Zobrazeno 1 - 10
of 687
pro vyhledávání: '"Shimon, Sakaguchi"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/f25cf6daa29f49029a5537c3380f7395
Autor:
Kevin Baßler, Lisa Schmidleithner, Mehrnoush Hadaddzadeh Shakiba, Tarek Elmzzahi, Maren Köhne, Stefan Floess, Rebekka Scholz, Naganari Ohkura, Timothy Sadlon, Kathrin Klee, Anna Neubauer, Shimon Sakaguchi, Simon C. Barry, Jochen Huehn, Lorenzo Bonaguro, Thomas Ulas, Marc Beyer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
CD4+ T cells play a central role in the adaptive immune response through their capacity to activate, support and control other immune cells. Although these cells have become the focus of intense research, a comprehensive understanding of the underlyi
Externí odkaz:
https://doaj.org/article/08e3960cd2734ae4aaeb37de7e1fb8d2
Autor:
Masaaki Okamoto, Miwa Sasai, Ayumi Kuratani, Daisuke Okuzaki, Masaya Arai, James B. Wing, Shimon Sakaguchi, Masahiro Yamamoto
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112813- (2023)
Summary: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions. Here, to determine the roles of T-bet-expressing Treg cells, we generate a mouse strain
Externí odkaz:
https://doaj.org/article/039174eb253942a08c8589cb37a7924c
Autor:
Yoshiaki Yasumizu, Naganari Ohkura, Hisashi Murata, Makoto Kinoshita, Soichiro Funaki, Satoshi Nojima, Kansuke Kido, Masaharu Kohara, Daisuke Motooka, Daisuke Okuzaki, Shuji Suganami, Eriko Takeuchi, Yamami Nakamura, Yusuke Takeshima, Masaya Arai, Satoru Tada, Meinoshin Okumura, Eiichi Morii, Yasushi Shintani, Shimon Sakaguchi, Tatsusada Okuno, Hideki Mochizuki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Myasthenia Gravis and thymoma are frequently associated with patients suffering from both diseases. Here the authors perform single cell sequencing of thymoma and find that there are autoimmune antigens such as neuromuscular proteins expressed aberra
Externí odkaz:
https://doaj.org/article/2570824143ef4a838ef3341d99555822
Autor:
Noriko Goda, Shinsuke Sasada, Hideo Shigematsu, Norio Masumoto, Koji Arihiro, Hiroyoshi Nishikawa, Shimon Sakaguchi, Morihito Okada, Takayuki Kadoya
Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Purpose FOXP3 + and CD8 + are recognized markers of tumor-infiltrating lymphocytes (TILs) for breast cancer. FOXP3 + TILs are composed of effector Tregs (eTregs) and other subpopulations that are classified by their differences in suppressiv
Externí odkaz:
https://doaj.org/article/70b346668fcf43289c7b737ddf251d88
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101694- (2022)
Summary: The establishment of regulatory T cells (Treg)-specific demethylation regions (TSDRs) is essential for the Treg-lineage stability. Here, we present a protocol using bisulfite sequencing to assess Treg-lineage stability. The protocol describe
Externí odkaz:
https://doaj.org/article/56d8e6cfa2a8432eb2ad36787a6e8a54
Autor:
Yusuke Takeuchi, Daiya Ohara, Hitomi Watanabe, Noriko Sakaguchi, Shimon Sakaguchi, Gen Kondoh, Akio Morinobu, Tsuneyo Mimori, Keiji Hirota
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Programmed necrosis, such as necroptosis and pyroptosis, is a highly pro-inflammatory cellular event that is associated with chronic inflammation. Although there are various triggers of pyroptosis and necroptosis in autoimmune tissue inflamm
Externí odkaz:
https://doaj.org/article/cb03ee5c22bb4c15b64ef71023e4d277
Autor:
Norihisa Mikami, Hiroko Tani, Ryoji Kawakami, Atsushi Sugimoto, Shimon Sakaguchi, Tomoki Ikuta
Publikováno v:
Food Science & Nutrition, Vol 9, Iss 6, Pp 3200-3208 (2021)
Abstract FoxP3+ regulatory T cells (Tregs) are needed to suppress inflammatory diseases and maintain immune homeostasis. The suppressive function of Tregs can be used to control autoimmune or inflammatory diseases; therefore, it is well studied how T
Externí odkaz:
https://doaj.org/article/a627301572ac49ae87690b4ca531372e
Autor:
Yang Yang, Xiao Li, Zhihai Ma, Chunlin Wang, Qunying Yang, Miranda Byrne-Steele, Rongjian Hong, Qing Min, Gao Zhou, Yong Cheng, Guang Qin, Justin V. Youngyunpipatkul, James B. Wing, Shimon Sakaguchi, Christian Toonstra, Lai-Xi Wang, Jose G. Vilches-Moure, Denong Wang, Michael P. Snyder, Ji-Yang Wang, Jian Han, Leonore A. Herzenberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
CTLA-4 is an important co-inhibitory receptor for T cells. Here, the authors show that CTLA-4 also has a function on B-1a cells, as conditional deletion results in activation of these cells and knockout mice develop an autoimmune profile.
Externí odkaz:
https://doaj.org/article/229a32c1fd3d4c71969347ac1499f7d4
Publikováno v:
Cancer Cell. 41:450-465