Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Shinde, Anil Karbhari"'
Autor:
Ramkumar Subramanian, Vijay Benade, Arunkumar Manoharan, Narender Ganuga, Ramakrishna Nirogi, Rajesh Kumar Badange, Surendra Petlu, Venkat Jasti, Rajesh Babu Medapati, Gopinadh Bhyrapuneni, Shinde Anil Karbhari, Venkata Ramalingayya Grandhi, Renny Abraham, Pradeep Jayarajan, Sudhakar Gandipudi
Publikováno v:
Journal of Psychopharmacology. 35:713-729
Background: Central histamine H3 receptors are a family of presynaptic auto and heteroreceptors. Blockade of the presynaptic H3 receptors activates the downstream pathway(s) involved in the processes of learning and memory, making it a potential ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1920b53ccf7febfacf8c7c3e31f92d
https://doi.org/10.1177/0269881120986418
https://doi.org/10.1177/0269881120986418
Autor:
Shinde Anil Karbhari, Lakshmi Prasanna Rayapati, Prathyusha Chunduru, Ilayaraja Kalaikadhiban, Naga Surya Prakash Padala, Devender Reddy Ajjala, Ramakrishna Nirogi
Publikováno v:
Bioanalysis. 12:533-544
Background: A LC–MS/MS method was validated for the quantification of SUVN-G3031, a novel H3 receptor inverse agonist in clinical development for the treatment of patients with narcolepsy, with and without cataplexy. Methodology: SUVN-G3031 was ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e906493acbb57f0e679c1cfc0ac2cc7
https://doi.org/10.4155/bio-2020-0020
https://doi.org/10.4155/bio-2020-0020
Autor:
Jagadeesh Babu Thentu, Nageswararao Muddana, Renny Abraham, Raghava Choudary Palacharla, Srinivasa Rao Ravella, Ramkumar Subramanian, Venkat Reddy Mekala, Shinde Anil Karbhari, Narsimha Bogaraju, Abdul Rasheed Mohammed, Gopinadh Bhyrapuneni, Ramakrishna Nirogi, Venkat Jasti
Publikováno v:
Journal of Medicinal Chemistry. 63:2833-2853
A series of chemical optimizations guided by in vitro affinity at the α4β2 receptor in combination with selectivity against the α3β4 receptor, pharmacokinetic evaluation, and in vivo efficacy in a forced swim test resulted in identification of 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ac0220a5003d1184e2ad4655e6b000
https://doi.org/10.1021/acs.jmedchem.9b00790
https://doi.org/10.1021/acs.jmedchem.9b00790
Autor:
Veena Reballi, Jagadeesh Babu Thentu, Vijay Benade, Ramakrishna Nirogi, Nageswara Rao Muddana, Abdul Rasheed Mohammed, Ramkumar Subramanian, Sravanthi Manchineella, Narendra Kagita, Rajesh Kumar Badange, Kumar Bojja, Raghava Choudary Palacharla, Sivasekhar Yarra, Pradeep Jayarajan, Shinde Anil Karbhari, Pramod Kumar Achanta, Bujji Babu Lingavarapu, Mallikarjuna Rao Doguparthi
Publikováno v:
ChemMedChem. 17
A series of chemical optimizations, which was guided by in vitro affinity at histamine H3 receptor (H3 R), modulation of lipophilicity, ADME properties and preclinical efficacy resulted in the identification of 1-[2-(1-cyclobutylpiperidin-4-yloxy)-6,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b45baa35dad5d12cb26ccb67e3120bae
https://doi.org/10.1002/cmdc.202100583
https://doi.org/10.1002/cmdc.202100583
Akademický článek
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Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Mohammed Abdul Rasheed, Ramkumar Subramanian, Ramakrishna Nirogi, Shinde Anil Karbhari, Venkat Jasti, Jyothsna Ravulu, Vijay Benade, Gopinadh Bhyrapuneni, Satish Jetta, Rajesh Kumar Badange
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dbb95814165c20c9fecee764340d1ba
https://doi.org/10.1002/alz.039283
https://doi.org/10.1002/alz.039283
Autor:
Renny Abraham, Vijay Benade, Shinde Anil Karbhari, Venkat Jasti, Pradeep Jayarajan, Jyothsna Ravulu, Vinod Kumar Goyal, Ramakrishna Nirogi
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::669114a96314fc60600d1e7f274fef64
https://doi.org/10.1002/alz.039303
https://doi.org/10.1002/alz.039303
Autor:
Surendra Petlu, Rajesh Kumar Badange, Ramkumar Subramanian, Nageswara Rao Muddana, Venkatesh Kamuju, Saivishal Daripelli, Shinde Anil Karbhari, Venkat Reddy Mekala, Gopinadh Bhyrapuneni, Ramakrishna Nirogi, Vijay Benade, Venkat Jasti, Pradeep Jayarajan
Publikováno v:
Psychopharmacology. 238(6)
Samelisant (SUVN-G3031) is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Pharmacological and neurochemical characterisation to support the utility of Samelisant (SUVN-G3031) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a347932e5ae7ac95612051bde18b53f
https://pubmed.ncbi.nlm.nih.gov/33550481
https://pubmed.ncbi.nlm.nih.gov/33550481
Autor:
Pooja Singh, Nageswararao Muddana, Ramakrishna Nirogi, Narsimha Bogaraju, Abdul Rasheed Mohammed, Srinivasa Rao Ravella, Raghava Choudary Palacharla, Ramkumar Subramanian, Shankar Reddy Gagginapally, Shinde Anil Karbhari, Vanaja Reddy Middekadi, Durga Malleshwari Kancharla, Pradeep Jayarajan, Vijay Benade, Sumit Raosaheb Birangal
Publikováno v:
Journal of Medicinal Chemistry. 61:4993-5008
Alzheimer’s disease (AD) is a neurodegenerative disorder that has a higher prevalence and incidence in people older than 60 years. The need for improved AD therapies is unmet as the current therapies are symptomatic with modest efficacy. Partial ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99c12a66cd15dcfd5d91660e6cac491a
https://doi.org/10.1021/acs.jmedchem.8b00457
https://doi.org/10.1021/acs.jmedchem.8b00457