshihiko Hirohashi, Daichi Morooka, Sho Miyamoto, Tomohide Tsukahara, Kazue Watanabe, Shingo Toji

Publikováno v: OncoImmunology, Vol 6, Iss 4 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039600191451275b90788faa02c0aa4d
https://europepmc.org/articles/PMC5433517/

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Specific Targeting of a Naturally Presented Osteosarcoma Antigen, Papillomavirus Binding Factor Peptide, Using an Artificial Monoclonal Antibody

Autor: Hiroshi Matsumiya, Toshihiko Torigoe, Noriyuki Sato, Shingo Ichimiya, Vitaly Kochin, Masanori Kyono, Makoto Emori, Tadashi Hasegawa, Tetsuo Himi, Takahisa Hirano, Norihiro Muroi, Toshihiko Yamashita, Takuro Wada, Hiroko Asanuma, Shingo Toji, Keiji Yamashita, Kenji Murata, Kazue Watanabe, Tomohide Tsukahara

Publikováno v: Journal of Biological Chemistry. 289:22035-22047

Osteosarcoma is a rare but highly malignant tumor occurring most frequently in adolescents. The prognosis of non-responders to chemotherapy is still poor, and new treatment modalities are needed. To develop peptide-based immunotherapy, we previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fda48d5a03d66f06a97d275159446e1
https://doi.org/10.1074/jbc.m114.568725

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Identification of a novel HLA-A*24:02-restricted adenovirus serotype 11-specific CD8+ T-cell epitope for adoptive immunotherapy

Autor: Yoshinori Ito, Tomoki Naoe, Jun-ichi Kawada, Seitaro Terakura, Tomonori Kato, Yozo Nakazawa, Nobuhiko Imahashi, Tetsuya Nishida, Shingo Toji, Makoto Murata, Susumu Suzuki

Publikováno v: Molecular Immunology. 56:399-405

Subgroup B adenovirus serotype 11 (Ad11) occasionally causes fatal infections in immunocompromised patients. The present study describes a novel Ad11 epitope presented by HLA-A*24:02 that could be used for adoptive immunotherapy. Ten synthetic Ad11 h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f92003ccb71088cc0c0aba0ffa7af1
https://doi.org/10.1016/j.molimm.2013.05.232

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Reduced Frequency, Diversity, and Function of Human T Cell Leukemia Virus Type 1-Specific CD8+ T Cell in Adult T Cell Leukemia Patients

Autor: Xiao-Fang Che, Hiroshi Fujiwara, Kakushi Matsushita, Koichi Haraguchi, Naomichi Arima, Heiichiro Hamada, Izumi Masamoto, Shunro Sonoda, Masahito Tokunaga, Susumu Suzuki, Shingo Toji, Kimiharu Uozumi, Masaki Akimoto, Toshiro Takezaki, Tomohiro Kozako

Publikováno v: The Journal of Immunology. 177:5718-5726

Human T cell lymphotropic virus type 1 (HTLV-1)-specific CTL are thought to be immune effectors that reduce the risk of adult T cell leukemia (ATL). However, in vivo conditions of anti-HTLV-1 CTL before and after ATL development have yet to be determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a33d45b3c9a1047bddcb7ebefd264f
https://doi.org/10.4049/jimmunol.177.8.5718

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Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest

Autor: Hiroshi Nojima, Naohisa Yoshioka, Hiroaki Onda, Shingo Toji, Tomoyuki Funatsu, Katsuyuki Tamai, Ippei Nagamori, Masafumi Watanabe, Norikazu Yabuta

Publikováno v: Nucleic Acids Research

We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found that there are two kinds of G0 phases caused by ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202579e4bbf66a823fd812e8f5962d20
http://europepmc.org/articles/PMC1635288

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DNA polymerase lambda directly binds to proliferating cell nuclear antigen through its confined C-terminal region

Autor: Takaya Yazaki, Asami Sato, Katsuyuki Tamai, Ayako Nakamura, Osamu Koiwai, Noriko Shimazaki, Shingo Toji, Takashi Kubota, Shunsuke Kurei

Publikováno v: Genes to Cells. 10:705-715

DNA polymerase lambda (Pol lambda) was recently identified as a new member of the family X of DNA polymerases. Here, we show that Pol lambda directly binds to proliferating cell nuclear antigen (PCNA), an auxiliary protein for DNA replication and rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0b746ce0873499da785ceae7cd25d2e
https://doi.org/10.1111/j.1365-2443.2005.00868.x

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Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone

Autor: Kiyoko Fujita, Seiichiro Fujisaki, Shingo Toji, Katsuyuki Tamai, Takashi Kubota, Takahide Hayano, Shirou Ibe, Yuko Ohta, Noriko Shimazaki, Osamu Koiwai

Publikováno v: Genes to Cells. 8:559-571

Background: Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase that enhances the Ig and TcR gene diversity in the N region at the junctions of variable (V), diversity (D) and joining (J) segments in B- and T-cells. TdT synthesizes the N r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7530f4cf8074eb5756816c69f99f67e
https://doi.org/10.1046/j.1365-2443.2003.00656.x

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