Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Shin Ichiro Kubo"'
Autor:
Shin-ichiro Kubo, Tomoyasu Matsubara, Takeshi Taguchi, Renpei Sengoku, Atsuko Takeuchi, Yuko Saito
Publikováno v:
BMC Neurology, Vol 21, Iss 1, Pp 1-7 (2021)
Abstract Background Late-stage Parkinson’s disease (PD) often presents with neuropsychiatric symptoms such as dementia, psychosis, excessive daytime sleepiness, apathy, depression, and anxiety. However, neuropsychiatric symptoms are the cardinal fe
Externí odkaz:
https://doaj.org/article/478d26e6e11b42dc97e1b572bf934328
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 3, Iss , Pp 100071- (2020)
Motor fluctuations can be seen even during treatment with continuous levodopa-carbidopa intestinal gel infusion (LCIG). We report on a middle-aged man with advanced Parkinson's disease (PD) on LCIG in which motor fluctuations have been improved with
Externí odkaz:
https://doaj.org/article/9864f5d858644a5488e41374d46b4ca8
Autor:
Toshiki, Tezuka, Takashi, Osada, Yasuo, Terayama, Masahito, Kubota, Shohei, Okusa, Gen, Shiihashi, Shin-Ichiro, Kubo, Norihiro, Suzuki, Jin, Nakahara, Morinobu, Seki
Publikováno v:
Rinsho Shinkeigaku. 62:8-14
We conducted the multicenter questionnaire survey targeting patients with Parkinson's disease (PD) in order to investigate the impacts on their daily lives and their requests to hospitals in the pandemic of severe acute respiratory syndrome coronavir
Autor:
Hideaki Matsui, Shinji Ito, Hideki Matsui, Junko Ito, Gabdulkhaev, Ramil, Mika Hirose, Tomoyuki Yamanaka, Akihide Koyama, Taisuke Kato, Maiko Tanaka, Norihito Uemura, Noriko Matsui, Sachiko Hirokawa, Maki Yoshihama, Aki Shimozawa, Shin-ichiro Kubo, Kenji Iwasaki, Masato Hasegawa, Ryosuke Takahashi, Keisuke Hirai
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/6/2023, Vol. 120 Issue 23, p1-8, 44p
Autor:
Yukiko Usami, Taku Hatano, Satoshi Imai, Shin-ichiro Kubo, Shigeto Sato, Shinji Saiki, Yoichiro Fujioka, Yusuke Ohba, Fumiaki Sato, Manabu Funayama, Hiroto Eguchi, Kaori Shiba, Hiroyoshi Ariga, Jie Shen, Nobutaka Hattori
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 3, Pp 651-662 (2011)
Parkinson's disease (PD) is a neurodegenerative disorder caused by loss of dopaminergic neurons. Although many reports have suggested that genetic factors are implicated in the pathogenesis of PD, molecular mechanisms underlying selective dopaminergi
Externí odkaz:
https://doaj.org/article/92d135c3d8e246439bc1a795efc8dce3
Autor:
Makoto Murakami, Spencer Spratt, Akio Mori, Kei Yamamoto, Kahori Shiba-Fukushima, Takashi Nonaka, Takahiro Koinuma, Yoshimi Miki, Hideo Shindou, Tetsuya Hirabayashi, Tsuyoshi Inoshita, Yuzuru Imai, Shin-ichiro Kubo, Changxu Cui, Yoshikazu Takahashi, Masato Hasegawa, Taku Hatano, Chikara Yamashita, Ayami Okuzumi, Hongrui Meng, Nobutaka Hattori
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The mechanisms of α-synuclein aggregation and subsequent Lewy body formation are a key pathogenesis of Parkinson’s disease (PD). PARK14-linked PD, which is caused by mutations of the iPLA2-VIA/PLA2G6 gene, exhibits a marked Lewy body
Autor:
Mari Suzuki, Byung Chul Jung, Kenya Nishioka, Yuanzhe Li, Phil Hyu Lee, He Jin Lee, Nobutaka Hattori, Minsun Choi, Hideki Mochizuki, Seung-Jae Lee, Dong Kyu Kim, YuHong Fu, Han Soo Yoo, Ryusuke Sakai, Yoshitaka Nagai, Mitsuyoshi Nakatani, Woojin S. Kim, Glenda M. Halliday, Manabu Funayama, Tomoko Nakazato, Morio Ueyama, Sergio Pablo Sardi, Jun Sung Lee, Hiroyo Yoshino, Satoko Sekimoto, Kyu Won Oh, Shin Ichiro Kubo, Kazuaki Kanai
Publikováno v:
Brain. 142:2845-2859
Mutations in lysosomal genes increase the risk of neurodegenerative diseases, as is the case for Parkinson’s disease. Here, we found that pathogenic and protective mutations in arylsulfatase A (ARSA), a gene responsible for metachromatic leukodystr
Publikováno v:
Clinical Parkinsonism & Related Disorders
Clinical Parkinsonism & Related Disorders, Vol 3, Iss, Pp 100071-(2020)
Clinical Parkinsonism & Related Disorders, Vol 3, Iss, Pp 100071-(2020)
Motor fluctuations can be seen even during treatment with continuous levodopa-carbidopa intestinal gel infusion (LCIG). We report on a middle-aged man with advanced Parkinson's disease (PD) on LCIG in which motor fluctuations have been improved with
Autor:
Shin-ichiro Kubo, Tatsuo Yamada, Masahiro Nomoto, Yoshio Tsuboi, Masahiro Nagai, Akira Tamaoka, Nobutaka Hattori
Publikováno v:
Clinical Neuropharmacology. 38:241-247
Objectives This study is the first controlled trial to evaluate the efficacy and safety of subcutaneous apomorphine in Japanese patients with advanced Parkinson disease. Methods A phase II, multicenter, randomized, double-blind, parallel-group trial
Publikováno v:
Frontiers in Bioscience. 20:263-279
Parkinson's disease (PD) is one of the most common neurodegenerative diseases affecting an increasing number of people worldwide with the aging society. Although the etiology of PD remains largely unknown, it is now clear that genetic factors contrib