Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Shing-Mei Hwang"'
Autor:
Kevin L. Salyers, James Samanen, R. Curtis Haltiwanger, M.W. Lark, Leonard M. Azzarano, Irene N. Uzinskas, Karl F. Erhard, Robert N. Willette, Kyung O. Johanson, Catherine J. Gress, Stephen T Ross, Tian Li Yue, Keith W. Ward, William F. Huffman, Russell D. Cousins, Dirk A. Heerding, David J. Rieman, Shing Mei Hwang, Chet Kwon, Brian R. Smith, Ian E. James, William H. Miller, Catherine C.K. Yuan, Dennis T. Takata, Manley Peter J
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1483-1486
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b020a8d8d76827308cf4beb670e93f46
https://doi.org/10.1016/s0960-894x(03)00102-1
https://doi.org/10.1016/s0960-894x(03)00102-1
Autor:
Maxine Gowen, Catherine J. Gress, Shing Mei Hwang, Michael W. Lark, Michael S. McQueney, Ian E. James, Robert W. Marquis, Simon M. Blake, Ru Yu, Daniel F. Veber, Hye-Ja Oh, Denise Zembryki, Thaddeus A. Tomaszek, Dennis S. Yamashita
Publikováno v:
Journal of Biological Chemistry. 276:11507-11511
Cathepsins K and L are related cysteine proteases that have been proposed to play important roles in osteoclast-mediated bone resorption. To further examine the putative role of cathepsin L in bone resorption, we have evaluated selective and potent i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892b89bfe824acabaf8fa273601f5802
https://doi.org/10.1074/jbc.m010684200
https://doi.org/10.1074/jbc.m010684200
Autor:
Irene N. Uzinskas, Russell D. Cousins, Bondinell William E, Linda S. Barton, M. Amparo Lago, Brian R. Smith, Chet Kwon, Richard M. Keenan, Shing-Mei Hwang, William H. Miller, Catherine C.K. Yuan, Daniel F. Eppley, Thomas T. Nguyen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1801-1806
A peptide RGD analog containing a novel 2-aminopyridine arginine mimetic was discovered to have good affinity and selectivity for the vitronectin receptor. Incorporation of the 2-aminopyridine arginine mimetic into the 3-oxo-1,4-benzodiazepine-2-acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104fdad5eb16b8a7559d8072d5850c24
https://doi.org/10.1016/s0960-894x(99)00282-6
https://doi.org/10.1016/s0960-894x(99)00282-6
Autor:
David J. Rieman, William F. Huffaman, Kevin L. Salyers, Richard M. Keenan, Michael W. Lark, Janice A. Vasko-Moser, Thomas W. Ku, Maxine Gowen, Leonard M. Azzarano, Karl F. Erhard, Stephen T. Ross, Denise Zembryki, Bradbeer Jeremy N, Bondinell William E, Shing-Mei Hwang, William H. Miller, Kenneth A. Newlander, George B. Stroup, Beata Lechowska, Fred H. Drake, Keith W. Ward, Kyung O. Johanson, Brian R. Smith, Paula C. Adams, Ian E. James, R. Curtis Haltiwanger, Russell D. Cousins, Dalia R. Jakas, Sandra J. Hoffman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1807-1812
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bebe15e69e0b6c6398f79a6e04504c
https://doi.org/10.1016/s0960-894x(99)00283-8
https://doi.org/10.1016/s0960-894x(99)00283-8
Autor:
Shing Mei Hwang, Qing Dong, Iwao Ojima, Subrata Chakravarty, Ellinor I.B. Peerschke, Angela S. Wong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1941-1946
A new series of peptide hybrids is developed as highly potent and selective antagonists of the GPIIb/IIIa receptor through rational modification of the RGDX sequence. Structure-activity relationships of these peptide hybrids have disclosed the import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9302ab8355a8602cfc14e5984dc6b844
https://doi.org/10.1016/0960-894x(95)00329-r
https://doi.org/10.1016/0960-894x(95)00329-r
Publikováno v:
Biochemistry. 31:4046-4053
Recent studies in rat basophilic leukemia cells (RBL-2H3) have shown that two pharmacological agents, ionomycin and thapsigargin, induce leukotriene C4 production and translocation of 5-lipoxygenase from cytosol to membrane, primarily by causing an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e689339ce5acc9b9c169f353fbfeca8
https://doi.org/10.1021/bi00131a021
https://doi.org/10.1021/bi00131a021
Autor:
Robert W. Marquis, Dennis S. Yamashita, Thaddeus A. Tomaszek, Simon M. Blake, Priscilla H. Offen, Martha S. Head, Shing-Mei Hwang, Ren Xie, Attiq Rahman, Scott K. Thompson, Ru Yu, Jin Zeng, Ian E. James, Robert E. Lee Trout, Cummings Maxwell D, Michael A. Lark, Daniel F. Veber, Catherine J. Gress
Publikováno v:
Journal of medicinal chemistry. 48(22)
The extension of a previously reported cathepsin K azepanone-based inhibitor template to the design and synthesis of potent and selective inhibitors of the homologous cysteine protease cathepsin L is detailed. Structure-activity studies examining the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55b20e3835b8f957914448867db4290
https://pubmed.ncbi.nlm.nih.gov/16250645
https://pubmed.ncbi.nlm.nih.gov/16250645
Autor:
Fred H. Drake, Michael W. Lark, Stephen Holmes, David J. Rieman, Ian E. James, Maxine Gowen, Reina Ahern, Shing Mei Hwang, Daniel F. Veber, Scott D. Thompson, R.A. Dodds, Janice R. Connor
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 16(3)
Cathepsin K is a member of the papain superfamily of cysteine proteases and has been proposed to play a pivotal role in osteoclast-mediated bone resorption. We have developed a sensitive cytochemical assay to localize and quantify osteoclast cathepsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae0dbacdb03968160f5c242a4bddc46
https://pubmed.ncbi.nlm.nih.gov/11277265
https://pubmed.ncbi.nlm.nih.gov/11277265
Autor:
William H. Miller, David J. Rieman, Ian E. James, Rasesh Kapadia, Xiaoguang Liang, R.A. Dodds, Kevin L. Salyers, Beata Lechowska, George B. Stroup, Shing Mei Hwang, Maxine Gowen, William F. Huffman, Sandra J. Hoffman, Brian R. Smith, Michael W. Lark, Keith W. Ward
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 16(2)
An orally active, nonpeptide Arg-Gly-Asp (RGD) mimetic alpha(v)beta3 antagonist, (S)-3-Oxo-8-[2-[6-(methylamino)-pyridin-2-yl]-1-ethoxy]-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid (compound 1), has been generated, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359499febac34810827d1033b88baca1
https://pubmed.ncbi.nlm.nih.gov/11204432
https://pubmed.ncbi.nlm.nih.gov/11204432
Autor:
Elizabeth Lee-Rykaczewski, Ian E. James, Denise Zembryki, Michael W. Lark, Thaddeus A. Tomaszek, Pietro Belfiore, Maxine Gowen, Shing Mei Hwang
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14(9)
A human in vitro resorption assay has been developed using osteoclastoma-derived osteoclasts and used to evaluate novel antiresorptive agents including antagonists of the alphavbeta3 integrin, and inhibitors of cathepsin K and the osteoclast ATPase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b51a48f5d7f29acf1af3646b8840b91
https://pubmed.ncbi.nlm.nih.gov/10469285
https://pubmed.ncbi.nlm.nih.gov/10469285