Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Shin‐ichiro Kanno"'
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-11 (2023)
Abstract Leucine zipper-like transcriptional regulator 1 (LZTR1), a substrate adaptor of Cullin 3 (CUL3)-based E3 ubiquitin ligase, regulates proteostasis of the RAS subfamily. Mutations in LZTR1 have been identified in patients with several types of
Externí odkaz:
https://doaj.org/article/fc4ff836fd52453686eb361b1da64f91
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
The ubiquitin specific protease 39 (USP39) interacts with the transcription factor and cytoplasmic regulator of planar cell polarity (PCP), Grainyheadlike 3 (Grhl3). USP39-dependent PCP gene upregulation contributes to epithelial morphogenesis.
Externí odkaz:
https://doaj.org/article/203bdbe720474f7eaf2c4f5ac69daebe
Autor:
Keiichi Tamai, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Shin-Ichiro Kanno, Akira Yasui, Mai Mochizuki, Wataru Iwai, Yuta Wakui, Makoto Abue, Kuniharu Yamamoto, Koh Miura, Masamichi Mizuma, Michiaki Unno, Sadafumi Kawamura, Ikuro Sato, Jun Yasuda, Kazunori Yamaguchi, Kazuo Sugamura, Kennichi Satoh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Cancer stem cells (CSCs) define a subpopulation of cancer cells that are resistant to therapy. However, little is known of how CSC characteristics are regulated. We previously showed that dormant cancer stem cells are enriched with a CD274lo
Externí odkaz:
https://doaj.org/article/46f507a261a544359c2ee01e6ca995c1
Autor:
Yuki Hiradate, Ryua Harima, Rin Yanai, Kenshiro Hara, Kazue Nagasawa, Makoto Osada, Tomoe Kobayashi, Makoto Matsuyama, Shin‐ichiro Kanno, Akira Yasui, Kentaro Tanemura
Publikováno v:
Reproductive Medicine and Biology, Vol 21, Iss 1, Pp n/a-n/a (2022)
Abstract Purpose Spermiogenesis, the process of deformation of sperm head morphology and flagella formation, is a phenomenon unique to sperm. Axonemal dynein light chain proteins are localized to sperm flagella and are known to be involved in sperm m
Externí odkaz:
https://doaj.org/article/4f0e21a557254dd9b7ba113467a40b13
Autor:
Tetsuro Matsuhashi, Takeya Sato, Shin-ichiro Kanno, Takehiro Suzuki, Akihiro Matsuo, Yuki Oba, Motoi Kikusato, Emi Ogasawara, Tai Kudo, Kosuke Suzuki, Osamu Ohara, Hiroko Shimbo, Fumika Nanto, Hiroaki Yamaguchi, Daisuke Saigusa, Yasuno Mukaiyama, Akiko Watabe, Koichi Kikuchi, Hisato Shima, Eikan Mishima, Yasutoshi Akiyama, Yoshitsugu Oikawa, HO Hsin-Jung, Yukako Akiyama, Chitose Suzuki, Mitsugu Uematsu, Masaki Ogata, Naonori Kumagai, Masaaki Toyomizu, Atsushi Hozawa, Nariyasu Mano, Yuji Owada, Setsuya Aiba, Teruyuki Yanagisawa, Yoshihisa Tomioka, Shigeo Kure, Sadayoshi Ito, Kazuto Nakada, Ken-ichiro Hayashi, Hitoshi Osaka, Takaaki Abe
Publikováno v:
EBioMedicine, Vol 20, Iss C, Pp 27-38 (2017)
Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders. Several antioxidant therapies and drugs affecting mitochondrial biogenesis are undergoing investigation, although not all of them have demonstrated favor
Externí odkaz:
https://doaj.org/article/a69fd02b6914423ab9feee99f60fd27a
Autor:
Satoshi Okano, Akira Yasui, Shin-ichiro Kanno, Kennichi Satoh, Masahiko Igarashi, Osamu Nakajima
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Our earlier studies demonstrated that cysteine414- (zinc-binding site of mCRY1-) alanine mutant mCRY1 transgenic mice (Tg mice) exhibit diabetes characterized by the reduction of β-cell proliferation and by β-cell dysfunction, presumably caused by
Externí odkaz:
https://doaj.org/article/ba38f06fd21e400a953dfcc0bb1362f1
Autor:
Takashi Kohno, Aikou Okamoto, Yasushi Okuno, Hiroyuki Mano, Masakazu Sekijima, Akira Yasui, Yukari Sagae, Shigeyuki Matsumoto, Keiko Miyoshi, Shin-ichiro Kanno, Ayako Ui, Masachika Ikegami, Ayaka Otsuka, Shinji Kohsaka, Ryunosuke Yoshino, Mitsugu Araki, Takashi Nakaoku, Junya Tabata
Supplementary Table from Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a4dbf0838ee6bcb973084d0999cd8a
https://doi.org/10.1158/0008-5472.22431953.v1
https://doi.org/10.1158/0008-5472.22431953.v1
Autor:
Takashi Kohno, Aikou Okamoto, Yasushi Okuno, Hiroyuki Mano, Masakazu Sekijima, Akira Yasui, Yukari Sagae, Shigeyuki Matsumoto, Keiko Miyoshi, Shin-ichiro Kanno, Ayako Ui, Masachika Ikegami, Ayaka Otsuka, Shinji Kohsaka, Ryunosuke Yoshino, Mitsugu Araki, Takashi Nakaoku, Junya Tabata
Supplementary Data from Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2332f3d7e4ca835c48eb6ee536660cc6
https://doi.org/10.1158/0008-5472.22431980
https://doi.org/10.1158/0008-5472.22431980
Autor:
Takashi Kohno, Aikou Okamoto, Yasushi Okuno, Hiroyuki Mano, Masakazu Sekijima, Akira Yasui, Yukari Sagae, Shigeyuki Matsumoto, Keiko Miyoshi, Shin-ichiro Kanno, Ayako Ui, Masachika Ikegami, Ayaka Otsuka, Shinji Kohsaka, Ryunosuke Yoshino, Mitsugu Araki, Takashi Nakaoku, Junya Tabata
Distinguishing oncogenic mutations from variants of unknown significance (VUS) is critical for precision cancer medicine. Here, computational modeling of 71,756 RET variants for positive selection together with functional assays of 110 representative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c73b3214a9408945f8b51085a44eb5b7
https://doi.org/10.1158/0008-5472.c.6514040.v1
https://doi.org/10.1158/0008-5472.c.6514040.v1
Autor:
Takashi Kohno, Aikou Okamoto, Yasushi Okuno, Hiroyuki Mano, Masakazu Sekijima, Akira Yasui, Yukari Sagae, Shigeyuki Matsumoto, Keiko Miyoshi, Shin-ichiro Kanno, Ayako Ui, Masachika Ikegami, Ayaka Otsuka, Shinji Kohsaka, Ryunosuke Yoshino, Mitsugu Araki, Takashi Nakaoku, Junya Tabata
Supplementary Figure from Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260e34aeed80d1f60a6705138596d6e4
https://doi.org/10.1158/0008-5472.22431968.v1
https://doi.org/10.1158/0008-5472.22431968.v1