Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Shin-ichi INABA"'
Autor:
Ryotaku Inoue, Keiko Oshima, Shin-ichi Inaba, Takashi Kagari, Kaoru Tanaka-takanaka, Wataru Tomisato, Takaichi Shimozato, Takashi Izumi, Hiromi Doi-Komuro, Maki Goto, Hiroshi Yuita, Hisako Tanaka
Publikováno v:
Biopharmaceutics & Drug Disposition. 37:561-573
The pharmacokinetic (PK) and pharmacodynamic (PD) modeling was conducted for the reduction of peripheral lymphocytes after oral administration of CS-0777 to healthy rats, monkeys and experimental autoimmune encephalomyelitis (EAE) induced rats. M1, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea3f0a8b833aeadfb8346a8294affc81
https://doi.org/10.1002/bdd.2048
https://doi.org/10.1002/bdd.2048
Autor:
Kiyoaki Yonesu, Maki Yamaguchi-Goto, Takashi Izumi, Hidetaka Sakurai, Shin-ichi Inaba, Kaoru Tanaka-takanaka, Kazuishi Kubota
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(3)
1. CS-0777, a candidate compound for autoimmune diseases, becomes phosphorylated active metabolite, M1, by fructosamine 3-kinase (FN3K), FN3K-related protein (FN3K-RP); and M1 is reverted back to CS-0777 by alkaline phosphatase (ALP) in the body. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dc80f97b33868104900fe413f55344
https://pubmed.ncbi.nlm.nih.gov/28287856
https://pubmed.ncbi.nlm.nih.gov/28287856
Autor:
Ikeda Takuya, Toshiyasu Takemoto, Yukiko Sekiguchi, Takashi Kagari, Takaichi Shimozato, Takeshi Fukuda, Taiji Goto, Yumi Kawase, Tsuyoshi Nakamura, Takashi Tsuji, Futoshi Nara, Keisuke Suzuki, Takashi Izumi, Takahide Nishi, Masakazu Tamura, Tomohiro Honda, Shin-ichi Inaba, Takako Kimura, Yumiko Mizuno, Chizuko Yahara
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4246-4256
We report herein the synthesis and structure-activity relationships (SAR) of a series of benzyl ether compounds as an S1P₁ receptor modulator. From our SAR studies, the installation of substituents onto the central benzene ring of 2a was revealed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6618541f0da9c0a0ca160ca5545ee91
https://doi.org/10.1016/j.bmc.2014.05.035
https://doi.org/10.1016/j.bmc.2014.05.035
Publikováno v:
Molecular & Cellular Proteomics : MCP
Molecular identification of endogenous enzymes and biologically active substances from complex biological sources remains a challenging task, and although traditional biochemical purification is sometimes regarded as outdated, it remains one of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97067b6776a70308f917e6c7dfe84b6
http://europepmc.org/articles/PMC3734587
http://europepmc.org/articles/PMC3734587
Autor:
Shin-Ichi, Inaba, Maki, Goto, Kaoru, Tanaka-Takanaka, Hisako, Tanaka, Wataru, Tomisato, Hiroshi, Yuita, Hiromi, Doi-Komuro, Ryotaku, Inoue, Keiko, Oshima, Takashi, Kagari, Takaichi, Shimozato, Takashi, Izumi
Publikováno v:
Biopharmaceuticsdrug disposition. 37(9)
Pharmacokinetic (PK) and pharmacodynamic (PD) modeling was conducted for the reduction of peripheral lymphocytes after oral administration of CS-0777 to healthy rats, monkeys and experimental autoimmune encephalomyelitis (EAE) induced rats. The phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5eda98e35e231eaa795816d8c32c7364
https://pubmed.ncbi.nlm.nih.gov/27764535
https://pubmed.ncbi.nlm.nih.gov/27764535
Autor:
Nobuaki Watanabe, Shin-ichi Inaba, Chizuko Yahara, Kazuishi Kubota, Masakazu Tamura, Kiyoaki Yonesu, Futoshi Nara, Tomohiro Honda, Tatsuji Matsuoka
Publikováno v:
The Journal of Biological Chemistry
CS-0777 is a selective sphingosine 1-phosphate (S1P) receptor 1 modulator with potential benefits in the treatment of autoimmune diseases, including multiple sclerosis. CS-0777 is a prodrug that requires phosphorylation to an active S1P analog, simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f6c4a8e90376aa653008ffe88252e7
https://doi.org/10.1074/jbc.m110.217299
https://doi.org/10.1074/jbc.m110.217299
Autor:
Wataru Tomisato, Keisuke Suzuki, Ryotaku Inoue, Yumi Kawase, Takashi Izumi, Keiko Oshima, Hiroshi Yuita, Takaichi Shimozato, Katsuyoshi Nakajima, Takahide Nishi, Shojiro Miyazaki, Futoshi Nara, Yukiko Iio, Takashi Kagari, Shin-ichi Inaba, Takashi Ohnuki, Toshiyasu Takemoto, Hiromi Doi
Publikováno v:
ACS Medicinal Chemistry Letters. 2:368-372
CS-0777 (3) is phosphorylated in vivo, and the phosphate of CS-0777 (CS-0777-P) (4) acts as a selective S1P receptor-1 (S1P1) modulator. We report herein the synthesis of CS-0777 and CS-0777-P, pharmacological effects such as S1P1 and S1P3 agonist ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b3b35dd0b318c4a46755aa807e3542
https://doi.org/10.1021/ml100301k
https://doi.org/10.1021/ml100301k
Autor:
Hamim Zahir, Kenneth E. Truitt, James B. Moberly, Timothy J. Carrothers, Takaichi Shimozato, Shashank Rohatagi, Shin-ichi Inaba
Publikováno v:
The Journal of Clinical Pharmacology. 49:50-62
Pharmacokinetic (PK) and exposure-response modeling of a selective sphingosine 1-phosphate receptor-1 modulator (CS-0777) was conducted in an iterative process to guide early clinical development decisions. A model based on preclinical data from monk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357b476d17e56ba0df81bf6921f66594
https://doi.org/10.1177/0091270008325672
https://doi.org/10.1177/0091270008325672
Autor:
Tohru Takahashi, Akira Shinagawa, Kimihisa Ichikawa, Kazuishi Kubota, Takashi Izumi, Yumiko Fukushima, Hidetaka Sakurai, Shin-ichi Inaba, Mihoko Watanabe, Rika Nakano
Publikováno v:
Pharmacology Research & Perspectives
CS-917 (MB06322) is a selective small compound inhibitor of fructose 1,6-bisphosphatase (FBPase), which is expected to be a novel drug for the treatment of type 2 diabetes by inhibiting gluconeogenesis. CS-917 is a bisamidate prodrug and activation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f547310262854df8b4d423448df751e2
http://europepmc.org/articles/PMC4492754
http://europepmc.org/articles/PMC4492754
Autor:
Takashi Izumi, Maki Goto, Hisako Tanaka, Shin-ichi Inaba, Makoto Takahashi, Haruo Iwabuchi, Tomoko Ikeda
1. Disposition and metabolism of CS-0777 (1-{5-[(3R)-3-amino-4-hydroxy-3- methylbutyl]-1-methyl-1H-pyrrol-2-yl}-4-(4-methylphenyl) butan-1-one), a selective sphingosine 1-phosphate receptor-1 modulator under development for autoimmune conditions was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f5565753aafdc646029efaf0e4f23e
