Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer

Autor: Park, Soon Sang, Lee, Young-Kyoung, Choi, Yong Won, Lim, Su Bin, Park, So Hyun, Kim, Han Ki, Shin, Jun Sang, Kim, Young Hwa, Lee, Dong Hyun, Kim, Jang-Hee, Park, Tae Jun

Publikováno v: In Cell Reports 26 March 2024 43(3)

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Senescent tumor cells in colorectal cancer are characterized by elevated enzymatic activity of complexes 1 and 2 in oxidative phosphorylation.

Autor: Shin JS; Department of Surgery, Ajou University School of Medicine, Suwon, Korea., Kim TG; Department of Pathology, Ajou University School of Medicine, Suwon, Korea., Kim YH; Department of Pathology, Ajou University School of Medicine, Suwon, Korea.; Inflamm-Aging Translational Research Center, Ajou University Hospital, Suwon, Korea., Eom SY; Department of Pathology, Ajou University School of Medicine, Suwon, Korea., Park SH; Department of Pathology, Ajou University School of Medicine, Suwon, Korea.; Inflamm-Aging Translational Research Center, Ajou University Hospital, Suwon, Korea., Lee DH; Inflamm-Aging Translational Research Center, Ajou University Hospital, Suwon, Korea.; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea., Park TJ; Inflamm-Aging Translational Research Center, Ajou University Hospital, Suwon, Korea.; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea., Park SS; Inflamm-Aging Translational Research Center, Ajou University Hospital, Suwon, Korea.; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea., Kim JH; Department of Pathology, Ajou University School of Medicine, Suwon, Korea.; Inflamm-Aging Translational Research Center, Ajou University Hospital, Suwon, Korea.; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea.

Publikováno v: Journal of pathology and translational medicine [J Pathol Transl Med] 2023 Nov; Vol. 57 (6), pp. 305-314. Date of Electronic Publication: 2023 Nov 07.