Výsledky vyhledávání - "Shin-Ruen Yang"

Akademický článek

NSC828779 Alleviates Renal Tubulointerstitial Lesions Involving Interleukin-36 Signaling in Mice

Autor: Shin-Ruen Yang, Szu-Chun Hung, Lichieh Julie Chu, Kuo-Feng Hua, Chyou-Wei Wei, I-Lin Tsai, Chih-Chin Kao, Chih-Chien Sung, Pauling Chu, Chung-Yao Wu, Ann Chen, Alexander T. H. Wu, Feng-Cheng Liu, Hsu-Shan Huang, Shuk-Man Ka

Publikováno v: Cells, Vol 10, Iss 11, p 3060 (2021)

Renal tubulointerstitial lesions (TILs), a common pathologic hallmark of chronic kidney disease that evolves to end-stage renal disease, is characterized by progressive inflammation and pronounced fibrosis of the kidney. However, current therapeutic

Externí odkaz: https://doaj.org/article/a2306ac572bc4bf5b23db0435511be33

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Akademický článek

Accelerated and Severe Lupus Nephritis Benefits From M1, an Active Metabolite of Ginsenoside, by Regulating NLRP3 Inflammasome and T Cell Functions in Mice

Autor: Tsai-Jung Lin, Chung-Yao Wu, Pei-Yi Tsai, Wan-Han Hsu, Kuo-Feng Hua, Ching-Liang Chu, Yu-Chieh Lee, Ann Chen, Sheau-Long Lee, Yi-Jin Lin, Chih-Yu Hsieh, Shin-Ruen Yang, Feng-Cheng Liu, Shuk-Man Ka

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Chinese herbal medicines used in combination have long-term been shown to be mild remedies with “integrated effects.” However, our study provides the first demonstration that M1, an active metabolite of ginsenoside, exerted its dramatic therapeut

Externí odkaz: https://doaj.org/article/c3186bffa9224ae58d0125749ce6a98d

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LCC18 , a benzamide‐linked small molecule, ameliorates IgA nephropathy in mice

Autor: Yusuke Suzuki, Shuk-Man Ka, Chung Yao Wu, Shin Ruen Yang, Akiko Takahata, Chih Yu Hsieh, Cheng-Hsu Chen, Hsu Shan Huang, Hsiao Wen Chiu, Debabrata Mukhopadhyay, Ann Chen, Kuo Feng Hua

Publikováno v: The Journal of Pathology. 253:427-441

IgA nephropathy (IgAN), an immune complex-mediated process and the most common primary glomerulonephritis, can progress to end-stage renal disease in up to 40% of patients. Accordingly, a therapeutic strategy targeting a specific molecular pathway is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0663ccb2202b442ef06ad8387b1a21d8
https://doi.org/10.1002/path.5609

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Tris DBA ameliorates IgA nephropathy by blunting the activating signal of NLRP3 inflammasome through SIRT1‐ and SIRT3‐mediated autophagy induction

Autor: Chia Chao Wu, Yi-Shan Tsai, Shin-Ruen Yang, Jia-Feng Chang, Chiz-Tzung Chang, Shuk-Man Ka, Chih-Yu Hsieh, Shun-Min Yang, Kuo-Feng Hua, Chung-Yao Wu, Ann Chen, Jack L. Arbiser

Publikováno v: Journal of Cellular and Molecular Medicine

Tris (dibenzylideneacetone) dipalladium (Tris DBA), a small‐molecule palladium complex, can inhibit cell growth and proliferation in pancreatic cancer, lymphocytic leukaemia and multiple myeloma. Given that this compound is particularly active agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4090a1755bd4886ac9ec5d1db192561f
http://europepmc.org/articles/PMC7753881

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Tris DBA Ameliorates Accelerated and Severe Lupus Nephritis in Mice by Activating Regulatory T Cells and Autophagy and Inhibiting the NLRP3 Inflammasome

Autor: Sung-Sen Yang, Ann Chen, Ching-Liang Chu, Yu-Chuan Lin, Chung-Yao Wu, Shun-Min Yang, Feng-Cheng Liu, Shin-Ruen Yang, Shuk-Man Ka, Kuo-Feng Hua, Jack L. Arbiser

Publikováno v: The Journal of Immunology. 204:1448-1461

Tris (dibenzylideneacetone) dipalladium (Tris DBA), a small-molecule palladium complex, has been shown to inhibit cell growth and proliferation in pancreatic cancer, lymphocytic leukemia, and multiple myeloma. In the current study, we examined the th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37116a4091157cdf6b06ba1e48cbf457
https://doi.org/10.4049/jimmunol.1801610

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Cf‐02, a novel benzamide‐linked small molecule, blunts NF‐κB activation and NLRP3 inflammasome assembly and improves acute onset of accelerated and severe lupus nephritis in mice

Autor: Yu Ling Tsai, Chung Yao Wu, Hsu Shan Huang, Yu-Juei Hsu, Kuo Feng Hua, Chih Yu Yang, Chih Yu Hsieh, Jia Feng Chan, Ann Chen, Chia-Chao Wu, Chia Chung Lee, Feng Cheng Liu, Chih Jun Wan, Debabrata Mukhopadhyay, Shuk-Man Ka, Jui Chun Weng, Shin Ruen Yang

Publikováno v: FASEB J

In the present study, acute onset of severe lupus nephritis was successfully treated in mice using a new, benzamide-linked, small molecule that targets immune modulation and the NLRP3 inflammasome. Specifically, 6-(2,4-difluorophenyl)-3-(3-(trifluoro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5919f7a6023ae7ac935ca69ec70a9354
https://doi.org/10.1096/fj.202100047r

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Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-κB/NLRP3 inflammasome and sirtuin 1/autophagy axis

Autor: Ann Chen, Hsu Wan-Han, Feng-Cheng Liu, Shuk-Man Ka, Shin-Ruen Yang, Kuo-Feng Hua, Hung-Sheng Shang, Chung-Yao Wu

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(10)

Using honokiol (HNK), a major anti-inflammatory bioactive compound in Magnolia officinalis, we show a potent therapeutic outcome against an accelerated, severe form of lupus nephritis (ASLN). The latter may follow infectious insults that act as envir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101a56fd527cc7ff6c776708fbf80af9
https://pubmed.ncbi.nlm.nih.gov/32813287

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