Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Shing M. Lee"'
Publikováno v:
Health and Quality of Life Outcomes, Vol 17, Iss 1, Pp 1-6 (2019)
Abstract Background Cancer treatments are associated with a multitude of adverse events (AEs). While both nurses and physicians are involved in patient care delivery and AE assessment, very few studies have examined the differences between nurses’
Externí odkaz:
https://doaj.org/article/7bf5334fb12e48bf9963b2a78b751632
Autor:
Shing M. Lee, Weijia Fan, Aijin Wang, Riha Vaidya, Mary W. Redman, Scott N. Gettinger, Lyudmila Bazhenova, Roy S. Herbst, Dawn L. Hershman, Joseph M. Unger
Publikováno v:
JCO Clinical Cancer Informatics.
PURPOSE Clinical trial adverse event (AE) data are increasingly complex and high-dimensional, especially for trials evaluating novel targeted agents and immunotherapies. Standard approaches to summarize and analyze AEs remain generally tabular, faili
Autor:
Joseph M. Unger, Riha Vaidya, Kathy S. Albain, Michael LeBlanc, Lori M. Minasian, Carolyn C. Gotay, N. Lynn Henry, Michael J. Fisch, Shing M. Lee, Charles D. Blanke, Dawn L. Hershman
Publikováno v:
Journal of Clinical Oncology. 40:1474-1486
PURPOSE Women have more adverse events (AEs) from chemotherapy than men, but few studies have investigated sex differences in immune or targeted therapies. We examined AEs by sex across different treatment domains. METHODS We analyzed treatment-relat
Publikováno v:
JCO Precision Oncology. :1024-1034
PURPOSE Simulation studies have shown that novel designs such as the continual reassessment method and the Bayesian optimal interval (BOIN) design outperform the 3 + 3 design by recommending the maximum tolerated dose (MTD) more often, using less pat
Autor:
Nina Patel, Pamela Maino, Mary Salvatore, Shing M. Lee, Aijin Wang, Kathleen M. Capaccione, Maria Padilla, John H. M. Austin
Publikováno v:
Clinical Imaging. 77:287-290
BACKGROUND Chest CT scans are routinely obtained to monitor disease progression in pulmonary fibrosis. However, radiologists do not employ a standardized system for quantitative description of the severity of the disease. Development and validation o
Publikováno v:
Journal of the American Medical Informatics Association : JAMIA
Hundreds of interventional clinical trials have been launched in the United States to identify effective treatment strategies for combating the coronavirus disease 2019 (COVID-19) pandemic. However, to date, only a small fraction of these trials have
Autor:
Brian A. Van Tine, Gulam Abbas Manji, Gary K. Schwartz, Angela C. Hirbe, Shing M. Lee, Andrew X. Chen, Jaya Sarin Pradhan, Raul Rabadan, Ilenia Pellicciotta, Alexander G. Raufi
Publikováno v:
Clinical Cancer Research. 27:5519-5527
Purpose: To evaluate the safety and tolerability in phase I first-in-human combination therapy with pexidartinib, an inhibitor of colony-stimulating factor-1 receptor, and sirolimus, an mTOR inhibitor, to target tumor-associated macrophage (TAM) pola
Autor:
Katherine D. Crew, Melissa K. Accordino, Alessandro Marone, Shing M. Lee, Lauren Franks, Andreas H. Hielscher, Kevin Kalinsky, Julia E. McGuinness, Dawn L. Hershman, Mirella L. Altoe, Meghna S. Trivedi, Mariella Tejada, Hyun K. Kim
Publikováno v:
Breast Cancer Research and Treatment. 189:297-304
Diffuse optical tomography breast imaging system (DOTBIS) non-invasively measures tissue concentration of hemoglobin, which is a potential biomarker of short-term response to neoadjuvant chemotherapy. We evaluated whether DOTBIS-derived measurements
Publikováno v:
Statistics in medicine. 41(29)
The growing interest in new classes of anti-cancer agents, such as molecularly-targeted therapies and immunotherapies with modes of action different from those of cytotoxic chemotherapies, has changed the dose-finding paradigm. In this setting, the o
Autor:
Alex Butler, Shing M Lee, Jae Hyun Kim, Latoya A. Stewart, Hao Liu, Chunhua Weng, Cynthia Sung, Casey N. Ta, Cong Liu, Anna Ostropolets, Lyudmila Ena, Patrick B. Ryan, Mitchell S.V. Elkind, Junghwan Lee, James R. Rogers
Publikováno v:
Journal of the American Medical Informatics Association : JAMIA
Journal of the American Medical Informatics Association
Journal of the American Medical Informatics Association
Objective This research aims to evaluate the impact of eligibility criteria on recruitment and observable clinical outcomes of COVID-19 clinical trials using electronic health record (EHR) data. Materials and Methods On June 18, 2020, we identified f