Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Shima Kumei"'
Autor:
Shima Kumei, Masatomo Ishioh, Yuki Murakami, Katsuyoshi Ando, Tsukasa Nozu, Toshikatsu Okumura
Publikováno v:
Journal of Medical Case Reports, Vol 16, Iss 1, Pp 1-5 (2022)
Abstract Background Irritable bowel syndrome is a functional gastrointestinal disease. Visceral hypersensitivity is the most important pathophysiology in irritable bowel syndrome. Currently, diagnosis of irritable bowel syndrome is based on symptoms
Externí odkaz:
https://doaj.org/article/a51199dbd44e4690a87a52a5a494e9fe
Publikováno v:
Journal of Pharmacological Sciences, Vol 146, Iss 4, Pp 183-191 (2021)
Short chain fatty acids readily crosses the gut-blood and blood–brain barrier and acts centrally to influence neuronal signaling. We hypothesized that butyrate, a short-chain fatty acid produced by bacterial fermentation, in the central nervous sys
Externí odkaz:
https://doaj.org/article/8eed3ad7b3d34f80afab3a1f2f39f763
Publikováno v:
Journal of Pharmacological Sciences, Vol 137, Iss 2, Pp 230-232 (2018)
We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of
Externí odkaz:
https://doaj.org/article/1e7ea592b87b41cc90e233a1d9d2e9fd
Autor:
Toshikatsu Okumura, Tsukasa Nozu, Shima Kumei, Kaoru Takakusaki, Saori Miyagishi, Masumi Ohhira
Publikováno v:
Journal of Pharmacological Sciences, Vol 130, Iss 2, Pp 123-127 (2016)
Levodopa possesses antinociceptive actions against several somatic pain conditions. However, we do not know at this moment whether levodopa is also effective to visceral pain. The present study was therefore performed to clarify whether levodopa is e
Externí odkaz:
https://doaj.org/article/3263716bf5c245c8aa9749ff82068f72
Autor:
Hitoshi Kashiwagi, Koh-ichi Yuhki, Yoshitaka Imamichi, Fumiaki Kojima, Shima Kumei, Tsunehito Higashi, Takahiro Horinouchi, Soichi Miwa, Shuh Narumiya, Fumitaka Ushikubi
Publikováno v:
TH Open, Vol 01, Iss 02, Pp e122-e129 (2017)
The results of studies that were performed to determine whether cigarette smoking affects platelet function have been controversial, and the effects of nicotine- and tar-free cigarette smoke extract (CSE) on platelet function remain to be determined.
Externí odkaz:
https://doaj.org/article/fba1e4b6dccf43528bc4de002045df76
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119147 (2015)
The Patient Health Questionnaire (PHQ-9) is a self-report questionnaire commonly used to screen for depression, with ≥8-11 generally recommended as the cut-off. In Japan, studies of the validity of the PHQ-9 and PHQ-2 have been limited. In this stu
Externí odkaz:
https://doaj.org/article/34df3d70eab74034a22dd340d469070a
Background and Purpose We attempted to clarify a role of prostaglandin (PG) I2 and its specific receptor, IP in the pathogenesis of irritable bowel syndrome (IBS). Experimetal Approach Using a maternal separation (MS)-induced rat IBS model, the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457321627414bcb897fe2f895467e46f
https://doi.org/10.22541/au.166206422.29548188/v1
https://doi.org/10.22541/au.166206422.29548188/v1
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 393:1419-1425
We have recently demonstrated that levodopa acts centrally to induce antinociceptive action against colonic distension through dopamine D2 receptors in rats. Since serotonin (5-HT) and cannabinoid are involved in the regulation of visceral sensation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b41d299b5c8aece87c14d57db162e05
https://doi.org/10.1007/s00210-020-01842-0
https://doi.org/10.1007/s00210-020-01842-0
Autor:
Toshikatsu Okumura, Tsukasa Nozu, Masatomo Ishioh, Sho Igarashi, Takuya Funayama, Shima Kumei, Masumi Ohhira
Publikováno v:
SSRN Electronic Journal.
Brain oxytocin plays a role in gastrointestinal functions. Among them, oxytocin acts centrally to modulate gastrointestinal motility and visceral sensation. Intestinal barrier function, one of important gut functions, is also regulated by the central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fd5fdc21bf9e86ca26adf57a2a433d
https://doi.org/10.2139/ssrn.4090943
https://doi.org/10.2139/ssrn.4090943
Publikováno v:
Internal Medicine; 2022, Vol. 61 Issue 16, p2427-2430, 4p