Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shin-itsu Kuwabe"'
Publikováno v:
Organic Process Research & Development. 13:933-935
The alcohol 2, a key intermediate in the synthesis of the highly selective EP4-receptor agonist ONO-4819, was synthesized by (R)-methyloxazaborolidine ((R)-Me-CBS)-catalyzed asymmetric reduction of...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a6c2e5b0597de7dd3c6b715c9255e9
https://doi.org/10.1021/op900118n
https://doi.org/10.1021/op900118n
Publikováno v:
Tetrahedron: Asymmetry. 7:3371-3390
The stereoselective syntheses of the C10-C22 fragment 2a and its C15-epimer 2b of the immunosuppressant FK 506 1 have been carried out through convergent coupling of the sulfone 3 , which could be constructed by highly stereocontrolled ester-enolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10731bc56a4d0d9bd2c15514d059e499
https://doi.org/10.1016/s0957-4166(96)00445-4
https://doi.org/10.1016/s0957-4166(96)00445-4
Publikováno v:
ChemInform. 28
The stereoselective syntheses of the C10-C22 fragment 2a and its C15-epimer 2b of the immunosuppressant FK 506 1 have been carried out through convergent coupling of the sulfone 3 , which could be constructed by highly stereocontrolled ester-enolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16dca6a42b835ef232be274c515b5946
https://doi.org/10.1002/chin.199714214
https://doi.org/10.1002/chin.199714214
Publikováno v:
Tetrahedron Letters. 32:2909-2912
An ene-ester 5 prepared from L-malic acid was subjected to the ester-enolate Claisen rearrangement under Ireland's condition to give stereoselectively C16–C22 fragment 11 containing ( E ) trisubstituted double bond which was further advanced to C1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83f412c09a68753a96c4536ae12836cb
https://doi.org/10.1016/0040-4039(91)80646-n
https://doi.org/10.1016/0040-4039(91)80646-n
Autor:
Masanori Kawamura, Yoshiyuki Shinagawa, Takayuki Maruyama, Kigen Kondo, Hisao Nakai, Shinsuke Hashimoto, Masaaki Toda, Kiyoto Sakata, Toru Maruyama, Yasufumi Kawanaka, Yoko Kishida, Shin-itsu Kuwabe, Tai Shiraishi, Shuichi Ohuchida, Hideyuki Yoshida, Akiteru Seki
Publikováno v:
Bioorganicmedicinal chemistry. 10(7)
A practical method of synthesizing a highly selective EP4-receptor agonist 1 using Corey lactone 2 as a key intermediate was developed. Selective methanesulfonylation of the primary alcohol of the diol 8 under the newly devised conditions followed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a49236eb86a2d0ba0a371eed53f4f2
https://pubmed.ncbi.nlm.nih.gov/11983506
https://pubmed.ncbi.nlm.nih.gov/11983506
Publikováno v:
Journal of the American Chemical Society. 122:12907-12908
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82876a1e93778ec1862d4898b929352a
https://doi.org/10.1021/ja005698v
https://doi.org/10.1021/ja005698v
Autor:
Tai Shiraishi, Yasufumi Kawanaka, Ikuo Shinohara, Takayuki Makihara, Shigeru Sakuyama, Shuichi Ohuchida, Chisa Ohta, Hiroshi Araki, Shin-itsu Kuwabe, Takuya Seko
Publikováno v:
The Journal of Organic Chemistry. 75:1330-1330
An improved synthesis of the highly selective EP4-receptor agonist ONO-4819 has been developed. The previous synthesis suffered from several drawbacks, in which a critical one is the difficulty in the removal of byproducts leading to unsatisfactory q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619fe7fc3fb75d3e11b8d773e19bab96
https://doi.org/10.1021/jo902446x
https://doi.org/10.1021/jo902446x