Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Shinano Isawa"'
Autor:
Yuji Kumagai, Tomoe Fujita, Kazuhiro Tateoka, Shinano Isawa, Mika Sawada, Yuichi Suzuki, Kazuo Yago, Shinichi Yokota, Takashi Shoda
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 33:205-213
Objectives: Tibolone (KB-889) is a novel compound that possesses tissue-specific hormonal effects. We investigated the pharmacokinetics of tibolone in postmenopausal women in four pharmacokinetic studies, namely a dose linearity study, a multiple dos
Autor:
Tomoe Watanabe, Mika Sawada, Mitsukuni Murasaki, Shinano Isawa, Shinichi Yokota, Ayako Kannami, Yuji Kumagai, Keiko Nakai
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 29:699-705
Mizolastine is a new peripherally acting histamine H1 receptor antagonist, which is metabolized by the liver both through conjugation and by cytochrome-P450 (CYP). It is reported that aging affects the pharmacokinetics of some drugs metabolized by th
Autor:
Shinichi Yokota, Takayuki Yuasa, Shinano Isawa, Masato Iwamoto, Kei Akimoto, Yuji Kumagai, Mitsutomo Uchiumi, Masao Iwano, Mitsukuni Murasaki
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 28:693-702
To investigate the effects of aging on the pharmacokinetics of MCI-186, a novel agent for cerebrovascular disease, we performed a comparative study in parallel groups of young and elderly subjects. The subjects were 14 healthy male volunteers, 7 form
Autor:
Masako Okawa, Makihiko Suzuki, Mitsukuni Murasaki, Jun Ishigooka, Hideo Muraoka, Shinano Isawa
Publikováno v:
Psychiatry and clinical neurosciences. 53(4)
A large scale epidemiological survey of sleep habits, specifically for insomnia, was conducted using 6277 new outpatients from 11 general hospitals in Japan. They were requested to answer a questionnaire newly designed for this study, which consisted