Výsledky vyhledávání - "Shin Mitsutake"

Endogenous expression of Hras G12V induces developmental defects and neoplasms with copy number imbalances of the oncogene

Autor: Eugenio Santos, Aime T. Franco, Jeffrey A. Knauf, Hans G. Wendel, Hartmut Geiger, Pat Zanzonico, Krista LaPerle, Xu Chen, Shin Mitsutake, Norisato Mitsutake, Edna Teruko Kimura, James A. Fagin, Valerie A. Longo, Nagako Akeno

Publikováno v: Proceedings of the National Academy of Sciences. 106:7979-7984

We developed mice with germline endogenous expression of oncogenic Hras to study effects on development and mechanisms of tumor initiation. They had high perinatal mortality, abnormal cranial dimensions, defective dental ameloblasts, and nasal septal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63ee1b776764794226671f9eb98bb72
https://doi.org/10.1073/pnas.0900343106

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BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis

Autor: Cleo Mesa, Norisato Mitsutake, Jeffrey A. Knauf, Shin Mitsutake, James A. Fagin, Makoto Miyagishi, Nagako Akeno, Lei Zhang, Kazunari Taira

Publikováno v: Endocrinology. 147(2)

In human papillary thyroid cancers (PTCs), mutations of RET/PTC, NTRK, RAS, or BRAF are found in about two thirds of cases with practically no overlap, providing genetic evidence that constitutive signaling along RET-RAS-BRAF-MAPK is key to their dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce4259225b2376abda24a93f5e53868
https://pubmed.ncbi.nlm.nih.gov/16254036

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