Zobrazeno 1 - 10
of 52
pro vyhledávání: '"ShinWu Jeong"'
Autor:
Maria Fernanda Suarez, Tatsuo Itakura, Satyabrata Pany, Shinwu Jeong, Shravan K. Chintala, Michael B. Raizman, Steven Riesinger, Tsvetelina Lazarova, José Echenique, Horacio M. Serra, W. Daniel Stamer, M. Elizabeth Fini
Publikováno v:
Stresses, Vol 3, Iss 3, Pp 629-652 (2023)
Elevated intraocular pressure (IOP), the major risk factor for glaucoma, is caused by decreased outflow through the trabecular meshwork (TM). The pathophysiology of ocular hypertension has been linked to stress pathways, including fibrosis, calcifica
Externí odkaz:
https://doaj.org/article/d7b8cb97eb0046e480769cd972be43a1
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253915 (2021)
Matrix metalloproteinases (MMPs) are involved in the pathology of numerous inflammatory retinal degenerations, including retinitis pigmentosa (RP). Our previous work revealed that intravitreal injections with tissue inhibitor of metalloproteinases 1
Externí odkaz:
https://doaj.org/article/99d7b495c2594c8f841169a217edb3f2
Autor:
Andrew Webster, Shravan K Chintala, Jasmine Kim, Michelle Ngan, Tatsuo Itakura, Noorjahan Panjwani, Pablo Argüeso, Joseph T Barr, Shinwu Jeong, M Elizabeth Fini
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204288 (2018)
Water soluble "vital" dyes are commonly used clinically to evaluate health of the ocular surface; however, staining mechanisms remain poorly understood. Recent evidence suggests that sublethal damage stimulates vital dye uptake by individual living c
Externí odkaz:
https://doaj.org/article/bd50d6f17f2341efb6b31a56250f4033
Autor:
Nitin Patel, Tatsuo Itakura, Shinwu Jeong, Chun-Peng Liao, Pradip Roy-Burman, Ebrahim Zandi, Susan Groshen, Jacek Pinski, Gerhard A Coetzee, Mitchell E Gross, M Elizabeth Fini
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117758 (2015)
Prostate cancer (PCa) is the second-leading cause of cancer-related mortality, after lung cancer, in men from developed countries. In its early stages, primary tumor growth is dependent on androgens, thus generally can be controlled by androgen depri
Externí odkaz:
https://doaj.org/article/ffbac6972cdd427fb5688afa9e5b89dc
Autor:
Aditi Bauskar, Wendy J Mack, Jerome Mauris, Pablo Argüeso, Martin Heur, Barbara A Nagel, Grant R Kolar, Martin E Gleave, Takahiro Nakamura, Shigeru Kinoshita, Janet Moradian-Oldak, Noorjahan Panjwani, Stephen C Pflugfelder, Mark R Wilson, M Elizabeth Fini, Shinwu Jeong
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138958 (2015)
Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout the body. CLU levels are redu
Externí odkaz:
https://doaj.org/article/3122b1b0557c4829993a05a07f8b26ae
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001286 (2011)
How epigenetic information is propagated during somatic cell divisions is still unclear but is absolutely critical for preserving gene expression patterns and cellular identity. Here we show an unanticipated mechanism for inheritance of DNA methylati
Externí odkaz:
https://doaj.org/article/91299b2a88bf4e59b6f6eae606cccf2d
Publikováno v:
PLoS Genetics, Vol 2, Iss 9, p e160 (2006)
Chromatin organization and transcriptional regulation are interrelated processes. A shortcoming of current experimental approaches to these complex events is the lack of methods that can capture the activation process on single promoters. We have rec
Externí odkaz:
https://doaj.org/article/8d295a4754b548c9934be4614f57f999
Publikováno v:
Prog Retin Eye Res
Proteostasis refers to all the processes that maintain the correct expression level, location, folding and turnover of proteins, essential to organismal survival. Both inside cells and in body fluids, molecular chaperones play key roles in maintainin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad2e82f04d6f4342ade1d0c018566c0
https://europepmc.org/articles/PMC9184305/
https://europepmc.org/articles/PMC9184305/
Autor:
Shravan K. Chintala, Jinhong Pan, Sandeep Satapathy, Rebecca Condruti, Zixuan Hao, Pei-wen Liu, Christian F. O’Conner, Joseph T. Barr, Mark R. Wilson, Shinwu Jeong, M. Elizabeth Fini
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 981
There is a significant unmet need for therapeutics to treat ocular surface barrier damage, also called epitheliopathy, due to dry eye and related diseases. We recently reported that the natural tear glycoprotein CLU (clusterin), a molecular chaperone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fec1c08ac84fcff0805ad046c9b503
https://doi.org/10.3390/ijms24020981
https://doi.org/10.3390/ijms24020981
Autor:
Jose M. Gonzalez, Ted S. Acott, W. Daniel Stamer, James C. Tan, Shravan K. Chintala, Tatsuo Itakura, Yuchen Wang, Andrew Webster, Cheryl M. Craft, M. Elizabeth Fini, Shinwu Jeong, Janice A. Vranka, Kirill A. Martemyanov, Maria Sibug Saber
Publikováno v:
J Ocul Pharmacol Ther
Purpose: GPR158 is a newly characterized family C G-protein-coupled receptor, previously identified in functional screens linked with biological stress, including one for susceptibility to ocular hypertension/glaucoma induced by glucocorticoid stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954c7801002d2c3084e30bb7f6bd3b09
https://doi.org/10.1089/jop.2018.0135
https://doi.org/10.1089/jop.2018.0135