Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus.

Autor: Hongshuo Song, Bhavna Hora, Tanmoy Bhattacharya, Nilu Goonetilleke, Michael K P Liu, Kevin Wiehe, Hui Li, Shilpa S Iyer, Andrew J McMichael, Alan S Perelson, Feng Gao

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102734 (2014)

Immune escape mutations that revert back to the consensus sequence frequently occur in newly HIV-1-infected individuals and have been thought to render the viruses more fit. However, their impact on viral fitness and their interaction with other immu

Externí odkaz: https://doaj.org/article/c29a8a2f8ba94141b1400ac1d51a81bc

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape.

Autor: Katharine J Bar, Chun-yen Tsao, Shilpa S Iyer, Julie M Decker, Yongping Yang, Mattia Bonsignori, Xi Chen, Kwan-Ki Hwang, David C Montefiori, Hua-Xin Liao, Peter Hraber, William Fischer, Hui Li, Shuyi Wang, Sarah Sterrett, Brandon F Keele, Vitaly V Ganusov, Alan S Perelson, Bette T Korber, Ivelin Georgiev, Jason S McLellan, Jeffrey W Pavlicek, Feng Gao, Barton F Haynes, Beatrice H Hahn, Peter D Kwong, George M Shaw

Publikováno v: PLoS Pathogens, Vol 8, Iss 5, p e1002721 (2012)

Single genome sequencing of early HIV-1 genomes provides a sensitive, dynamic assessment of virus evolution and insight into the earliest anti-viral immune responses in vivo. By using this approach, together with deep sequencing, site-directed mutage

Externí odkaz: https://doaj.org/article/3b0dc36fc26244f580f06b3696c32358

Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness

Autor: Ronnie M. Russell, Shilpa S. Iyer, Timothy Decker, Persephone Borrow, Gerald H. Learn, Marcos V. P. Gondim, Lindsey J. Plenderleith, Hannah J. Barbian, Yingying Li, Paul M. Sharp, Scott Sherrill-Mix, Beatrice H. Hahn, Christiana M. Shaw, Frederic Bibollet-Ruche, Barton F. Haynes, George M. Shaw, Catherine Y. Bahari, Andrew G. Smith

Publikováno v: Iyer, S S, Bibollet-Ruche, F, Sherrill-Mix, S, Learn, G H, Plenderleith, L J, Smith, A G, Barbian, H J, Russell, R M, Gondim, M V, Bahari, C Y, Shaw, C M, Li, Y, Decker, T, Haynes, B F, Shaw, G M, Sharp, P M, Borrow, P & Hahn, B H 2017, ' Resistance to Type 1 Interferons is a Major Determinant of HIV-1 Transmission Fitness ', Proceedings of the National Academy of Sciences, vol. 114, no. 4, pp. 590-599 . https://doi.org/10.1073/pnas.1620144114

Sexual transmission of HIV-1 is an inefficient process, with only one or few variants of the donor quasispecies establishing the new infection. A critical, and as yet unresolved, question is whether the mucosal bottleneck selects for viruses with inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa73725223d265b9f64d45f02ec43a5a
https://doi.org/10.1073/pnas.1620144114

Transmitted/Founder and Chronic HIV-1 Envelope Proteins Are Distinguished by Differential Utilization of CCR5

Autor: Benhur Lee, Craig B. Wilen, Fang-Hua Lee, Zahra F. Parker, Chukwuka A. Didigu, Shilpa S. Iyer, John P. Moore, Per Johan Klasse, Beatrice H. Hahn, Robert W. Doms, Kelechi Chikere, Reem Berro, George M. Shaw, Nicholas F. Parrish

Publikováno v: Journal of Virology. 87:2401-2411

Infection by HIV-1 most often results from the successful transmission and propagation of a single virus variant, termed the transmitted/founder (T/F) virus. Here, we compared the attachment and entry properties of envelope (Env) glycoproteins from T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f506c850cca66fc3bee8d211df8d7e20
https://doi.org/10.1128/jvi.02964-12

A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1

Autor: Beatrice H. Hahn, Daniel Sauter, Edward F. Kreider, Lan-Hui Lee, Gerald H. Learn, Simon Langer, Kristina Hopfensperger, Shilpa S. Iyer

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 11, p e0142118 (2015)

Background Pandemic strains of HIV-1 (group M) encode a total of nine structural (gag, pol, env), regulatory (rev, tat) and accessory (vif, vpr, vpu, nef) genes. However, some subtype A and C viruses exhibit an unusual gene arrangement in which the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18824d250f25d30793557c0a919e4dc5
https://pubmed.ncbi.nlm.nih.gov/26554585