Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shin-ichi Yoshikubo"'
Autor:
Takafumi Takai, Yasutaka Hoashi, Yohei Kosugi, Masaharu Nakayama, Osamu Uchikawa, Shin-ichi Yoshikubo, Masato Nakashima, Tatsuki Koike, Keisuke Hirai
Publikováno v:
Journal of Medicinal Chemistry. 54:4207-4218
Novel tricyclic dihydrofuran derivatives were designed, synthesized, and evaluated as melatonin receptor (MT(1)/MT(2)) ligands based on the previously reported 1,6-dihydro-2H-indeno[5,4-b]furan 1a. By screening the central tricyclic cores, we identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86056c17d6013d1bd01a7dbcf30e5296
https://doi.org/10.1021/jm200385u
https://doi.org/10.1021/jm200385u
Autor:
Tetsuya Sasabe, Tohru Sawada, Masaki Takeda, Masayuki Kobayashi, Hirotaka Onoe, Yusuke Kondo, Kazuyuki Imamura, Yasuyoshi Watanabe, Shin-ichi Yoshikubo
Publikováno v:
European Journal of Neuroscience. 16:975-980
Functional imaging technique using positron emission tomography (PET) has made it possible to localize functional brain regions in the human brain by detecting changes in regional cerebral blood flow (rCBF). Performing PET studies in the monkey will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87b88be9b7e51569e331e956a068a98b
https://doi.org/10.1046/j.1460-9568.2002.02151.x
https://doi.org/10.1046/j.1460-9568.2002.02151.x
Autor:
Yoshihide Tomata, Mariko Hirozane, Jun Kunitomo, Shin-ichi Yoshikubo, Tatsuhiko Fujimoto, Keisuke Hirai, Keiji Nishiyama, Masato Nakashima, Shogo Marui
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
During our efforts to identify a series of potent, selective, orally active human Orexin-2 Receptor (OX2R) antagonists, we elucidated structure-activity relationship (SAR) on the 7-position of a benzoxazepine scaffold by utilizing Hammett σp and Han
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a524aafca299ff378c32ce7689d73389
https://pubmed.ncbi.nlm.nih.gov/21917455
https://pubmed.ncbi.nlm.nih.gov/21917455
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 330(3)
Melatonin receptor agonists such as melatonin and ramelteon [(S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl]-propionamide; TAK-375] have sleep-promoting effects in humans. In preclinical models, these effects are more similar to those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d415b58583469a02d5a56a1ad5093a55
https://pubmed.ncbi.nlm.nih.gov/19556449
https://pubmed.ncbi.nlm.nih.gov/19556449
Autor:
Shin-ichi Yoshikubo, Hisao Nishikawa, Shigenori Ohkawa, Nobuhito Yukuhiro, Masaomi Miyamoto, Hiroyuki Kimura
Publikováno v:
Brain research. 1027(1-2)
We investigated the effects of (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4]furan-8-yl)ethyl]propionamide (ramelteon, TAK-375), a novel MT1/MT2 receptor agonist, on nocturnal sleep in freely moving monkeys and compared these results with those of mela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e6e9f200a8560c8eb5ac9e318b19e2
https://pubmed.ncbi.nlm.nih.gov/15494157
https://pubmed.ncbi.nlm.nih.gov/15494157
Autor:
Masayuki, Kobayashi, Tetsuya, Sasabe, Masaki, Takeda, Yusuke, Kondo, Shin-Ichi, Yoshikubo, Kazuyuki, Imamura, Hirotaka, Onoe, Tohru, Sawada, Yasuyoshi, Watanabe
Publikováno v:
The European journal of neuroscience. 16(5)
Functional imaging technique using positron emission tomography (PET) has made it possible to localize functional brain regions in the human brain by detecting changes in regional cerebral blood flow (rCBF). Performing PET studies in the monkey will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3af371babea6d677a5f28cd9d7db09a5
https://pubmed.ncbi.nlm.nih.gov/12372035
https://pubmed.ncbi.nlm.nih.gov/12372035
Autor:
Shin-ichi Yoshikubo, Yasuo Nagai, Kohji Fukatsu, Shigenori Ohkawa, Naohisa Fukuda, Takahiro Nakayama, Tadatoshi Hashimoto
Publikováno v:
Japanese Journal of Pharmacology. 71:172
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::768ab78b0858c3f85d572960e9318591
https://doi.org/10.1016/s0021-5198(19)36929-x
https://doi.org/10.1016/s0021-5198(19)36929-x