Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shimizu SH"'
Autor:
Yan Zhao, Yuansong Bai, Mei Li, Xin Nie, Hao Meng, Shimizu Shosei, Linlin Liu, Qingbiao Yang, Meili Shen, Yapeng Li
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Triple negative breast cancer (TNBC) has the characteristics of low immune cell infiltration, high expression of tumor programmed death ligand 1 (PD-L1), and abundant cancer stem cells. Systemic toxicity of traditional chemotherapy drugs due
Externí odkaz:
https://doaj.org/article/af876d4d4a43432080e25cf13a6bb82f
Publikováno v:
Pteridines, Vol 19, Iss 1, Pp 93-100 (2008)
Tetrahydrobiopterin (BH4) content in the pancreas from GK (Goto-Kakizaki) rats as a type II diabetic model was markedly decreased compared to Wistar rats as a healthy control. Moreover, insulin stimulated BH4 synthesis in a hamster pancreatic β-cell
Externí odkaz:
https://doaj.org/article/149956e62dd84195a5c381769eb301a2
Publikováno v:
Pteridines, Vol 17, Iss 3, Pp 69-73 (2006)
We examined the role of endogenous tetrahydrobiopterin (BH4) on L-tyrosine-induced increase in cytosolic Ca: concentration ([Ca2+],) in the ß-cell line, HIT-T15. Addition of L-tyrosine to the cells increased [Ca2+], in a conccntration- depcndent man
Externí odkaz:
https://doaj.org/article/3c6580d0062b4631808b90537f2f8411
Publikováno v:
Pteridines, Vol 17, Iss 1, Pp 5-10 (2006)
5,6,7,8-Tetrahydrobiopterin (BH4) is an csscntial cofactor for production of nitric oxide (NO) by N O synthase (NOS). Nitric oxide (NO) is an important signaling mo!ecu!e for the regulation o f vita! functions such as vascular tone, neurotransmission
Externí odkaz:
https://doaj.org/article/4484949d2a6648c8831d446782045438
Autor:
Ishii Masakazu, Shimizu Shunichi, Hagiwara Tamio, Wajima Teruaki, Miyazaki Akira, Mori Yasuo, Kiuchi Yuji
Publikováno v:
Journal of Pharmacological Sciences, Vol 101, Iss 2, Pp 174-178 (2006)
Abstract.: Intracellular ADP-ribose is an activator of TRPM2, which is a Ca2+-permeable channel and mediates H2O2-induced cell death, in the TRPM2-expressing rat β-cell line RIN-5F. We examined the effect of extracellular-added ADP-ribose on intrace
Externí odkaz:
https://doaj.org/article/63f1d45e746747acbf15e7e5581a0bc5
Publikováno v:
Pteridines, Vol 14, Iss 1, Pp 9-12 (2003)
The purpose of this study was to examine whether basic fibroblast growth factor (bFGF) stimulates tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells. BH4 content was determined by oxidation under acidic conditions as b
Externí odkaz:
https://doaj.org/article/288fe73ba41840a1803d3a2a639a3f4f
Autor:
Ishii Masakazu, Shimizu Shunichi, Shiota Kazuhiro, Yamamoto Shinichiro, Kiuchi Yuji, Yamamoto Toshinori
Publikováno v:
Pteridines, Vol 13, Iss 3, Pp 89-93 (2002)
We examined the effect of immunosuppressant cyclosporin A (CsA) on the synthesis of tetrahydrobiopterin (BH4), which is a cofactor for nitric oxide synthase (NOS), during treatment with lipopolysaccharide (LPS) in mouse brain microvascular endothelia
Externí odkaz:
https://doaj.org/article/835a0e296b534b7d80e46ba4c18497d7
Autor:
Shiota Kazuhiro, Shimizu Shumchi, Ishii Masakazu, Yamamoto Shinichiro, Iwasaki Michiko, Yamamoto Toshinori, Kiuchi Yuji
Publikováno v:
Pteridines, Vol 13, Iss 1, Pp 21-25 (2002)
Tetrahydrobiopterin (BH4) is one of the cofactors for nitric oxide synthase (NOS), and also has a protective effect against reactive oxygen species (ROS)- and/or nitric oxide (NO)-induced cytotoxicities. Lipopolysaccharide (LPS) induces NO production
Externí odkaz:
https://doaj.org/article/34e11cd7651a4953ae0c037524b1b6c2
Autor:
Shimizu Shunichi
Publikováno v:
Pteridines, Vol 13, Iss 1, Pp 32-37 (2002)
Vascular endothelial cells are one of the major biological targets of reactive oxygen species (ROS) in ischemiareperfusion, diabetes, hypercholesterolemia and inflammation. Accumulated evidence has shown that tetrahydrobiopterin (BH4), which is an es
Externí odkaz:
https://doaj.org/article/bd84569e71094b1582266e8bdcab2e8c
Autor:
Ishii Masakazu, Shimizu Shunichi, Nagai Tsutomu, Kazuhiro Shiota, Kiuchi Yuji, Yamamoto Toshinori
Publikováno v:
Pteridines, Vol 12, Iss 4, Pp 161-166 (2001)
We examined the role ofprotein kinase C (PKC) in the insulin-induced biosynthesis oftetrahydrobiopterin (BH4)' which is one of the co factors of nitric oxide (NO) synthase (NOS), in vascular endothelial cells. The BH. level was determined as biopteri
Externí odkaz:
https://doaj.org/article/8514dbf98b604e1f9c47a21f0219eab9