Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Shimin Le"'
Autor:
Yuhang Zhang, Jingyi Du, Xian Liu, Fei Shang, Yunxin Deng, Jiaqing Ye, Yukai Wang, Jie Yan, Hu Chen, Miao Yu, Shimin Le
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract α-Actinins play crucial roles in cytoskeletal mechanobiology by acting as force-bearing structural modules that orchestrate and sustain the cytoskeletal framework, serving as pivotal hubs for diverse mechanosensing proteins. The mechanical
Externí odkaz:
https://doaj.org/article/c8a32eabd27f41f18dcd484f7f526eae
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Titin N2B unique sequence (N2B-us) is a 572 amino acid sequence that acts as an elastic spring to regulate muscle passive elasticity. It is thought to lack stable tertiary structures and is a force-bearing region that is regulated by mechani
Externí odkaz:
https://doaj.org/article/76be120cb7bd4727bbca2eb7ffe8917a
Publikováno v:
APL Bioengineering, Vol 8, Iss 1, Pp 016114-016114-11 (2024)
α-Synuclein aggregation is a common trait in synucleinopathies, including Parkinson's disease. Being an unstructured protein, α-synuclein exists in several distinct conformational intermediates, contributing to both its function and pathogenesis. H
Externí odkaz:
https://doaj.org/article/bf6630149bac433a8918b1693654d2db
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mechanically stable specific heterodimerization formed with reversible bonds are used as a molecular anchorage in single-molecule force spectroscopy studies with unique mechanical properties. Here authors develop a variety of heterodimerization molec
Externí odkaz:
https://doaj.org/article/6493dafac0c14df7a1b27ea21780a881
Autor:
Shimin Le, Xian Hu, Mingxi Yao, Hu Chen, Miao Yu, Xiaochun Xu, Naotaka Nakazawa, Felix M. Margadant, Michael P. Sheetz, Jie Yan
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2714-2723 (2017)
Summary: α-Actinins, a family of critical cytoskeletal actin-binding proteins that usually exist as anti-parallel dimers, play crucial roles in organizing the framework of the cytoskeleton through crosslinking the actin filaments, as well as in foca
Externí odkaz:
https://doaj.org/article/2bb50e12db49420da3892aa3fc69e6f2
Autor:
Miao Yu, Xin Yuan, Chen Lu, Shimin Le, Ryo Kawamura, Artem K. Efremov, Zhihai Zhao, Michael M. Kozlov, Michael Sheetz, Alexander Bershadsky, Jie Yan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Formins are actin-polymerisation factors that are sensitive to force. Here the authors find that pulling force on an actin filament promoted faster actin polymerisation by the formin mDia1, and also found that the actin filament must be torsionally u
Externí odkaz:
https://doaj.org/article/45b944b61fe7413f8f71e13ac4d739be
Autor:
Miao Yu, Shimin Le, Samuel Barnett, Zhenhuan Guo, Xueying Zhong, Pakorn Kanchanawong, Jie Yan
Publikováno v:
Physical Review X, Vol 10, Iss 2, p 021001 (2020)
Molecular optogenetic switch systems are extensively employed as a powerful tool to spatially and temporally modulate a variety of signal transduction processes in cells. However, the applications of such systems in mechanotransduction processes wher
Externí odkaz:
https://doaj.org/article/0029205f72ef4d36b3a87106946820d9
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66712 (2013)
The RecA filament formed on double-stranded (ds) DNA is proposed to be a functional state analogous to that generated during the process of DNA strand exchange. RecA polymerization and de-polymerization on dsDNA is governed by multiple physiological
Externí odkaz:
https://doaj.org/article/d00893c97356424684775d4d791bdbb7
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 9/10/2024, Vol. 121 Issue 37, p1-11, 23p
Publikováno v:
Soft Matter; 5/14/2024, Vol. 20 Issue 18, p3780-3786, 7p