Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Shin-Ei Matsumoto"'
Autor:
Eriko Kuramoto, Ayano Kitawaki, Takakazu Yagi, Hiroshi Kono, Shin-Ei Matsumoto, Hiromitsu Hara, Yasumasa Ohyagi, Haruki Iwai, Atsushi Yamanaka, Tetsuya Goto
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The rapid aging of the population makes the detection and prevention of frailty increasingly important. Oral frailty has been proposed as a novel frailty phenotype and is defined as a decrease in oral function coexisting with a decline in cognitive a
Externí odkaz:
https://doaj.org/article/e091174258474ba2bb6fa81597c46c7c
Autor:
Kohei Shimada, Yumiko Motoi, Koichi Ishiguro, Taiki Kambe, Shin-ei Matsumoto, Masako Itaya, Miyuki Kunichika, Hideo Mori, Atsuko Shinohara, Momoko Chiba, Yoshikuni Mizuno, Takashi Ueno, Nobutaka Hattori
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 1, Pp 101-108 (2012)
Lithium, a drug used to treat bipolar disorders, has a variety of neuroprotective mechanisms including inhibition of glycogen synthase kinase-3 (GSK-3), a major tau kinase. Recently, it has been shown that, in various neurodegenerative proteinopathie
Externí odkaz:
https://doaj.org/article/d9ce835b5c9948e1a03e196d780e7838
Autor:
Masato Hasegawa, Shin-Ei Matsumoto, Koichi Ishiguro, Montasir Elahi, Yumiko Motoi, Shotaro Shimonaka, Nobutaka Hattori
Publikováno v:
J Biol Chem
In tauopathies, tau forms pathogenic fibrils with distinct conformations (termed “tau strains”) and acts as an aggregation “seed” templating the conversion of normal tau into isomorphic fibrils. Previous research showed that the aggregation c
Autor:
Atsushi Yamanaka, Haruka Seki, Ashis Dhar, Haruki Iwai, Rachel Pei-Hsuan Wang, Shin-Ei Matsumoto, Yasumasa Ohyagi, Tetsuya Goto, Eriko Kuramoto, Makoto Michikawa, Hiromitsu Hara, Wai K. Leung, Raymond Chuen-Chung Chang
Publikováno v:
Journal of Alzheimer's Disease
Background The mesencephalic trigeminal nucleus (Vmes) is not only anatomically adjacent to the locus coeruleus (LC) but is also tightly associated with the function of the LC. The LC can be the first area in which Alzheimer's disease (AD) develops,
Autor:
Tetsuo Hayashi, Yumiko Motoi, Montasir Elahi, Nobutaka Hattori, Koichi Ishiguro, Shin-Ei Matsumoto, Shotaro Shimonaka, Masashi Takanashi
Publikováno v:
Journal of Alzheimer's disease : JAD. 79(4)
Background: Human tauopathy brain injections into the mouse brain induce the development of tau aggregates, which spread to functionally connected brain regions; however, the features of this neurotoxicity remain unclear. One reason may be short obse
Autor:
Shin-Ei Matsumoto, Yumiko Motoi, Montasir Elahi, Masato Hasegawa, Shotaro Shimonaka, Nobutaka Hattori, Koichi Ishiguro
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Takeshi Tabira, Hideo Hara, Nobutaka Hattori, Fumiko Ono, Haifeng Jin, Shinichiro Nakamura, Shin-Ei Matsumoto
Publikováno v:
Journal of Alzheimer's Disease. 54:1047-1059
With the objective to improve the amyloid-β (Aβ) targeting immunotherapy, we investigated the safety and efficacy of an oral vaccine with recombinant adeno-associated virus vector carrying a signal sequence and Aβ1-43 cDNA (rAAV/Aβ) in old non-hu
Autor:
Nobutaka Hattori, Montasir Elahi, Yumiko Motoi, Koichi Ishiguro, Zafrul Hasan, Shin-Ei Matsumoto
Publikováno v:
Neuroscience Letters. 610:207-212
Physical exercise has been identified as a preventive measure for Alzheimer's disease (AD), one of the neuropathological hallmarks of which, neurofibrillary tangles, consist of hyperphosphorylated insoluble tau. Previous studies demonstrated that lon
Publikováno v:
Juntendo Medical Journal. 62:64-69
Autor:
Nobutoshi Ito, Montasir Elahi, Shin-Ei Matsumoto, Yuanzhe Li, Teikichi Ikura, Nobutaka Hattori, Taku Hatano, Hiroyo Yoshino, Shotaro Shimonaka, Kenya Nishioka, Kaoru Mogushi, Yutaka Oji, Takeshi Sato, Sachiko Nakayama, Yumiko Motoi
Publikováno v:
Neurobiology of Aging. 84:240.e13-240.e22
Variants in the microtubule-associated protein tau (MAPT) gene cause the genetic tauopathies, a subgroup of frontotemporal dementia (FTD) disorders. Through genetic screening of 165 cases possibly associated with tauopathies, including 88 Alzheimer's