Abstract 2384: Preclinical evaluation of PD and efficacy of novel potent selective and orally bioavailable CDK12 covalent inhibitors in TNBC model

Autor: Shekar Chelur, Srinivas Kondela, Samiulla D S, Sivapriya Marappan, Murali Ramachandra, Girish Daginakatte, Ravindra M, Amit A. Dhudashiya, Charamanna K. B, Chetan Pandit, Ramulu Poddutoori, Devaraja T. S, Subhendu Mukherjee, Hadianawala Murtuza, Suraj Tgore, Shilpa S. Nayak, Sujatha Rajagopalan, Sasirekha Sivakumar, Thomas Antony, Susanta Samajdar, Sanjeev Giri

Publikováno v: Cancer Research. 78:2384-2384

Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase that participates in various cellular processes such as DNA damage response, splicing and pre-mRNA processing. In association with Cyclin K (CycK), CDK12 regulates transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f1c98487ef5b7c8efe5deed35de5d2f
https://doi.org/10.1158/1538-7445.am2018-2384

Abstract LB-317: Identification of a novel preclinical candidate for CDK7 inhibition

Autor: Leena Khare Satyam, Ravindra M, Dabbeeru Madhu Babu, Nandish C, Subhendu Mukherjee, Lakshmi Narayana Kaza, Shekar Chelur, Ramulu Poddutoori, Thomas Antony, Amith A, Sivapriya Marappan, Sreevalsam Gopinath, Manoj Pothuganti, Suraj Tgore, Shilpa S. Nayak, Chetan Pandit, Susanta Samajdar, Murali Ramachandra, Girish Daginakatte, Aravind Basavaraju, Nagaraju A

Publikováno v: Cancer Research. 77:LB-317

Cyclin-dependent kinase 7 (CDK7) is an important constituent of the cellular transcriptional machinery, where it phosphorylates the C-terminal domain (CTD) of RNAP polymerase II (RNAPII). Because many tumor types are critically dependent on transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c46468d204785e585c38528d1a33bb2c
https://doi.org/10.1158/1538-7445.am2017-lb-317

Abstract C190: Potent and selective inhibition of CDK7 by novel covalent inhibitors

Autor: Leena Khare Satyam, Nandish C, Shekar Chelur, Ramulu Poddutoori, Manoj Pothuganti, Girish Daginakatte, Madhu B. Dabbeeru, Anirudha Lakshminarasimhan, Ravindra M, Chetan Pandit, Subhendu Mukherjee, Sivapriya Marappan, Murali Ramachandra, Chandranath D. Naik, Shilpa S. Nayak, Susanta Samajdar, Raghuveer Ramachandra, Thomas Antony, Sreevalsam Gopinath

Publikováno v: Molecular Cancer Therapeutics. 14:C190-C190

Cyclin-dependent kinase 7 (CDK7) is an important constituent of the cellular transcriptional machinery, where it phosphorylates the C-terminal domain (CTD) of RNAP polymerase II (RNAPII). Because many tumor types are critically dependent on transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28fee644b5e3e11ba047ed4f15eb65da
https://doi.org/10.1158/1535-7163.targ-15-c190

The health impacts of women's low control in their living environment: A theory-based systematic review of observational studies in societies with profound gender discrimination.

Autor: Pennington A; Department of Public Health and Policy, Institute of Psychology, Health and Society, University of Liverpool, Whelan Building, Liverpool L69 3GB, United Kingdom. Electronic address: ajpenn@liverpool.ac.uk., Orton L; Department of Public Health and Policy, Institute of Psychology, Health and Society, University of Liverpool, Whelan Building, Liverpool L69 3GB, United Kingdom. Electronic address: lorton@liverpool.ac.uk., Nayak S; Department of Public Health and Policy, Institute of Psychology, Health and Society, University of Liverpool, Whelan Building, Liverpool L69 3GB, United Kingdom. Electronic address: shilpan@liverpool.ac.uk., Ring A; Department of Public Health and Policy, Institute of Psychology, Health and Society, University of Liverpool, Whelan Building, Liverpool L69 3GB, United Kingdom. Electronic address: adeler@liverpool.ac.uk., Petticrew M; Department of Social&Environmental Health Research, Faculty of Public Health&Policy, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, United Kingdom. Electronic address: Mark.Petticrew@lshtm.ac.uk., Sowden A; Centre for Reviews and Dissemination, University of York, Heslington, York YO10 5DD, United Kingdom. Electronic address: amanda.sowden@york.ac.uk., White M; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, United Kingdom. Electronic address: Martin.White@mrc-epid.cam.ac.uk., Whitehead M; Department of Public Health and Policy, Institute of Psychology, Health and Society, University of Liverpool, Whelan Building, Liverpool L69 3GB, United Kingdom. Electronic address: mmw@liverpool.ac.uk.

Publikováno v: Health & place [Health Place] 2018 May; Vol. 51, pp. 1-10. Date of Electronic Publication: 2018 Feb 23.

Group-based microfinance for collective empowerment: a systematic review of health impacts.

Autor: Orton L; Department of Public Health & Policy, University of Liverpool, Whelan Building, Quadrangle, Brownlow Hill, Liverpool, L69 3GB, England ., Pennington A; Department of Public Health & Policy, University of Liverpool, Whelan Building, Quadrangle, Brownlow Hill, Liverpool, L69 3GB, England ., Nayak S; Department of Public Health & Policy, University of Liverpool, Whelan Building, Quadrangle, Brownlow Hill, Liverpool, L69 3GB, England ., Sowden A; Centre for Reviews and Dissemination, University of York, York, England ., White M; UKCRC Centre for Diet and Activity Research, University of Cambridge, Cambridge, England ., Whitehead M; Department of Public Health & Policy, University of Liverpool, Whelan Building, Quadrangle, Brownlow Hill, Liverpool, L69 3GB, England .

Publikováno v: Bulletin of the World Health Organization [Bull World Health Organ] 2016 Sep 01; Vol. 94 (9), pp. 694-704A. Date of Electronic Publication: 2016 Jun 21.