Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Shin-ichi Mihara"'
Autor:
Masafumi Fujimoto, Ken-ichi Matsumura, Shin-ichi Mihara, Natsuki Ishizuka, Katsunori Sakai, Teruo Yamamori
Publikováno v:
Journal of Medicinal Chemistry. 45:2041-2055
A novel series of endothelin-A (ETA) selective receptor antagonists having a 2H-chromene skeleton are described. A lead compound, 2-(benzo[1,3]dioxol-5-yl)-2H-chromene-3-carboxylic acid (3), was found by modifications of our own angiotensin II antago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d19e99d38afac7ea8470e8e09a1d6d53
https://doi.org/10.1021/jm010382z
https://doi.org/10.1021/jm010382z
Autor:
Yoko Hayasaki-Kajiwara, Mitsuyoshi Ninomiya, Toshitake Shimamura, Takanori Iwasaki, Masatoshi Nakajima, Shin-ichi Mihara, Masafumi Fujimoto, Noriyuki Naya, Masao Masui, Masaru Kawakami
Publikováno v:
Journal of Cardiovascular Pharmacology. 37:471-482
The pharmacologic properties of a novel nonpeptide endothelin (ET) receptor antagonist, S-1255 ([R]-[+]-2-[benzo(1,3)dioxol-5-yl]-6-isopropyl-4-[4-methoxyphenyl]-2H-chromene-3-carboxylic acid), was studied. [3H]S-1255 specifically bound to porcine ao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e99b18d0ae7f35b76c7e845732fd41f
https://doi.org/10.1097/00005344-200104000-00014
https://doi.org/10.1097/00005344-200104000-00014
Autor:
Yasuhiko Kanda, Toshiro Konoike, Yoshitaka Araki, Shin-ichi Mihara, Masafumi Fujimoto, Tadashi Takahashi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1875-1878
The synthesis and structure–activity relationships of a series of sulfonamide endothelin antagonists are described. In the course of our modification studies, we discovered ET B selective antagonists. The most potent compound 15f displays IC 50 val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5399682ad71ee1ffa2708687046a08bd
https://doi.org/10.1016/s0960-894x(00)00366-8
https://doi.org/10.1016/s0960-894x(00)00366-8
Publikováno v:
European Journal of Pharmacology. 345:339-342
We examined the affinity of endothelin-1, endothelin-3 and four endothelin receptor ligands, BQ788 (cis-2,6-dimethylpiperidinocarbonyl-gamma-methyl-Leu-D-Trp(1-CO 2CH3-D-Nle-ONa), SB-209670 ((+)-(1S,2R,3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08eb927cafc5937198855174380b7104
https://doi.org/10.1016/s0014-2999(98)00016-8
https://doi.org/10.1016/s0014-2999(98)00016-8
Publikováno v:
European Journal of Pharmacology. 342:319-324
S-0139 (27-O-3-[2-(3-carboxy-acryloylamino)-5-hydroxyphenyl]-acryloyloxy myricerone, sodium salt) is a highly specific nonpeptide endothelin ETA receptor antagonist. The binding of [ 3 H ]S-0139 was compared to that of [ 125 I ]endothelin-1 to charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3670ef69ae3b186e0cbdcd9e6ae0e7ce
https://doi.org/10.1016/s0014-2999(97)01479-9
https://doi.org/10.1016/s0014-2999(97)01479-9
Autor:
Yukio Takahara, Osamu Uno, Susumu Funakawa, Masao Masui, Kazuki Matsunaga, Shin-ichi Mihara, Kazumi Iwaki
Publikováno v:
Journal of Cardiovascular Pharmacology. 28:526-532
S-2150 is a new 1,5-benzothiazepine derivative that inhibits [ 3 H]diltiazem and [ 3 H]WB4101 bindings to the membrane of rat tissue. The effects of S-2150 on ischemia/reperfusion injury were studied in anesthetized rats. S-2150 reduced the myocardia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bfeddcb3b505caf64cc9c296b3d086
https://doi.org/10.1097/00005344-199610000-00008
https://doi.org/10.1097/00005344-199610000-00008
Autor:
Junko Kikuchi, Yuji Ikenishi, Yoshihiro Terui, Kensuke Sakurawi, Kazuhiro Takahashi, Toshiro Konoike, Takehiko Tozyo, Tomohiro Sato, Shin-ichi Mihara, Miharu Nakamura, Fumio Yasuda, Masafumi Fujimoto, Tsuyoshi Iwata
Publikováno v:
ChemInform. 27
As the first non-peptide endothelin receptor antagonist form a higher plant, a new triter penoid, myiceric acid A (50-235) (1) was isolated from the bayberry, Myrica cerifera. myriceric acid A (1) inhibited not only an endothelin-1-induced increase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a93b918cd860d87273817ef7c0b2594
https://doi.org/10.1002/chin.199633208
https://doi.org/10.1002/chin.199633208
Autor:
Masafumi Fujimoto, Toshiro Konoike, Shin-ichi Mihara, Yoshitaka Araki, Yasuhiko Kanda, Tadashi Takahashi
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1d7fd4b2fed81a59986bd738c1e45c3
https://doi.org/10.1002/chin.200046153
https://doi.org/10.1002/chin.200046153
Autor:
Miharu Nakamura, Shigeyuki Nakajima, Shin-ichi Mihara, Motohiko Ueda, Masafumi Fujimoto, Kensuke Sakurai
Publikováno v:
FEBS Letters. 305:41-44
A potent non-peptide ET receptor antagonist, myrireron caffeoyl ester (50–235), was isolated from the bayberry, Myrica cerifera. This compound selectively antagonized specific binding of [125I]ET-1, but not of [125I]ET-3, to rat cardiac membranes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff869f007681b72e9fe6df515543456
https://doi.org/10.1016/0014-5793(92)80651-v
https://doi.org/10.1016/0014-5793(92)80651-v
Publikováno v:
European Journal of Pharmacology. 215:259-264
A single class of [ 125 I]angiotensin II ([ 125 I]AII) binding sites was found in porcine aortic smooth muscle membranes. Des-Asp 1 -AII (AIII) and des-Asp 1 -[Ile 8 ]AII were 20 times less potent than AII or [Sar 1 ,Ile 8 ]AII to displace [ 125 I]AI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a6c58e06a17ca5dc02593f862d3434
https://doi.org/10.1016/0014-2999(92)90036-4
https://doi.org/10.1016/0014-2999(92)90036-4