Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Shin-Ichi Oka"'
Autor:
Chun-yang Huang, Shin-ichi Oka, Xiaoyong Xu, Chian-Feng Chen, Chien-Yi Tung, Ya-Yuan Chang, Youssef Mourad, Omair Vehra, Andreas Ivessa, Ghassan Yehia, Peter Romanienko, Chiao-Po Hsu, Junichi Sadoshima
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract PERM1 (PGC-1/ERR-induced regulator in muscle 1) is a muscle-specific protein induced by PGC-1 and ERRs. Previous studies have shown that PERM1 promotes mitochondrial biogenesis and metabolism in cardiomyocytes in vitro. However, the role of
Externí odkaz:
https://doaj.org/article/7e77c979d53d4293a3e34436456b15e9
Autor:
Narayani Nagarajan, Shin-ichi Oka, Jihoon Nah, Changgong Wu, Peiyong Zhai, Risa Mukai, Xiaoyong Xu, Sanchita Kashyap, Chun-Yang Huang, Eun-Ah Sung, Wataru Mizushima, Allen Sam Titus, Koichiro Takayama, Youssef Mourad, Jamie Francisco, Tong Liu, Tong Chen, Hong Li, Junichi Sadoshima
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Modification of cysteine residues by oxidative and nitrosative stress affects structure and function of proteins, thereby contributing to the pathogenesis of cardiovascular disease. Although the major function of thioredoxin 1 (Trx1) is to reduce dis
Externí odkaz:
https://doaj.org/article/48ab0d010c1a459fb404bff55414eefd
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102561- (2023)
Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+, thereby producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and the NADP(H)-producing mechanism are evolutionarily conserved among archaea, bacteria
Externí odkaz:
https://doaj.org/article/8bbad99939334d619f6e4955d483ec0e
Autor:
Kenji Maeda, Masayuki Amano, Yukari Uemura, Kiyoto Tsuchiya, Tomoko Matsushima, Kenta Noda, Yosuke Shimizu, Asuka Fujiwara, Yuki Takamatsu, Yasuko Ichikawa, Hidehiro Nishimura, Mari Kinoshita, Shota Matsumoto, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Shin-ichi Oka, Ayako Mikami, Wataru Sugiura, Toshiyuki Sato, Tomokazu Yoshida, Shinya Shimada, Hiroaki Mitsuya
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract While mRNA vaccines against SARS-CoV-2 are exceedingly effective in preventing symptomatic infection, their immune response features remain to be clarified. In the present prospective study, 225 healthy individuals in Japan, who received two
Externí odkaz:
https://doaj.org/article/afc0cc4016284319811206f3cc4de9a3
Autor:
Shin-ichi Oka, Karthi Sreedevi, Thirupura S. Shankar, Shreya Yedla, Sumaita Arowa, Amina James, Kathryn G. Stone, Katia Olmos, Amira D. Sabry, Amanda Horiuchi, Keiko M. Cawley, Sean A. O’very, Mingming Tong, Jaemin Byun, Xiaoyong Xu, Sanchita Kashyap, Youssef Mourad, Omair Vehra, Dallen Calder, Ty Lunde, Tong Liu, Hong Li, J. Alan Mashchek, James Cox, Yukio Saijoh, Stavros G. Drakos, Junco S. Warren
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
AimsPERM1 is a striated muscle-specific regulator of mitochondrial bioenergetics. We previously demonstrated that PERM1 is downregulated in the failing heart and that PERM1 positively regulates metabolic genes known as targets of the transcription fa
Externí odkaz:
https://doaj.org/article/3ebf8c90ae564ca6a5a114f14cb65ce0
Autor:
Toshihide Kashihara, Risa Mukai, Shin-ichi Oka, Peiyong Zhai, Yasuki Nakada, Zhi Yang, Wataru Mizushima, Tsutomu Nakahara, Junco S. Warren, Maha Abdellatif, Junichi Sadoshima
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the heart against acute blood pressure elevation. The nuclear effector of the H
Externí odkaz:
https://doaj.org/article/2bede1f3f1824fc7aaf8eccc22265fe8
Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart
Autor:
Shohei Ikeda, MD, PhD, Risa Mukai, MD, PhD, Wataru Mizushima, MD, PhD, Peiyong Zhai, MD, PhD, Shin-ichi Oka, PhD, Michinari Nakamura, MD, PhD, Dominic P. Del Re, PhD, Sebastiano Sciarretta, MD, PhD, Chiao-Po Hsu, MD, PhD, Hiroaki Shimokawa, MD, PhD, Junichi Sadoshima, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 5, Pp 611-622 (2019)
Summary: Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in d
Externí odkaz:
https://doaj.org/article/7519a040dc374d1ea5aca7248c806c2c
Autor:
Shin-Ichi Oka, Amira D Sabry, Amanda K Horiuchi, Keiko M Cawley, Sean A O'Very, Maria A Zaitsev, Thirupura S Shankar, Jaemin Byun, Risa Mukai, Xiaoyong Xu, Natalia S Torres, Anil Kumar, Masayuki Yazawa, Jing Ling, Iosif Taleb, Yukio Saijoh, Stavros G Drakos, Junichi Sadoshima, Junco S Warren
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234913 (2020)
The transcriptional regulatory machinery in mitochondrial bioenergetics is complex and is still not completely understood. We previously demonstrated that the histone methyltransferase Smyd1 regulates mitochondrial energetics. Here, we identified Per
Externí odkaz:
https://doaj.org/article/92c772a739a040259fedf9606d3c84c6
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Metabolic adaption is crucial for the heart to sustain its contractile activity under various physiological and pathological conditions. At the molecular level, the changes in energy demand impinge on the expression of genes encoding for metabolic en
Externí odkaz:
https://doaj.org/article/3a1489c67f084b24bbdea5dcf33e81d3
Autor:
Shin-ichi Oka, Fan Tang, Adave Chin, Guersom Ralda, Xiaoyong Xu, Chengchen Hu, Zhi Yang, Maha Abdellatif, Junichi Sadoshima
Publikováno v:
Antioxidants, Vol 10, Iss 7, p 1153 (2021)
Thioredoxin 1 (Trx1) is a major antioxidant that acts adaptively to protect the heart during the development of diabetic cardiomyopathy. The molecular mechanism(s) responsible for regulating the Trx1 level and/or activity during diabetic cardiomyopat
Externí odkaz:
https://doaj.org/article/f144015440d94697ba986bd010dbad74