Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Shima Nakanishi"'
Autor:
Shima Nakanishi, John L. Cleveland
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8171 (2024)
The unique amino acid hypusine [Nε-(4-amino-2-hydroxybutyl)lysine] is exclusively formed on the translational regulator eukaryotic initiation factor 5A (eIF5A) via a process coined hypusination. Hypusination is mediated by two enzymes, deoxyhypusine
Externí odkaz:
https://doaj.org/article/4a7495598e44402996da91b819373da2
Autor:
Toshikazu Kitagawa, Shima Nakanishi, Aya Mizuno, Yohei Niwa, Hiroaki Tabata, Katsuyuki Hirai, Takao Okazaki
Publikováno v:
ARKIVOC, Vol 2018, Iss 2, Pp 131-144 (2017)
Externí odkaz:
https://doaj.org/article/b09fa44cf38e4352b82cb622c7b736a3
Autor:
Shima Nakanishi, John L. Cleveland
Publikováno v:
Medical Sciences, Vol 9, Iss 2, p 28 (2021)
Polycationic polyamines are present in nearly all living organisms and are essential for mammalian cell growth and survival, and for development. These positively charged molecules are involved in a variety of essential biological processes, yet thei
Externí odkaz:
https://doaj.org/article/0e48d9cf9270498591a34b3f69b0cfba
Autor:
Shima Nakanishi, Jiannong Li, Anders E. Berglund, Youngchul Kim, Yonghong Zhang, Ling Zhang, Chunying Yang, Jinming Song, Raghavendra G. Mirmira, John L. Cleveland
Publikováno v:
Blood Cancer Discovery.
The MYC oncoprotein is activated in a broad spectrum of human malignancies and transcriptionally reprograms the genome to drive cancer cell growth. Given this, it is unclear if targeting a single effector of MYC will have therapeutic benefit. MYC act
Autor:
John L. Cleveland, Shima Nakanishi
Publikováno v:
Medical Sciences, Vol 9, Iss 28, p 28 (2021)
Medical Sciences
Medical Sciences
Polycationic polyamines are present in nearly all living organisms and are essential for mammalian cell growth and survival, and for development. These positively charged molecules are involved in a variety of essential biological processes, yet thei
Autor:
John L. Cleveland, Shima Nakanishi
Publikováno v:
Amino Acids. 48:2353-2362
The unique amino acid hypusine is present in only two proteins in eukaryotic cells, eukaryotic translation initiation factor 5A-1 (eIF5A1), and eIF5A2, where it is covalently linked to the lysine-50 residue of these proteins via a post-translational
Autor:
Ronald J. Rahaim, Yoshihiko Noguchi, Yangbo Feng, Shima Nakanishi, Lin Li, Konstantin Licht, Laura H. Rosenberg, Weimin Chen, John L. Cleveland, Stephan C. Schürer, William R. Roush, Jun Yong Choi, Michael D. Cameron, Mathieu Bibian, Derek R. Duckett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4374-4380
The development of a series of potent and highly selective casein kinase 1δ/e (CK1δ/e) inhibitors is described. Starting from a purine scaffold inhibitor (SR-653234) identified by high throughput screening, we developed a series of potent and highl
Autor:
Arvind Gupta, Julia M. Schulze, Ali Shilatifard, Thomas Hentrich, Shima Nakanishi, Michael S. Kobor, Eldon Emberly
Publikováno v:
Genes & Development. 25:2242-2247
Monoubiquitination of H2BK123 (H2BK123ub), catalyzed by Rad6/Bre1, is a transient histone modification with roles in transcription and is essential for establishing H3K4 and H3K79 trimethylations (H3K4me3 and H3K79me3). Here, we investigated the chro
Autor:
Kym M. Delventhal, Brian W. Sanderson, Ali Shilatifard, Karen Staehling-Hampton, William D. Bradford, Shima Nakanishi
Publikováno v:
Nature structural & molecular biology
Methylation of histone 3 lysine 4 (H3K4) by yeast Set1-COMPASS requires prior monoubiquitination of histone H2B. To define whether other residues within the histones are also required for H3K4 methylation, we systematically generated a complete libra
Publikováno v:
Nucleic Acids Research
Chromatin in eukaryotic cells is folded into higher order structures of folded nucleosome filaments, and DNA damage occurs at all levels of this structural hierarchy. However, little is known about the impact of higher order folding on DNA repair enz