Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shin, Takusagawa"'
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 43:301-309
Mirabegron is cleared by multiple mechanisms, including drug-metabolizing enzymes. One of the most important clearance pathways is direct glucuronidation. In humans, M11 (O-glucuronide), M13 (carbamoyl-glucuronide), and M14 (N-glucuronide) have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3df7c14c9436caf16e9b07bd187d290
https://doi.org/10.1007/s13318-017-0450-x
https://doi.org/10.1007/s13318-017-0450-x
Publikováno v:
Clinical Therapeutics. 37:1031-1044
Purpose The objective of these studies was to evaluate the pharmacokinetic profile, safety, and tolerability of mirabegron, a β 3 -adrenoceptor agonist for the treatment of overactive bladder, including food effects (low- or high-fat meals) and sex,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e95fbc0d292bcec7c3cb446b5003ce1
https://doi.org/10.1016/j.clinthera.2015.02.021
https://doi.org/10.1016/j.clinthera.2015.02.021
Autor:
Virginie Kerbusch, Walter Krauwinkel, Selina Moy, Alan Marion, Donna Kowalski, Michael Roy, James Keirns, Taiji Sawamoto, Jennifer Lee, Marcel van Gelderen, John Meijer, Shin Takusagawa
Publikováno v:
Clinical Drug Investigation. 33:429-440
Mirabegron is a β3-adrenoceptor agonist for the treatment of overactive bladder. There has been little information published or presented about the involvement of cytochrome P450 (CYP) isoenzymes 3A and 2D6 in the metabolism of mirabegron in humans;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e77f60f4009cebac2dbca806031d271
https://doi.org/10.1007/s40261-013-0084-y
https://doi.org/10.1007/s40261-013-0084-y
Autor:
Virginie Kerbusch, Yutaka Takahashi, Hiroyuki Nemoto, Fumihiko Ushigome, Takafumi Iwatsubo, Aiji Miyashita, Shin Takusagawa, Takashi Usui, Qun Li
Publikováno v:
Molecular Pharmaceutics. 10:1783-1794
Mirabegron, a weak-basic compound, is a potent and selective β3-adrenoceptor agonist for the treatment of overactive bladder. Mirabegron extended release formulation shows dose-dependent oral bioavailability in humans, which is likely attributable t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a98dd740c50d53eaeec7bea42176f7da
https://doi.org/10.1021/mp300582s
https://doi.org/10.1021/mp300582s
Autor:
Shin, Takusagawa, Fumihiko, Ushigome, Hiroyuki, Nemoto, Yutaka, Takahashi, Qun, Li, Virginie, Kerbusch, Aiji, Miyashita, Takafumi, Iwatsubo, Takashi, Usui
Publikováno v:
Molecular pharmaceutics. 10(5)
Mirabegron, a weak-basic compound, is a potent and selective β3-adrenoceptor agonist for the treatment of overactive bladder. Mirabegron extended release formulation shows dose-dependent oral bioavailability in humans, which is likely attributable t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1285a218200d4a9b21f1b7c07dde5bce
https://pubmed.ncbi.nlm.nih.gov/23560393
https://pubmed.ncbi.nlm.nih.gov/23560393
Publikováno v:
Plant Science. 121:167-174
A cDNA library was constructed with poly(A) + RNA prepared from 10-day-old rice seedlings. We have isolated three nuclear genes, rpl 13, rpl 24 and rpl 28, that encode chloroplast ribosomal proteins L13, L24 and L28, respectively. Comparison with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ee69f651900e95f83ccd2e3fafa4a4d
https://doi.org/10.1016/s0168-9452(96)04516-5
https://doi.org/10.1016/s0168-9452(96)04516-5
Autor:
Takafumi Iwatsubo, Shotaro Uehara, Aiji Miyashita, Kanako Yajima, Shin Takusagawa, Takashi Usui
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 42(10)
1. Human cytochrome P450 (CYP) enzymes and esterases involved in the metabolism of mirabegron, a potent and selective human β(3)-adrenoceptor agonist intended for the treatment of overactive bladder, were identified in in vitro studies. 2. Incubatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbad2ce61edd5cb23be7643647ac3bb
https://pubmed.ncbi.nlm.nih.gov/22509825
https://pubmed.ncbi.nlm.nih.gov/22509825
Autor:
Aiji Miyashita, Marloes Schaddelee, Katsuhiro Suzuki, Marcel van Gelderen, John Meijer, Takafumi Iwatsubo, Mitsuhiro Sekiguchi, Walter Krauwinkel, Masanori Nagata, Jan Jaap van Lier, Shin Takusagawa, Takashi Usui
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 40(4)
The mass balance and metabolite profiles of 2-(2-amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)[U-(14)C]phenyl]acetamide ([(14)C]mirabegron, YM178), a β(3)-adrenoceptor agonist for the treatment of overactive bladder, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2c786fc0147610c1864f1cda9bbd9e
https://pubmed.ncbi.nlm.nih.gov/22269146
https://pubmed.ncbi.nlm.nih.gov/22269146
Autor:
Raymond van Teijlingen, Shin Takusagawa, Takashi Usui, Marcel van Gelderen, Cas van den Beld, John Meijer
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
Mirabegron is being developed for the treatment of overactive bladder. To support the development of mirabegron, including pharmacokinetic studies, liquid chromatography/tandem mass spectrometry methods for mirabegron and eight metabolites (M5, M8, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c98ef296392103eb5adcd3635215a1
https://pubmed.ncbi.nlm.nih.gov/22317789
https://pubmed.ncbi.nlm.nih.gov/22317789
Autor:
Mikio Nakazono, Shin-ichi Arimura, Shoji Hatano, Shin Takusagawa, Atsushi Hirai, Nobuhiro Tsutsumi
Publikováno v:
FEBS letters. 450(3)
We have cloned a novel nuclear gene for a ribosomal protein of rice and Arabidopsis that is like the bacterial ribosomal protein S9. To determine the subcellular localization of the gene product, we fused the N-terminal region and green fluorescent p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8582f6064e7feaa2297eb48630443c
https://pubmed.ncbi.nlm.nih.gov/10359080
https://pubmed.ncbi.nlm.nih.gov/10359080