Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Shin-ichi Ikeda"'
Autor:
Junhan Chen, Shin-ichi Ikeda, Yajing Yang, Yan Zhang, Ziyan Ma, Yifan Liang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-11 (2024)
Abstract Background Scleral extracellular matrix (ECM) remodeling plays a crucial role in the development of myopia, particularly in ocular axial elongation. Thrombospondin-1 (THBS1), also known as TSP-1, is a significant cellular protein involved in
Externí odkaz:
https://doaj.org/article/6b75a6c68fa941398a761aa987ca8b26
Publikováno v:
Eng, Vol 4, Iss 4, Pp 2991-3006 (2023)
Hoof and leg problems in racehorses can cause serious injuries and decrease their value. Although therapeutic shoeing using special horseshoes can increase the effectiveness of veterinary care, it is labor-intensive and burdensome for farriers. A thr
Externí odkaz:
https://doaj.org/article/ddb7ed20c27642db92ddf7cdc93409a3
Autor:
Longdan Kang, Shin-ichi Ikeda, Yajing Yang, Heonuk Jeong, Junhan Chen, Yan Zhang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
Publikováno v:
Eye and Vision, Vol 10, Iss 1, Pp 1-11 (2023)
Abstract Background Recent studies have indicated a strong correlation between endoplasmic reticulum (ER) stress and myopia and that eyedrops containing the ER stress inducer tunicamycin (Tm) can induce myopic changes in C57BL/6 J mice. Therefore, th
Externí odkaz:
https://doaj.org/article/40cbfeb584774b5fad485b9437d35174
Autor:
Jing Hou, Kiwako Mori, Shin-ichi Ikeda, Heonuk Jeong, Hidemasa Torii, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Myopia is becoming more common across the world, necessitating the development of preventive methods. We investigated the activity of early growth response 1 (EGR-1) protein and discovered that Ginkgo biloba extracts (GBEs) activated EGR-1 i
Externí odkaz:
https://doaj.org/article/81573a02425740afbdca280adc8df774
Autor:
Junhan Chen, Shin-ichi Ikeda, Longdan Kang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundOcular axial elongation is one of the features of myopia progression. Endoplasmic reticulum (ER) stress-associated scleral remodeling plays an important role in ocular axial elongation. Bisphenol A (BPA) is one of the most common environmen
Externí odkaz:
https://doaj.org/article/5c39c899d1f24818a2bd0cad30505c39
Autor:
Shin-ichi Ikeda, Toshihide Kurihara, Xiaoyan Jiang, Yukihiro Miwa, Deokho Lee, Naho Serizawa, Heonuk Jeong, Kiwako Mori, Yusaku Katada, Hiromitsu Kunimi, Nobuhiro Ozawa, Chiho Shoda, Mari Ibuki, Kazuno Negishi, Hidemasa Torii, Kazuo Tsubota
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
he underlying mechanism of myopic axial elongation of the eyes has long been unknown. Here, the authors show that endoplasmic reticulum stress in the sclera and its sensor proteins, PERK and ATF6, are involved in myopic axial elongation
Externí odkaz:
https://doaj.org/article/abe2d08ccb054189bebfa5d5b0ad66d5
Autor:
Saori Kakehi, Yoshifumi Tamura, Shin-ichi Ikeda, Naoko Kaga, Hikari Taka, Yuya Nishida, Ryuzo Kawamori, Hirotaka Watada
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Inactivity causes insulin resistance in skeletal muscle and exacerbates various lifestyle-related diseases. We previously found that 24-h hindlimb cast immobilization (HCI) of the predominantly slow-twitch soleus muscle increased intramyocellular dia
Externí odkaz:
https://doaj.org/article/679f5dd1cbf64525a1e88f561ea72b20
Autor:
Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor
Externí odkaz:
https://doaj.org/article/ae1dd53d987140b484aa532c90409781
Autor:
Shin-ichi Ikeda, Yoshifumi Tamura
Publikováno v:
Journal of Physical Fitness and Sports Medicine, Vol 2, Iss 2, Pp 233-236 (2013)
Macrophage-induced inflammation is an important pathophysiological mechanism of insulin resistance, especially in adipose tissue. It has been demonstrated that exercise has anti-inflammatory effects and enhances insulin sensitivity in skeletal muscle
Externí odkaz:
https://doaj.org/article/194820381c03418aadf9ac03b8dd56ec
Autor:
Ziyan Ma, Heonuk Jeong, Yajing Yang, Xiaoyan Jiang, Shin‐ichi Ikeda, Kazuno Negishi, Toshihide Kurihara, Kazuo Tsubota
Publikováno v:
Ophthalmic and Physiological Optics. 43:558-565
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8d3372fc0a81a3be66ed4bf1db11377
https://doi.org/10.1111/opo.13125
https://doi.org/10.1111/opo.13125