Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Shimon Lecht"'
Autor:
Shimon Lecht, Adi Lahiani, Michal Klazas, Majdi Saleem Naamneh, Limor Rubin, Jiayi Dong, Wenhua Zheng, Philip Lazarovici
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1592 (2024)
Rasagiline (Azilect®) is a selective monoamine oxidase B (MAO-B) inhibitor that provides symptomatic benefits in Parkinson’s disease (PD) treatment and has been found to exert preclinical neuroprotective effects. Here, we investigated the neuropro
Externí odkaz:
https://doaj.org/article/c398299d621e4cf19d068d4532ba31e4
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14669-14688 (2013)
In this study, we present the applicability of imaging epidermal growth factor (EGF) receptor levels in preclinical models of COLO205 carcinoma cells in vitro, mice with orthotopic tumors and ex vivo colorectal tumor biopsies, using EGF-labeled with
Externí odkaz:
https://doaj.org/article/46611c10497f49f9900965d59bf2d064
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 9, Pp 3513-3528 (2010)
The use of stem cells for reparative medicine was first proposed more than three decades ago. Hematopoietic stem cells from bone marrow, peripheral blood and human umbilical cord blood (CB) have gained major use for treatment of hematological indicat
Externí odkaz:
https://doaj.org/article/2e32495cb5ab41d3a2149c9dcf572e5c
Autor:
Gadi Cohen, Shimon Lecht, Hadar Arien-Zakay, Keren Ettinger, Orit Amsalem, Mor Oron-Herman, Eylon Yavin, Diana Prus, Simon Benita, Aviram Nissan, Philip Lazarovici
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48803 (2012)
Novel strategies that target the epidermal growth factor receptor (EGFR) have led to the clinical development of monoclonal antibodies, which treat metastatic colorectal cancer (mCRC) but only subgroups of patients with increased wild type KRAS and E
Externí odkaz:
https://doaj.org/article/11914d3ec36447508208142f252a6312
Autor:
Simon Benita, Philip Lazarovici, Shimon Lecht, Shimon Farber, Oshrat Harush-Frenkel, Suha Attili-Qadri, Taher Nassar
Supplementary Methods from High Plasma Levels and Effective Lymphatic Uptake of Docetaxel in an Orally Available Nanotransporter Formulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57bbc266d95bfe5a807eea38ed77076e
https://doi.org/10.1158/0008-5472.22390695
https://doi.org/10.1158/0008-5472.22390695
Autor:
Simon Benita, Philip Lazarovici, Shimon Lecht, Shimon Farber, Oshrat Harush-Frenkel, Suha Attili-Qadri, Taher Nassar
Docetaxel, an efficient chemotherapeutic drug, exhibits low and variable oral bioavailability due to the active efflux by P-glycoprotein (P-gp) and more so to CYP3A4 gut metabolism. Using a spray-drying technique, docetaxel was incorporated in PLGA [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb645007883301ed99d47ac042c0da2
https://doi.org/10.1158/0008-5472.c.6503025.v1
https://doi.org/10.1158/0008-5472.c.6503025.v1
Autor:
Ernesto Goulart, Peter I. Lelkes, Collin T. Stabler, Mark J. Mondrinos, Shimon Lecht, Philip Lazarovici
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 309:L1273-L1285
There is a clear unmet clinical need for novel biotechnology-based therapeutic approaches to lung repair and/or replacement, such as tissue engineering of whole bioengineered lungs. Recent studies have demonstrated the feasibility of decellularizing
Publikováno v:
British Medical Bulletin. 115:45-56
Mesenchymal stem cells (MSCs) of different biological sources are in Phase 1 clinical trials and are being considered for Phase 2 therapy of lung disorders, and lung (progenitor) cells derived from pluripotent stem cells (SCs) are under development i
Autor:
Collin T. Stabler, Shimon Lecht, Peter I. Lelkes, Pimchanok Pimton, Edward S. Schulman, Gregg J. Johannes
Publikováno v:
Stem Cells and Development. 24:663-676
We investigated the effects of hypoxia on spontaneous (SP)- and activin A (AA)-induced definitive endoderm (DE) differentiation of mouse embryonic stem cells (mESCs) and their subsequent differentiation into distal pulmonary epithelial cells. SP diff
Autor:
Shimon Lecht, Pimchanok Pimton, Edward S. Schulman, Collin T. Stabler, Cezary Marcinkiewicz, Jonathan A. Gerstenhaber, Seda Karamil, Peter I. Lelkes
Publikováno v:
Stem Cells and Development. 23:1923-1936
Conditioned media (CM) of transformed cells, such as the human lung-derived A549 cells, is a useful tool for directing differentiation of embryonic stem cells (ESCs). Previous work indicates that A549-CM induced pulmonary differentiation of mouse ESC