Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Shimon Efrat"'
Autor:
Shimon Efrat
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
Incomplete reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) may be responsible for the heterogeneity in differentiation capacity observed among iPSC lines. It remains unclear whether it results from stochastic reprogramming
Externí odkaz:
https://doaj.org/article/7abed81ee99d461c995e93eee36e2b45
Autor:
Matthias Thurner, Liraz Shenhav, Agata Wesolowska-Andersen, Amanda J. Bennett, Amy Barrett, Anna L. Gloyn, Mark I. McCarthy, Nicola L. Beer, Shimon Efrat
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1395-1405 (2017)
Summary: Current in vitro islet differentiation protocols suffer from heterogeneity and low efficiency. Induced pluripotent stem cells (iPSCs) derived from pancreatic beta cells (BiPSCs) preferentially differentiate toward endocrine pancreas-like cel
Externí odkaz:
https://doaj.org/article/360745dbf49245938e5f9920d168e8d8
Autor:
Ginat Toren-Haritan, Shimon Efrat
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139168 (2015)
In-vitro expansion of insulin-producing cells from adult human pancreatic islets could provide an abundant cell source for diabetes therapy. However, proliferation of β-cell-derived (BCD) cells is associated with loss of phenotype and epithelial-mes
Externí odkaz:
https://doaj.org/article/194589c5626f484e800eb458410145ce
Autor:
Gili Nathan, Sharon Kredo-Russo, Tamar Geiger, Ayelet Lenz, Haggai Kaspi, Eran Hornstein, Shimon Efrat
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122108 (2015)
In-vitro expansion of β cells from adult human pancreatic islets could provide abundant cells for cell replacement therapy of diabetes. However, proliferation of β-cell-derived (BCD) cells is associated with dedifferentiation. Here we analyzed chan
Externí odkaz:
https://doaj.org/article/fd6c2cf200ed4acf808393390972f27d
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112914 (2014)
In vitro expansion of adult human islet β cells is an attractive solution for the shortage of tissue for cell replacement therapy of type 1 diabetes. Using a lineage tracing approach we have demonstrated that β-cell-derived (BCD) cells rapidly dedi
Externí odkaz:
https://doaj.org/article/2481a3b7c0b34e3385a046574e4a0a09
Autor:
Holger A Russ, Elad Sintov, Leeat Anker-Kitai, Orr Friedman, Ayelet Lenz, Ginat Toren, Chen Farhy, Metsada Pasmanik-Chor, Varda Oron-Karni, Philippe Ravassard, Shimon Efrat
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25566 (2011)
Expansion of beta cells from the limited number of adult human islet donors is an attractive prospect for increasing cell availability for cell therapy of diabetes. However, attempts at expanding human islet cells in tissue culture result in loss of
Externí odkaz:
https://doaj.org/article/095836500806439793422aece474e0a8
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6417 (2009)
BackgroundIn-vitro expansion of functional beta cells from adult human islets is an attractive approach for generating an abundant source of cells for beta-cell replacement therapy of diabetes. Using genetic cell-lineage tracing we have recently show
Externí odkaz:
https://doaj.org/article/85d23842520341a0a2e0a91440f65807
Autor:
Dalit Landesman-Milo, Manju Surana, Irina Berkovich, Amelia Compagni, Gerhard Christofori, Norman Fleischer, Shimon Efrat
Publikováno v:
Cell Transplantation, Vol 10 (2001)
Pancreatic β cell lines may offer an abundant source of cells for β-cell replacement in type I diabetes. Using regulatory elements of the bacterial tetracycline (tet) operon for conditional expression of SV40 T antigen oncoprotein in transgenic mou
Externí odkaz:
https://doaj.org/article/ba908be053704639b8fb345fe4585a92
Autor:
Shimon Efrat
Publikováno v:
Stem cells (Dayton, Ohio)References. 37(10)
Type 2 diabetes (T2D) is caused by an inherited predisposition to pancreatic islet β-cell failure, which is manifested under cellular stress induced by metabolic overload. The decrease in the functional β-cell mass associated with T2D has been attr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b9300f8d1841e33c86cd6122912a26
https://pubmed.ncbi.nlm.nih.gov/31298804
https://pubmed.ncbi.nlm.nih.gov/31298804
Autor:
Shimon Efrat
Publikováno v:
Current Opinion in Endocrinology, Diabetes & Obesity. 20:259-264
PURPOSE OF REVIEW This review evaluates recent progress in several approaches aimed at developing human surrogate β cells, and identifies gaps that need to be filled for bringing them closer to clinical application. RECENT FINDINGS Cells expanded in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2075746d7158c7abd4149060caf8f66c
https://doi.org/10.1097/med.0b013e32836313d4
https://doi.org/10.1097/med.0b013e32836313d4