Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Shinae Kizaka-Kondoh"'
Autor:
Ning Lin, Kotaro Miyamoto, Takumi Ogawara, Saki Sakurai, Shinae Kizaka-Kondoh, Tetsuya Kadonosono
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Epitope binning, an approach for grouping antibodies based on epitope similarities, is a critical step in antibody drug discovery. However, conventional methods are complex, involving individual antibody production. Here, we established Epit
Externí odkaz:
https://doaj.org/article/854769774f9d4204bdcd2751f110b4d8
Autor:
Misa Minegishi, Takahiro Kuchimaru, Kaori Nishikawa, Takayuki Isagawa, Satoshi Iwano, Kei Iida, Hiromasa Hara, Shizuka Miura, Marika Sato, Shigeaki Watanabe, Akifumi Shiomi, Yo Mabuchi, Hiroshi Hamana, Hiroyuki Kishi, Tatsuyuki Sato, Daigo Sawaki, Shigeru Sato, Yutaka Hanazono, Atsushi Suzuki, Takahide Kohro, Tetsuya Kadonosono, Tomomi Shimogori, Atsushi Miyawaki, Norihiko Takeda, Hirofumi Shintaku, Shinae Kizaka-Kondoh, Satoshi Nishimura
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Cancer cells inevitably interact with neighboring host tissue-resident cells during the process of metastatic colonization, establishing a metastatic niche to fuel their survival, growth, and invasion. However, the underlying mechanisms in t
Externí odkaz:
https://doaj.org/article/c373ff5e397541ef903bbdc92c8afb6e
Autor:
Ryuichiro Hirano, Koki Okamoto, Miyu Shinke, Marika Sato, Shigeaki Watanabe, Hitomi Watanabe, Gen Kondoh, Tetsuya Kadonosono, Shinae Kizaka-Kondoh
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
The role of mammary gland tissue-resident macrophages (MGTRMs) in the development of TNBC breast tumors and recurrence after surgery and chemotherapy is investigated.
Externí odkaz:
https://doaj.org/article/d54fb73de5ad471e8c6fde0df3484d37
Autor:
Tetsuya Kadonosono, Kotaro Miyamoto, Shiori Sakai, Yoshiyuki Matsuo, Shojiro Kitajima, Qiannan Wang, Minori Endo, Mizuho Niibori, Takahiro Kuchimaru, Tomoyoshi Soga, Kiichi Hirota, Shinae Kizaka-Kondoh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Cancer recurrence due to tumor cell quiescence after therapy and long-term remission is associated with cancer-related death. Previous studies have used cell models that are unable to return to a proliferative state; thus, the transition bet
Externí odkaz:
https://doaj.org/article/04df67d4e5dd44408996ce01414b499b
Autor:
Kyra See, Tetsuya Kadonosono, Kotaro Miyamoto, Takuya Tsubaki, Yumi Ota, Marina Katsumi, Sumoe Ryo, Kazuki Aida, Misa Minegishi, Tatsuhiro Isozaki, Takahiro Kuchimaru, Shinae Kizaka-Kondoh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Small antibody mimetics that contain high-affinity target-binding peptides can be lower cost alternatives to monoclonal antibodies (mAbs). We have recently developed a method to create small antibody mimetics called FLuctuation-regulated Aff
Externí odkaz:
https://doaj.org/article/4a3de7440c4544338c3384a1404a0c94
Autor:
Takahiro Kuchimaru, Naoya Kataoka, Kenji Nakagawa, Tatsuhiro Isozaki, Hitomi Miyabara, Misa Minegishi, Tetsuya Kadonosono, Shinae Kizaka-Kondoh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Reliably modelling bone metastasis in mice is essential for research. Here, the authors present a new murine model for cancer metastasis based on intra-caudal artery injection that reliably recapitulates bone metastasis.
Externí odkaz:
https://doaj.org/article/e3ae7bb3f6f9431b811c5b6fa87b75ef
Autor:
Takahiro Kuchimaru, Satoshi Iwano, Masahiro Kiyama, Shun Mitsumata, Tetsuya Kadonosono, Haruki Niwa, Shojiro Maki, Shinae Kizaka-Kondoh
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
D-luciferin is the standard bioluminescent substrate for in vitro and in vivo imaging. Here the authors introduce AkaLumine-HCl, a soluble luciferin analogue with a near-infrared emission maximum, which allows deep tissue imaging at lower concentrati
Externí odkaz:
https://doaj.org/article/7c43d0c3cba6406684f84f686df358a9
Publikováno v:
Micromachines, Vol 11, Iss 5, p 480 (2020)
Microfluidic devices utilizing spheroids play important roles in in vitro experimental systems to closely simulate morphological and biochemical characteristics of the in vivo tumor microenvironment. For the observation and analysis of the inner stru
Externí odkaz:
https://doaj.org/article/d6c7886700b54d12be68af1329f30102
Publikováno v:
Micromachines, Vol 6, Iss 4, Pp 409-422 (2015)
The uniform dispersion of cells in a microchamber is important to reproduce results in cellular research. However, achieving this is difficult owing to the laminar flow caused by the small dimensions of such a chamber. In this study, we propose a tec
Externí odkaz:
https://doaj.org/article/9a21266fcd3f45f49491b9b51391c8fe
Autor:
Tadashi Ishida, Takuya Shimamoto, Maho Kaminaga, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Toru Omata
Publikováno v:
Micromachines, Vol 10, Iss 2, p 116 (2019)
The small number of high-migratory cancer cells in a cell population make studies on high-migratory cancer cells difficult. For the development of migration assays for such cancer cells, several microfluidic devices have been developed. However, they
Externí odkaz:
https://doaj.org/article/12195d416b8748e5b8684df101e7f83f