Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche

Autor: Shilu Amin, Roel Neijts, Salvatore Simmini, Carina van Rooijen, Sander C. Tan, Lennart Kester, Alexander van Oudenaarden, Menno P. Creyghton, Jacqueline Deschamps

Publikováno v: Cell Reports, Vol 17, Iss 12, Pp 3165-3177 (2016)

In vertebrate embryos, anterior tissues are generated early, followed by the other axial structures that emerge sequentially from a posterior growth zone. The genetic network driving posterior axial elongation in mice, and its disturbance in mutants

Externí odkaz: https://doaj.org/article/4ab8ee6139bb4f9fa7f97daeb5e5aefe

Uncovering tissue-specific binding features from differential deep learning

Autor: Laure Bridoux, Peyman Zarrineh, Nicoletta Bobola, Shilu Amin, Mike Phuycharoen, Marta Losa, Ke Chen, Magnus Rattray

Publikováno v: Nucleic Acids Research
Phuycharoen, M, Zarrineh, P, Bridoux, L, Amin, S, Losa, M, Chen, K, Bobola, N & Rattray, M 2020, ' Uncovering tissue-specific binding features from differential deep learning ', Nucleic Acids Res . https://doi.org/10.1093/nar/gkaa009

MotivationTranscription factors (TFs) can bind DNA in a cooperative manner, enabling a mutual increase in occupancy. Through this type of interaction, alternative binding sites can be preferentially bound in different tissues to regulate tissue-speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdb063b8ac98e6900240fca90b545bf
https://pubmed.ncbi.nlm.nih.gov/31974574

Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology

Autor: Jacqueline Deschamps, Carina van Rooijen, Shilu Amin, Roel Neijts

Publikováno v: Developmental Biology. Academic Press
Developmental Biology, 422(2), 146. Academic Press Inc.

Cdx and Hox transcription factors are important regulators of axial patterning and are required for tissue generation along the vertebrate body axis. Cdx genes have been demonstrated to act upstream of Hox genes in midgestation embryos. Here, we inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0900c092e7521f1544294dec6374a4c1
https://pure.knaw.nl/portal/en/publications/b58c0c7f-9853-4781-b442-37c037e807c3

Histone Methyltransferase ASH1 Orchestrates Fibrogenic Gene Transcription During Myofibroblast Transdifferentiation

Autor: Maria J. Perugorria, Alastair D. Burt, Meagan Walsh, Fiona Oakley, Steven A. White, Shilu Amin, Hidekazu Tsukamoto, Müjdat Zeybel, Caroline L. Wilson, Stuart Robinson, Jelena Mann, Derek A. Mann

Publikováno v: Hepatology (Baltimore, Md.)

Transdifferentiation of hepatic stellate cells (HSCs) to a myofibroblast-like phenotype is the pivotal event in liver fibrosis. The dramatic change in phenotype associated with transdifferentiation is underpinned by a global change in gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfe10cb34ebc92794ac5d40b03f3c9e
http://europepmc.org/articles/PMC3430805

Genome-wide occupancy links Hoxa2 to Wnt–β-catenin signaling in mouse embryonic development

Autor: James Hensman, Andrew Hayes, Ian J. Donaldson, Eva Kutejova, Shilu Amin, Magnus Rattray, Christopher M. Ward, Nicoletta Bobola, Neil D. Lawrence

Publikováno v: Nucleic Acids Research

The regulation of gene expression is central to developmental programs and largely depends on the binding of sequence-specific transcription factors with cis-regulatory elements in the genome. Hox transcription factors specify the spatial coordinates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe708b863aa23fb0aaa30c9dd2a1e1eb
https://doi.org/10.1093/nar/gkr1240