Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Shin‐ichi Kawaguchi"'
Autor:
Tomotaka Nagasawa, Masaki Horitani, Shin‐ichi Kawaguchi, Shigeki Higashiyama, Yoichiro Hama, Susumu Mitsutake
Publikováno v:
FEBS Open Bio, Vol 11, Iss 11, Pp 3081-3089 (2021)
Free fatty acid receptor 4 (FFAR4)/GPR120 comprises a receptor for medium‐ and long‐chain fatty acids. We previously identified phytosphingosine (PHS) as a novel ligand of FFAR4. Although many natural FFAR4 ligands have carboxyl groups, PHS does
Externí odkaz:
https://doaj.org/article/fe7b075bd2064db99a4e381cddb5c74c
Autor:
Dat Phuc Tran, Yuki Sato, Yuki Yamamoto, Shin-ichi Kawaguchi, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 866-872 (2021)
The homolytic cleavage of the PV(O)–PIII bond in tetraphenyldiphosphine monoxide simultaneously provides both pentavalent and trivalent phosphorus-centered radicals with different reactivities. The method using V-40 as an initiator is successfully
Externí odkaz:
https://doaj.org/article/934bba3109fb449ca3871f41e41c7cfa
Autor:
Chun-ping Dong, Kentaro Nakamura, Toshihide Taniguchi, Soichiro Mita, Shintaro Kodama, Shin-ichi Kawaguchi, Akihiro Nomoto, Akiya Ogawa, Takumi Mizuno
Publikováno v:
ACS Omega, Vol 3, Iss 8, Pp 9814-9821 (2018)
Externí odkaz:
https://doaj.org/article/603389a24fc94ce88fb154615d6dd854
Autor:
Takafumi Suzuki, Aki Muramatsu, Ryota Saito, Tatsuro Iso, Takahiro Shibata, Keiko Kuwata, Shin-ichi Kawaguchi, Takao Iwawaki, Saki Adachi, Hiromi Suda, Masanobu Morita, Koji Uchida, Liam Baird, Masayuki Yamamoto
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 746-758.e4 (2019)
Summary: The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains poorly understood. Here, we show that a Keap1 mutant lacking 11 cysteine residues r
Externí odkaz:
https://doaj.org/article/8f429184c0984c30b6ecf2c024ee31bf
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 1141-1147 (2013)
A novel method of photoinduced synthesis of unsymmetrical diaryl selenides from triarylbismuthines and diaryl diselenides has been developed. Although the arylation reactions with triarylbismuthines are usually catalyzed by transition-metal complexes
Externí odkaz:
https://doaj.org/article/b44667b7cd9c486e9d5f9933cc0f68e9
Autor:
Shin-ichi Kawaguchi, Yuhei Gonda, Takuya Yamamoto, Yuki Sato, Hiroyuki Shinohara, Yohsuke Kobiki, Atsuhiko Ichimura, Takashi Dan, Motohiro Sonoda, Toshio Miyata, Akiya Ogawa, Tadayuki Tsujita
Publikováno v:
Molecules, Vol 23, Iss 4, p 885 (2018)
Induction of a series of anti-hypoxic proteins protects cells during exposure to hypoxic conditions. Hypoxia-inducible factor-α (HIF-α) is a major transcription factor that orchestrates this protective effect. To activate HIF exogenously, without e
Externí odkaz:
https://doaj.org/article/57c2d53b449348bb8febbd147cb03896
Publikováno v:
Inorganics, Vol 5, Iss 1, p 5 (2017)
P-Fluorous phosphine (R2PRf), in which the perfluoroalkyl group is directly bonded to the phosphorus atom, is a promising ligand because it has a hybrid functionality, i.e., electron-poor and fluorous ligands. However, examples of P-fluorous phosphin
Externí odkaz:
https://doaj.org/article/b388d4a8847b41139952bc4afc408cdc
Autor:
Kento Sonoda, Sudarma Bogahawaththa, Akito Katayama, Saki Ujike, Sae Kuroki, Naho Kitagawa, Kohichi Hirotsuru, Norio Suzuki, Toshio Miyata, Shin-ichi Kawaguchi, Tadayuki Tsujita
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Hypoxia-inducible factor-α (HIF-α) activation has shown promising results in the treatment of ischemia, such as stroke, myocardial infarction, and chronic kidney disease. A number of HIF-α activators have been developed to improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc97e3d5325117dacf642c693d734cb
https://doi.org/10.1021/acsptsci.2c00002
https://doi.org/10.1021/acsptsci.2c00002
Autor:
Bogahawaththa, Sudarma, Tomoaki Kawamura, Bandaranayake, Udari, Tomoaki Hirakawa, Goki Yamada, Hana Ishino, Tsuzumi Hirohashi, Shin-ichi Kawaguchi, Wijesundera, Kavindra K., Wijayagunawardane, Missaka P. B., Kanji Ishimaru, Kodithuwakku, Suranga P., Tadayuki Tsujita
Publikováno v:
Bioscience, Biotechnology & Biochemistry; Nov2023, Vol. 87 Issue 11, p1295-1309, 15p
Autor:
Kento Sonoda, Saki Ujike, Akito Katayama, Norio Suzuki, Shin-ichi Kawaguchi, Tadayuki Tsujita
Publikováno v:
Bioorganicmedicinal chemistry. 73
Hypoxia-inducible factor (HIF) activators aid the treatment of renal anemia and ischemia. Recently, PyrzA (5-(1-acetyl-5-phenylpyrazolidin-3-ylidene)-1,3-dimethylbarbituric acid), a HIF activator by PHD inhibition without a 2-oxoglutarate moiety was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bcb04a63b472646bcd0488577fcf1c0
https://pubmed.ncbi.nlm.nih.gov/36198217
https://pubmed.ncbi.nlm.nih.gov/36198217