Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Shin-ya Saito"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 142, Iss , Pp 111989- (2021)
Background and aims: Liver inflammation leads to the activation of hepatic stellate cells (HSCs), resulting in the development of liver fibrosis. The present study aimed to investigate the effects of prostaglandin E2 (PGE2), which is biosynthesized b
Externí odkaz:
https://doaj.org/article/d1899e2163294fd88a551f29cddccf74
Autor:
Naoki Dohi, Momoka Yamaguchi, Reina Hase, Ryosuke Suzuki, Yumeto Wakabayashi, Ryota Nishiyama, Shin-Ya Saito, Tomohisa Ishikawa
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255656 (2021)
Although quiescent hepatic stellate cells (HSCs) have been suggested to regulate hepatic blood flow, there is no direct evidence that quiescent HSCs display contractile abilities. Here, we developed a new method to quantitatively measure the contract
Externí odkaz:
https://doaj.org/article/253e4b840554416e9c0b451e52aa0110
Publikováno v:
Journal of Pharmacological Sciences, Vol 95, Iss 1, Pp 41-46 (2004)
Acute effect of Mao-Bushi-Saishin-To (Ma-Huang-Fu-Zi-Xi-Xin-Tang in Chinese: MBS) on histamine release was investigated. The IgE-mediated anaphylaxic response in Wistar rats was significantly suppressed by MBS and Mao. However, Saishin and Bushi had
Externí odkaz:
https://doaj.org/article/136ce258bdcc4ea68b23e4bc9d0e571f
Publikováno v:
Biological and Pharmaceutical Bulletin. 46:399-403
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b7e1fb21293b9f8675544a2571fc83c
https://doi.org/10.1248/bpb.b22-00603
https://doi.org/10.1248/bpb.b22-00603
Autor:
Momoka Yamaguchi, Saya Ohbayashi, Akira Ooka, Hinako Yamashita, Nanami Motohashi, Yukiko K. Kaneko, Toshihide Kimura, Shin-ya Saito, Tomohisa Ishikawa
Publikováno v:
Biochemical and biophysical research communications. 600
Liver fibrosis is a major consequence of chronic liver disease, where excess extracellular matrix is deposited, due caused by the activation of hepatic stellate cells (HSCs). The suppression of collagen production in HSCs is therefore regarded as a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9b33cdecf22ffd3f1c9a3c01fe6529
https://pubmed.ncbi.nlm.nih.gov/35219102
https://pubmed.ncbi.nlm.nih.gov/35219102
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 142
Liver inflammation leads to the activation of hepatic stellate cells (HSCs), resulting in the development of liver fibrosis. The present study aimed to investigate the effects of prostaglandin EHSCs isolated from mice were activated by culturing in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df95a45cb914ea3bb248b248ada88dba
https://pubmed.ncbi.nlm.nih.gov/34388524
https://pubmed.ncbi.nlm.nih.gov/34388524
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:1741-1745
Our previous studies have shown that phenylephrine-induced contraction of cutaneous arteries is primarily mediated via α1A-adrenoceptors, but not α1D-adrenoceptors that generally mediate vascular contraction, and that the larger part of the contrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17f1ae810bdb88b592945193a0a0fa59
https://doi.org/10.1248/bpb.b19-00473
https://doi.org/10.1248/bpb.b19-00473
Publikováno v:
European Journal of Pharmacology. 838:120-128
Cutaneous arteries show enhanced contraction in response to cooling, which is suggested to be mediated via α2C-adrenoceptors. We have previously shown that α1-adrenoceptors are also involved in the enhanced contraction in cooling conditions. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a31843ce03223bd1e551e331311fbe56
https://doi.org/10.1016/j.ejphar.2018.09.004
https://doi.org/10.1016/j.ejphar.2018.09.004
Publikováno v:
European Journal of Pharmacology. 826:9-16
Our previous studies have shown that α1-adrenoceptors, in addition to α2-adrenoceptors, are involved in enhanced contraction of cutaneous blood vessels during cooling. The present study aimed to elucidate the mechanism underlying it. In tail and il
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b17186bfca75890cee6235a07fab2e
https://doi.org/10.1016/j.ejphar.2018.02.023
https://doi.org/10.1016/j.ejphar.2018.02.023
Autor:
Shin-ya Saito, Momoka Yamaguchi, Takuma Furukawa, John Shannonhouse, Hirotake Ishida, Tomohisa Ishikawa, Yu Shin Kim
Publikováno v:
Eur J Pharmacol
Reduced skin blood flow has been reported in neuropathic pain patients as well as various peripheral neuropathic pain model animals. We have previously shown that vasodilators, which improves reduced skin blood flow, correlatively alleviate neuropath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd130c532793c6bbdbc1914797dd5f27
https://doi.org/10.1016/j.ejphar.2021.174448
https://doi.org/10.1016/j.ejphar.2021.174448