Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Shin-ichiro Honda"'
Autor:
Kaori Ota, Jian-Rong Zhou, Kazumi Yokomizo, Tomohiro Kozako, Shin-ichiro Honda, Nobuhiro Kashige, Makoto Furutachi, Kunihiro Sumoto
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100559- (2022)
Homodimers that deployed boronic acids and their esters in their termini, namely boronic acid derivative homodimers, were designed. The boronic acid pinacol ester homodimer displayed antiviral activity and the boronic acid homodimer, in contrast, exe
Externí odkaz:
https://doaj.org/article/928eb1bab9ef42b4b0d8fdd2018a5cdf
Autor:
Shin-ichiro Honda, Nobuhiro Harada
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
An important function of aromatase in the brain is conversion of testosterone secreted from the testis into estradiol. Estradiol produced in the brain is thought to be deeply involved in the formation of sexually dimorphic nuclei and sexual behavior
Externí odkaz:
https://doaj.org/article/cbfab2f2a11f402c95ccc58bdd25dbd1
Autor:
Tomohiro Kozako, Paolo Mellini, Takeo Ohsugi, Akiyoshi Aikawa, Yu-ichiro Uchida, Shin-ichiro Honda, Takayoshi Suzuki
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases
Externí odkaz:
https://doaj.org/article/d44410c5de754805a609bcde9631a189
Autor:
Shin-ichiro Honda, Kazuki Sato, Naoya Totsuka, Satoshi Fujiyama, Manabu Fujimoto, Kensuke Miyake, Chigusa Nakahashi-Oda, Satoko Tahara-Hanaoka, Kazuko Shibuya, Akira Shibuya
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Marginal zone B cells are mostly characterized in the context of host defense against bacterial blood-borne pathogens. Here the authors show that TLR4 signaling in these cells requires Fcα/μR (CD351) and that they are a major source of IL-6 in a mo
Externí odkaz:
https://doaj.org/article/56c8baf3ce2c4f159fbd3742c478ed1d
Autor:
Tomohiro Kozako, Takayoshi Suzuki, Makoto Yoshimitsu, Naomichi Arima, Shin-ichiro Honda, Shinji Soeda
Publikováno v:
Molecules, Vol 19, Iss 12, Pp 20295-20313 (2014)
Sirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are seven isoforms (SIRT1–7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders. Numerous studies ha
Externí odkaz:
https://doaj.org/article/dd6bd9367c58441caced04510d0db9ec
Autor:
Satoko Arai, Natsumi Maehara, Yoshihiro Iwamura, Shin-ichiro Honda, Katsuhiko Nakashima, Toshihiro Kai, Masato Ogishi, Kumiko Morita, Jun Kurokawa, Mayumi Mori, Yuji Motoi, Kensuke Miyake, Nobuyuki Matsuhashi, Ken-ichi Yamamura, Osamu Ohara, Akira Shibuya, Edward K. Wakeland, Quan-Zhen Li, Toru Miyazaki
Publikováno v:
Cell Reports, Vol 3, Iss 4, Pp 1187-1198 (2013)
Natural immunoglobulin M (IgM) is reactive to autoantigens and is believed to be important for autoimmunity. Blood pentameric IgM loaded with antigens forms a large immune complex (IC) that contains various elements, including apoptosis inhibitor of
Externí odkaz:
https://doaj.org/article/1bc8cafffd524d5dbd5de39398e981e7
Autor:
Tomohiro Kozako, Naho Kato, Takeo Ohsugi, Yu‐ichiro Uchida, Makoto Yoshimitsu, Kenji Ishitsuka, Yasuki Higaki, Haruna Sato, Akiyoshi Aikawa, Shin‐ichiro Honda
Publikováno v:
The FEBS Journal. 289:3477-3488
Adult T-cell leukemia/lymphoma (ATL) develops after a long period of human T-cell leukemia virus (HTLV)-1 infection and is associated with host aging in addition to genetic abnormalities in HTLV-1 infected cells. SIRT1 is a histone deacetylase involv
Author response for 'SRT1720 induces SIRT1‐independent cell death in adult T‐cell leukemia/lymphoma'
Autor:
null Tomohiro Kozako, null Naho Kato, null Takeo Ohsugi, null Yu‐ichiro Uchida, null Makoto Yoshimitsu, null Kenji Ishitsuka, null Yasuki Higaki, null Haruna Sato, null Akiyoshi Aikawa, null Shin‐ichiro Honda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a82d04c0130e5361be3f0ce6cf6add1c
https://doi.org/10.1111/febs.16353/v2/response1
https://doi.org/10.1111/febs.16353/v2/response1
Publikováno v:
Approaching Complex Diseases ISBN: 9783030328566
Epigenetics is defined as heritable alterations in gene expression that are not caused by changes in DNA sequence. Such normal alterations are vital for appropriate differentiation and development. However, unfavorable epigenetic alterations are usua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e13c3bd703aa9110e55b1be599d2a36a
https://doi.org/10.1007/978-3-030-32857-3_6
https://doi.org/10.1007/978-3-030-32857-3_6
Autor:
Shin-ichiro Honda, Akiyoshi Aikawa, Takeo Ohsugi, Yuichiro Uchida, Takayoshi Suzuki, Tomohiro Kozako, Paolo Mellini
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
BMC Cancer
BMC Cancer
Background Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute