A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours.

Autor: Nohara LL; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Ellis SLS; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Dreier C; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Dada S; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Departments of Medical Genetics, Zoology, and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada., Saranchova I; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Departments of Medical Genetics, Zoology, and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada., Bok Choi K; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada., Munro L; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Al Haddad E; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada., Pfeifer CG; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., Coyle KM; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Morrice JR; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada., Shim DJS; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada., Ahn P; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada., De Voogd N; Netherlands Centre for Biodiversity Naturalis, Leiden, Netherlands., Williams DE; Departments of Chemistry and Earth Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada., Cheng P; Departments of Chemistry and Earth Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada., Garrovillas E; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada., Andersen RJ; Departments of Chemistry and Earth Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC, Canada., Jefferies WA; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.; Departments of Medical Genetics, Zoology, and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2023 May 15; Vol. 14, pp. 1119607. Date of Electronic Publication: 2023 May 15 (Print Publication: 2023).