Combination of apoptotic T cell induction and self-peptide administration for therapy of experimental autoimmune encephalomyelitisResearch in the context

Autor: Shimpei Kasagi, Dandan Wang, Pin Zhang, Peter Zanvit, Hua Chen, Dunfang Zhang, Jia Li, Li Che, Takashi Maruyama, Hiroko Nakatsukasa, Ruiqing Wu, Wenwen Jin, Lingyun Sun, WanJun Chen

Publikováno v: EBioMedicine, Vol 44, Iss , Pp 50-59 (2019)

Background: Clinical trials on multiple sclerosis with repeated injections of monoclonal antibodies depleting CD4+ T cells have not resulted in much success as a disease therapy. Here, we developed an immunotherapy for EAE in mice by combining a tran

Externí odkaz: https://doaj.org/article/d4d0b41ec287418da99f8fefae91362d

D-mannose induces regulatory T cells and suppresses immunopathology

Autor: Zi-Jiang Chen, Wenwen Jin, Ruiqing Wu, Qianming Chen, Wanjun Chen, Nathan Goldberg, Cheryl Chia, Lingyun Sun, Hiroko Nakatsukasa, Joanne E. Konkel, Shimpei Kasagi, Peter Zanvit, Dunfang Zhang, Xue Jiao

Publikováno v: Zhang, D, Chia, C, Jiao, X, Jin, W, Kasagi, S, Wu, R, Konkel, J, Nakatsukasa, H, Zanvit, P, Goldberg, N, Chen, Q, Sun, L, Chen, Z-J & Chen, W J 2017, ' D-mannose induces regulatory T cells and suppresses immunopathology ', Nature Medicine, vol. 23, pp. 1036-1045 . https://doi.org/10.1038/nm.4375

D-mannose, a C-2 epimer of glucose, exists naturally in many plants and fruits, and is found in human blood at concentrations less than one-fiftieth of that of glucose. However, although the roles of glucose in T cell metabolism, diabetes and obesity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f877d4f3e20056996583c8f5e24f94
https://doi.org/10.1038/nm.4375

SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

Autor: Shimpei Kasagi, Chiyo Kurimoto, Siti Nur Aisyah Jauharoh, Shunichi Kumagai, Takeshi Sugimoto, Osamu Tokuno, Daisuke Sugiyama, Seiji Kawano, Yuji Nakamachi, Bambang Ardianto, Jun Saegusa

Publikováno v: Biochemical and Biophysical Research Communications. 417:582-587

SS-A/Ro52 (Ro52), an autoantigen in systemic autoimmune diseases such as systemic lupus erythematosus and Sjogren’s syndrome, has E3 ligase activity to ubiquitinate proteins that protect against viral infection. To investigate Ro52’s role during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d78d2512e2816aaa4b815047b69158c
https://doi.org/10.1016/j.bbrc.2011.12.010

Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome

Autor: Shigeo Murata, Kunihiro Ichinose, Makito Hirano, Akira Kinoshita, Hideki Nakamura, Nobuo Kanazawa, Kazuhiko Arima, Norio Niikawa, Katsumi Eguchi, Koh-ichiro Yoshiura, Akio Yamakawa, Atsushi Kawakami, Itaru Toyoshima, Shunichi Kumagai, Tsuneyo Mimori, Masami Tanaka, Koichiro Ohmura, Hiroyuki Mishima, Shimpei Kasagi, Hirotoshi Sugino, Satoshi Ueno, Hiroaki Ida, Masahiro Matsunaka, Keiko Tanaka, Seiji Kawano, Keiji Tanaka, Takeumi Kaneko, Akira Tsujino, Tsunehiro Mizushima, Fukumi Furukawa

Publikováno v: Proceedings of the National Academy of Sciences. 108:14914-14919

Nakajo-Nishimura syndrome (NNS) is a disorder that segregates in an autosomal recessive fashion. Symptoms include periodic fever, skin rash, partial lipomuscular atrophy, and joint contracture. Here, we report a mutation in the human proteasome subun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744a45541d66e605ee69ed941da4e62a
https://doi.org/10.1073/pnas.1106015108

Epidural spinal tumor and periaortitis as rare complications of Wegener’s granulomatosis

Autor: Akio Morinobu, Takeshi Sugimoto, Natsuko Miura, Kotaro Nishida, Shimpei Kasagi, S. Sendo, Kenichiro Kakutani, Jun Saegusa, Goh Tsuji, Seiji Kawano, Shunichi Kumagai, Hiroki Hayashi

Publikováno v: Modern Rheumatology. 21:678-683

This case report describes findings in a 61-year-old woman who manifested scleritis, small pulmonary nodules, otitis media, periaortitis, and progressive epidural spinal tumor, associated with elevated serum myeloperoxidase anti-neutrophil cytoplasmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba3d09ff032722584613a2c4426462a
https://doi.org/10.1007/s10165-011-0456-1