Výsledky vyhledávání - "Shilpkala Gade"

Akademický článek

Development and characterization of injectable depot forming thermoresponsive hydrogel for the sustained intrascleral delivery of Sunitinib

Autor: Shilpkala Gade, Eneko Larrañeta, Ryan F Donnelly, Rocio Herrero Vanrell, Carmen Isabel Alvarez Lorenzo, Raghu Raj Singh Thakur

Publikováno v: British Journal of Pharmacy, Vol 7, Iss 2 (2022)

Age-related macular degeneration (AMD) is a potentially blinding posterior segment disease; inflammatory responses and subretinal drusen formation lead to leaky blood vessels. The current treatment method involves intravitreal injections of anti-VEGF

Externí odkaz: https://doaj.org/article/116e1fbeefa547489927d2812ca12931

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Development of injectable thermoresponsive Cs‐g‐PNIPAAm hydrogel for intrascleral drug delivery of sunitinib malate for the posterior segment ocular disease, age‐related macular degeneration

Autor: Shilpkala Gade, Eneko Larraneta, Ryan F. Donnelly, Rocio Herrero Vanrell, Carmen Alvarez‐Lorenzo, Raghu Raj Singh Thakur

Publikováno v: Acta Ophthalmologica. 100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fa8afdfb0379b010299199ce08304ca
https://doi.org/10.1111/j.1755-3768.2022.15542

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Vitreous humor: composition, characteristics and implication on intravitreal drug delivery

Autor: Deepakkumar Mishra, Shilpkala Gade, Katie Glover, Ravi Sheshala, Thakur Raghu Raj Singh

Publikováno v: Mishra, D, Gade, S, Glover, K, Sheshala, R & Singh, T R R 2022, ' Vitreous humor: composition, characteristics and implication on intravitreal drug delivery ', Current eye research . https://doi.org/10.1080/02713683.2022.2119254

Purpose: Intravitreal administration of drug molecules is one of the most common routes for treating posterior segment eye diseases. However, the properties of vitreous humour changes with the time. A number of ocular complications such as liquefacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32501097070cebc049c39ba59b2f3286
https://pure.qub.ac.uk/en/publications/b6833719-82a1-41ba-8c53-9433df412a34

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Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye

Autor: Yu Wu, Lalitkumar K. Vora, Deepakkumar Mishra, Muhammad Faris Adrianto, Shilpkala Gade, Alejandro J. Paredes, Ryan F. Donnelly, Thakur Raghu Raj Singh

Publikováno v: Biomaterials advances. 137

Intravitreal injections (IVT) are regarded as the gold standard for effective delivery of hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the injection itself may lead to poor patient compliance and severe complicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80320d9a86e9f2952614192e768affca
https://pubmed.ncbi.nlm.nih.gov/35929230

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Effect of penetration enhancers and amorphization on transdermal permeation flux of raloxifene-encapsulated solid lipid nanoparticles: an ex vivo study on human skin

Autor: Md. Meraj Anjum, Shilpkala Gade, Krishna Kumar Patel, Sanjay Singh, Ashish Kumar Agrawal, Pralay Maiti

Publikováno v: Applied Nanoscience. 9:1383-1394

Despite 60% oral absorption, high first-pass metabolisms resulted in 2% oral bioavailability of raloxifene and also suffer poor water solubility. In this study, we developed the penetration enhancer rich hydrogel containing raloxifene-loaded solid li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46704e7bf3f9c38bbe25a425ef4312df
https://doi.org/10.1007/s13204-019-01004-6

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Alginate lyase immobilized chitosan nanoparticles of ciprofloxacin for the improved antimicrobial activity against the biofilm associated mucoid P. aeruginosa infection in cystic fibrosis

Autor: Sanjay Singh, Ragini Tilak, Nidhi Pandey, Ashish Kumar Agrawal, Krishna Kumar Patel, Md. Meraj Anjum, Shilpkala Gade, Muktanand Tripathi

Publikováno v: International journal of pharmaceutics. 563

Dense colonization of mucoid Pseudomonas aeruginosa within the self-secreted extracellular matrix (mainly alginate), called biofilm, is a principal reason for the failure of antimicrobial therapy in cystic fibrotic patients. Alginate is a key compone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9080a8201ca9230fd90aa56356e004a1
https://pubmed.ncbi.nlm.nih.gov/30926526

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An Ex Vivo Evaluation of Moxifloxacin Nanostructured Lipid Carrier Enriched In Situ Gel for Transcorneal Permeation on Goat Cornea

Autor: Krishna Kumar Patel, Sanjay Singh, Ashish Kumar Agrawal, Md. Meraj Anjum, Deepika Deepika, Shilpkala Gade, Chandan Kumar Gupta

Publikováno v: Journal of pharmaceutical sciences. 108(9)

The study was designed to fabricate the moxifloxacin nanostructured lipid carriers (MOX-NLCs) loaded in situ gel for opthalmic application to improve the corneal permeation and retention and also subside the toxic effect associated with intracameral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a0d8298695b9651bc2343e86ffc0e0
https://pubmed.ncbi.nlm.nih.gov/30978345

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