Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Shin ichi Tsukumo"'
Autor:
Yuta Suzuki, Takayuki Miyazaki, Hiroki Muto, Kenji Kubara, Yohei Mukai, Ryuji Watari, Shinya Sato, Keita Kondo, Shin-ichi Tsukumo, Koji Yasutomo, Masashi Ito, Kappei Tsukahara
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 226-240 (2022)
mRNA and lipid nanoparticles have emerged as powerful systems for the preparation of vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The emergence of novel variants or the necessity of cold chain logistics for
Externí odkaz:
https://doaj.org/article/4054f9f2cc084521a4b687b1b0017f6f
Autor:
Thiranut Jaroonwitchawan, Hideki Arimochi, Yuki Sasaki, Chieko Ishifune, Hiroyuki Kondo, Kunihiro Otsuka, Shin-ichi Tsukumo, Koji Yasutomo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved i
Externí odkaz:
https://doaj.org/article/10d0d4f4f36e4c2a9b4d00cdb554e5d3
Autor:
Michittra Boonchan, Hideki Arimochi, Kunihiro Otsuka, Tomoko Kobayashi, Hisanori Uehara, Thiranut Jaroonwitchawan, Yuki Sasaki, Shin-ichi Tsukumo, Koji Yasutomo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Abstract The sensing of various extrinsic stimuli triggers the receptor-interacting protein kinase-3 (RIPK3)-mediated signaling pathway, which leads to mixed-lineage kinase-like (MLKL) phosphorylation followed by necroptosis. Although necroptosis is
Externí odkaz:
https://doaj.org/article/918ae5c97c8642ba9746781bcc35863f
Autor:
Yuki Sasaki, Hideki Arimochi, Kunihiro Otsuka, Hiroyuki Kondo, Shin-ichi Tsukumo, Koji Yasutomo
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Immunoproteasomes regulate the degradation of ubiquitin-coupled proteins and generate peptides that are preferentially presented by MHC class I. Mutations in immunoproteasome subunits lead to immunoproteasome dysfunction, which causes proteasome-asso
Externí odkaz:
https://doaj.org/article/e652fcb390684653afd25d851afcf285
Autor:
Hiroyuki Kondo, Takahiro Kageyama, Shigeru Tanaka, Kunihiro Otsuka, Shin-ichi Tsukumo, Yoichi Mashimo, Yoshihiro Onouchi, Hiroshi Nakajima, Koji Yasutomo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BNT162b2, a nucleoside-modified mRNA vaccine for SARS-CoV-2 spike glycoprotein (S), provides approximately 95% efficacy for preventing COVID-19. However, it remains unclear how effectively memory CD8+ T cells are generated and which genetic and envir
Externí odkaz:
https://doaj.org/article/c8a6f89961f14eaa86a22696b4d4c64d
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The NLRC4 inflammasome assembles in response to detection of bacterial invasion, and NLRC4 activation leads to the production of IL-1β and IL-18 together with pyroptosis-mediated cell death. Missense activating mutations in NLRC4 cause autoinflammat
Externí odkaz:
https://doaj.org/article/8e657e3207554b1daef43e481c7e0127
Autor:
Chieko Ishifune, Shin-Ichi Tsukumo, Yoichi Maekawa, Katsuto Hozumi, Doo Hyun Chung, Chihiro Motozono, Sho Yamasaki, Hiroyasu Nakano, Koji Yasutomo
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000262 (2019)
Intestinal intraepithelial lymphocytes (IELs) expressing CD8αα on αβ T cells (TCRαβ+CD8αα+ IELs) have suppressive capabilities in enterocolitis, but the mechanism that maintains homeostasis and cell number is not fully understood. Here, we de
Externí odkaz:
https://doaj.org/article/31501fe6b3e043d59c08a695a2aa7fad
Autor:
Shin-ichi Tsukumo, Koji Yasutomo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Cancer immunosurveillance is critical for the elimination of neoplastic cells. In addition, recent advances in immunological checkpoint blockade drugs have revealed the importance of the immune system in cancer treatment. As a component of the immune
Externí odkaz:
https://doaj.org/article/64b7c0f09b4a4924bf2713852a92562a
Autor:
Shin-ichi Tsukumo, Poorani Ganesh Subramani, Noé Seija, Mizuho Tabata, Yoichi Maekawa, Yuya Mori, Chieko Ishifune, Yasushi Itoh, Mineto Ota, Keishi Fujio, Javier M. Di Noia, Koji Yasutomo
Publikováno v:
Science Advances. 8
Immunoglobulin class switch recombination (CSR) plays critical roles in controlling infections and inflammatory tissue injuries. Here, we show that AFF3 , a candidate gene for both rheumatoid arthritis and type 1 diabetes, is a molecular facilitator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4fe8f4919305a53fff5fc84458a9f3
https://doi.org/10.1126/sciadv.abq0008
https://doi.org/10.1126/sciadv.abq0008
Autor:
Hideki Arimochi, Shin-ichi Tsukumo, Hisanori Uehara, Yuki Sasaki, Thiranut Jaroonwitchawan, Kunihiro Otsuka, Tomoko Kobayashi, Koji Yasutomo, Michittra Boonchan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
The sensing of various extrinsic stimuli triggers the receptor-interacting protein kinase-3 (RIPK3)-mediated signaling pathway, which leads to mixed-lineage kinase-like (MLKL) phosphorylation followed by necroptosis. Although necroptosis is a form of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba7b1afae0a8752c632195bad349983
https://doaj.org/article/918ae5c97c8642ba9746781bcc35863f
https://doaj.org/article/918ae5c97c8642ba9746781bcc35863f