Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shimeng Qiu"'
Publikováno v:
Photonics, Vol 9, Iss 7, p 483 (2022)
In this paper, the transmission mechanism of the spike information embedded in the low frequency fluctuation (LFF) dynamic in a cascaded laser system is numerically demonstrated. In the cascaded laser system, the LFF waveform is first generated by a
Externí odkaz:
https://doaj.org/article/a4fc1e256ad94d1cb476ef1a2c90439e
Autor:
Shimeng Qiu, Yaling Li, Yuki Imakura, Shinji Mima, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
Publikováno v:
Cells, Vol 10, Iss 4, p 812 (2021)
The endoderm, differentiated from human induced pluripotent stem cells (iPSCs), can differentiate into the small intestine and liver, which are vital for drug absorption and metabolism. The development of human iPSC-derived enterocytes (HiEnts) and h
Externí odkaz:
https://doaj.org/article/7a0daf8556dd4f628895b163e6229f6c
Autor:
Shimeng Qiu, Tomoki Kabeya, Isamu Ogawa, Shiho Anno, Hisato Hayashi, Tatsuro Kanaki, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 951 (2020)
The evaluation of drug pharmacokinetics in the small intestine is critical for developing orally administered drugs. Caucasian colon adenocarcinoma (Caco-2) cells are employed to evaluate drug absorption in preclinical trials of drug development. How
Externí odkaz:
https://doaj.org/article/6cc496b6a04f43cb9e6e94f363fe0ea1
Autor:
Takashi Kitaguchi, Shimeng Qiu, Taisei Mizota, Nobumitsu Hanioka, Kazuhiro Kobayashi, Ito Mina, Katsutoshi Ohno, Mitsuru Tanaka, Takahiro Iwao, Tamihide Matsunaga, Isamu Ogawa
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(1)
Pharmacokinetic prediction after oral ingestion is important for quantitative risk assessment of food-derived compounds. To evaluate the utility of human intestinal absorption prediction, we compared the membrane permeability and metabolic activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdfdd99de6e0b6eb099ced7768e8ade
https://pubmed.ncbi.nlm.nih.gov/34670778
https://pubmed.ncbi.nlm.nih.gov/34670778
Autor:
Tadahiro Hashita, Shimeng Qiu, Shiho Anno, Takahiro Iwao, Tamihide Matsunaga, Hisato Hayashi, Isamu Ogawa, Tatsuro Kanaki, Tomoki Kabeya
Publikováno v:
Pharmaceutics
Volume 12
Issue 10
Pharmaceutics, Vol 12, Iss 951, p 951 (2020)
Volume 12
Issue 10
Pharmaceutics, Vol 12, Iss 951, p 951 (2020)
The evaluation of drug pharmacokinetics in the small intestine is critical for developing orally administered drugs. Caucasian colon adenocarcinoma (Caco-2) cells are employed to evaluate drug absorption in preclinical trials of drug development. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ef433d9d07c7008b81be1ea50aa858
https://pubmed.ncbi.nlm.nih.gov/33050367
https://pubmed.ncbi.nlm.nih.gov/33050367
Autor:
Shimeng Qiu, Mizuka Nagasaki, Nao Kodama, Tamihide Matsunaga, Momona Hibino, Takahiro Iwao, Tomoki Kabeya
Publikováno v:
Drug Metabolism and Disposition. 46:1411-1419
To develop a novel in vitro system for predicting intestinal drug absorption using human induced pluripotent stem (iPS) cell-derived intestinal epithelial cells, the cells need to have sufficient drug-metabolizing enzyme and drug transporter activiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecdc9116d31d7fbe979d678dff2185a
https://doi.org/10.1124/dmd.118.082123
https://doi.org/10.1124/dmd.118.082123
Autor:
Yang Yang, Peng Liu, Fangyu Du, Wei Jiang, Gao Jinheng, Xing Tang, Tianyan Chi, Shimeng Qiu, Chengwen Chen, Xuefei Ji, Jia Xu, Qifan Zhou, Hongli Lang, Danyang Liu, Xiaoyu Zhou, Libo Zou, Guoliang Chen, Yuan Chunling, Xiaoli Guo
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1865(1)
The pathogenesis of Alzheimer's disease (AD) is complex, though the clinical failures of anti-AD candidates targeting Aβ production (such as β- and γ-secretase inhibitors) make people suspect the Aβ hypothesis, in which the neurotoxicity of Aβ i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2681cac45933c1e778212f67ff3717f3
https://pubmed.ncbi.nlm.nih.gov/30389579
https://pubmed.ncbi.nlm.nih.gov/30389579
Autor:
Shijie Song, Da-Li Meng, Peng Liu, Xuefei Ji, Lili Wang, Ge Jin, Tianyan Chi, Shimeng Qiu, Libo Zou, Pu Xu, Yinjie Li, Jikai Xu, Yapeng Hou, Chen Zheng
Publikováno v:
Neuroscience letters. 629
Xanthoceras sorbifolia, a traditional Chinese folk medicine with anti-inflammatory effects, has been used for a long time in China, especially in the Inner Mongolian area for the treatment of rheumatism. Inflammation is one of the main causes of Alzh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdcb0999455731843807d550154a218
https://pubmed.ncbi.nlm.nih.gov/27412235
https://pubmed.ncbi.nlm.nih.gov/27412235