Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shin Jung C. Lee"'
Autor:
Michael W. Beck, Jeffrey S. Derrick, Richard A. Kerr, Shin Bi Oh, Woo Jong Cho, Shin Jung C. Lee, Yonghwan Ji, Jiyeon Han, Zahra Aliakbar Tehrani, Nayoung Suh, Sujeong Kim, Scott D. Larsen, Kwang S. Kim, Joo-Yong Lee, Brandon T. Ruotolo, Mi Hee Lim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
To advance our understanding of pathological features associated with Alzheimer’s disease (AD), chemical tools with distinct specificity towards AD targets would be valuable. Here the authors used a structure-mechanism-based design strategy to obta
Externí odkaz:
https://doaj.org/article/38e022ffa1474e819049faf03deff89d
Publikováno v:
Chemical Society Reviews. 46:310-323
Alzheimer's disease (AD) is characterized by an imbalance between production and clearance of amyloid-β (Aβ) species. Aβ peptides can transform structurally from monomers into β-stranded fibrils via multiple oligomeric states. Among the various A
Autor:
Oh-Hoon Kwon, Sunyoung Park, Hyun-Woo Rhee, Jung Seung Nam, Myeong-Gyun Kang, Jeong Kon Seo, Juhye Kang, Hyun-Tak Kim, Mi Hee Lim, Tae-Hyuk Kwon, Shin Jung C. Lee
Publikováno v:
Journal of the American Chemical Society. 138:10968-10977
Protein inactivation by reactive oxygen species (ROS) such as singlet oxygen ((1)O2) and superoxide radical (O2(•-)) is considered to trigger cell death pathways associated with protein dysfunction; however, the detailed mechanisms and direct invol
Autor:
Masha G. Savelieff, Juhye Kang, Elizabeth M. Nolan, Hyuck Jin Lee, Shin Jung C. Lee, Toshiki G. Nakashige, Megan Brunjes Brophy, Mi Hee Lim
Publikováno v:
Prof. Nolan via Ye Li
Proteins from the S100 family perform numerous functions and may contribute to Alzheimer's disease (AD). Herein, we report the effects of S100A8/S100A9 heterooligomer calprotectin (CP) and the S100B homodimer on metal-free and metal-bound amyloid-β
Autor:
Jiyeon Han, Seung-Hee Lee, Su Wol Chung, Juhye Kang, Mi Hee Lim, Jeffrey S. Derrick, Eunju Nam, Shin Jung C. Lee
Publikováno v:
ACS chemical neuroscience. 9(11)
A catecholamine neurotransmitter, dopamine (DA), is suggested to be linked to the pathology of dementia; however, the involvement of DA and its structural analogues in the pathogenesis of Alzheimer's disease (AD), the most common form of dementia, co
Autor:
Kyu Yeon Kim, Jaeheung Cho, Junghyun Chae, Jong-Min Suh, Mi Hee Lim, Hyuck Jin Lee, Shin Jung C. Lee, Jiyeon Han
Publikováno v:
ACS chemical neuroscience. 9(4)
Multiple pathogenic factors [e.g., amyloid-β (Aβ), metal ions, metal-bound Aβ (metal-Aβ), reactive oxygen species (ROS)] are found in the brain of patients with Alzheimer's disease (AD). In order to elucidate the roles of pathological elements in
Autor:
Mi Hee Lim, Shin Jung C. Lee, Minjeong Kim, Geewoo Nam, Jaeheung Cho, Cheol-Min Park, Yonghwan Ji, Hyuck Jin Lee
Publikováno v:
Inorganic chemistry. 56(11)
The complexity of Alzheimer's disease (AD) stems from the inter-relation of multiple pathological factors upon initiation and progression of the disease. To identify the involvement of metal-bound amyloid-β (metal-Aβ) aggregation in AD pathology, a
Autor:
Kiyoung Park, Jiwan Lee, Shin Jung C. Lee, Hyeonwoo Tak, Sun Hee Kim, Jeffrey S. Derrick, Misun Lee, Eunju Nam, Juhye Kang, Mi Hee Lim, Jaeheung Cho, Yujeong Kim
Publikováno v:
Journal of the American Chemical Society. 139(6)
An amyloidogenic peptide, amyloid-β (Aβ), has been implicated as a contributor to the neurotoxicity of Alzheimer’s disease (AD) that continues to present a major socioeconomic burden for our society. Recently, the use of metal complexes capable o
Autor:
Jong Wha Lee, Hugh I. Kim, Shin Jung C. Lee, Young Ho Ko, Tae Su Choi, Won Jong Kim, Junghong Park, Kimoon Kim, Hong Hee Lee
Publikováno v:
Angewandte Chemie. 126:7591-7595
Amyloid fibrils are insoluble protein aggregates comprised of highly ordered β-sheet structures and they are involved in the pathology of amyloidoses, such as Alzheimer's disease. A supramolecular strategy is presented for inhibiting amyloid fibrill
Publikováno v:
Journal of the American Society for Mass Spectrometry. 25:410-421
The hydration of cucurbit[6]uril (CB[6]) in the gas phase is investigated using electrospray ionization traveling wave ion mobility mass spectrometry (ESI-TWIM-MS). Highly abundant dihydrated and tetrahydrated species of diprotonated CB[6] are found